Exercise-induced Legacy Health Benefits on Cardiometabolic Risk Factors in Aging Adults with Prediabetes

运动对患有前驱糖尿病的老年人的心脏代谢危险因素的传统健康益处

基本信息

批准号：
10353779
负责人：
WILLIAM E KRAUS
金额：
$ 20.13万
依托单位：
DUKE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-02-01 至 2023-11-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10353779
关键词：
Address Adopted Adult Advisory Committees Aerobic Aerobic Exercise Age Aging American Amino Acids Attenuated Automobile Driving Back Blood specimen Body Weight decreased Cardiometabolic Disease Cardiopulmonary Chronic Disease Clinical Data Diet Dyslipidemias Elderly Elements Exercise Exercise Test Fasting Fatty Acids Follow-Up Studies Foundations Glycine Goals Guidelines Health Health Benefit Individual Insulin Intervention Investigation Knowledge Lead Life Expectancy Life Style Light Lipids Lipoproteins Longevity Maintenance Mediating Medicine Metabolic Molecular Older Population Outcome Overweight Participant Pathway interactions Physical activity Physiological Plasma Prediabetes syndrome Proline Protocols documentation Public Health Reporting Research Risk Risk Factors Risk Reduction Supervision Time Training Programs acquired factor acylcarnitine age group age related aged arm blood lipid burden of illness cardiometabolic risk cardiometabolism cardiorespiratory fitness design diabetes prevention program diet and exercise disability exercise intensity exercise intervention exercise training fatty acid oxidation fitness follow-up metabolomics middle age novel peripheral blood randomized trial resilience sedentary vigorous intensity

项目摘要

Abstract Exercise training produces substantial health benefits, summarized in the Physical Activity Guidelines Advisory Committee Report and incorporated into the 2008 and 2018 Physical Activity Guidelines for Americans. Despite the well-known benefits, too few individuals adopt exercise as a health maintenance strategy. Thus, determining whether a relatively modest duration of exercise training in middle age can lead to sustained health benefits as individuals progress into older age groups (legacy effects) is of public health and clinical importance. In previously sedentary, overweight middle-aged adults with dyslipidemia, our STRRIDE I Reunion study revealed legacy effects for fitness and cardiometabolic risk factors 10 years following exercise intervention; some of these effects were specific to the amount and intensity of exercise performed. In light of the legacy benefits observed in STRRIDE I, the proposed STRRIDE-PD Reunion study seeks to determine the extent to which changes in fitness and cardiometabolic risk factors acquired in individuals aged 45-75 are maintained over a 10-year period in participants from the STRRIDE-Prediabetes (STRRIDE-PD) randomized trial. Importantly, the STRRIDE-PD Reunion will allow us to verify the observed legacy effects of aerobic exercise training in participants at greater risk for cardiometabolic disease. The STRRIDE-PD trial included a group similar to the lifestyle arm of the Diabetes Prevention Program, designed to achieve weight loss through diet and exercise. This unique design element will allow us to compare the ability of different aerobic exercise interventions – with and without weight loss – to elicit sustained cardiometabolic health benefits in adults with prediabetes. Combined with the previous STRRIDE studies, the STRRIDE-PD Reunion will solidify the scientific knowledge exploring the underlying molecular mechanisms by which exercise – differing in amount, intensity, and mode – produces sustained health benefits across the lifespan from age 45 to 85. Overall, findings from this research will demonstrate the power and value of exercise training programs of even modest duration to elicit long-term cardiometabolic health benefits.

抽象的锻炼训练会产生可观的健康益处，总结在《体育活动指南》咨询中委员会报告并纳入了2008年和2018年的美国人体育锻炼指南。尽管有众所周知的好处，但很少有人采用运动作为健康维护策略。那，确定中年相对适度的运动训练持续时间是否会导致持续随着个人成长年龄段（遗产效应），健康益处是公共卫生和临床重要性。在先前久坐的超重中年成年人中，我们的Strride I 团圆研究揭示了运动后10年对健身和心脏代谢风险因素的遗产影响干涉;其中一些影响特定于进行运动的数量和强度。鉴于拟议的strride-PD团聚研究旨在确定在45-75岁的个人中获得的适应性和心脏代谢危险因素的变化的程度是从strride-preDiabetes（strride-pd）随机的参与者中维持了10年的时间审判。重要的是，Strride-PD团聚将使我们能够验证有氧遗传的遗产效应对心脏代谢疾病风险更大的参与者进行运动训练。 Strride-PD试验包括类似于糖尿病预防计划的生活方式类似的组，旨在通过饮食和运动。这种独特的设计元素将使我们能够比较不同的有氧运动的能力干预措施 - 有或没有减肥 - 以在成年人中引起持续的心脏代谢健康益处糖尿病。结合先前的Strride研究，Strride-PD团聚将巩固科学知识探讨了锻炼的潜在分子机制 - 数量不同，强度和模式 - 从45岁到85岁的整个生命周期中产生持续的健康益处。总体而言，这项研究的结果将证明偶数锻炼计划的力量和价值持续时间引起长期心脏代谢健康益处。