Multi-excitation magnetoacoustic imaging of tissue conductivities

组织电导率的多激励磁声成像

• 批准号: 8549244
• 负责人: BIN HE
• 金额: $ 17.92万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-30 至 2016-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8549244
• 关键词: 3-Dimensional; Acoustics; Algorithms; Benign; Biomedical Research; Biopsy; Breast; Breast Cancer Detection; Breast Cancer Early Detection; Cancerous; Cessation of life; Clinical; Clinical Research; Computer Simulation; Development; Diagnosis; Early Diagnosis; Early treatment; Electric Conductivity; Evaluation; Goals; Healthcare Systems; Human; Image; Imaging Techniques; Investigation; Life; Magnetism; Malignant Neoplasms; Mammary Neoplasms; Mammography; Measurement; Methods; Noise; Normal Range; Normal tissue morphology; Outcome; Pathology; Patients; Performance; Physiologic pulse; Property; Radiation; Reporting; Research; Resolution; Roentgen Rays; Sampling; Screening for cancer; Sensitivity and Specificity; Signal Transduction; Specificity; Specimen; System; Techniques; Technology; Testing; Time; Tissue Differentiation; Tissues; Ultrasonic Transducer; Ultrasonography; United States; Woman; Work; anticancer research; base; biomagnetism; breast lesion; cancer imaging; clinical Diagnosis; clinical application; cost effective; design; electric impedance; imaging modality; in vivo; innovation; magnetic field; malignant breast neoplasm; mortality; novel; novel strategies; performance tests; research study; screening; simulation; soft tissue; tissue phantom; tomography; tumor

DESCRIPTION (provided by applicant): Breast cancer is one of the most life-threatening tumors among women in U.S. There is considerable evidence that early diagnosis and treatment of breast cancer can significantly increase chances of survival. While X-ray mammography is the current standard screening technique, it is limited by its poor soft tissue differentiation and radiation exposure. Patients with positive mammographic findings require a biopsy for definitive diagnosis, and it was reported that biopsies of breast lesions identified in mammography screenings are negative for malignancy in a significant portion of the patients. We propose to develop a novel, cost-effective, non-ionizing, high resolution, and high specificity imaging system for imaging electrical conductivity by integrating biomagnetism with ultrasound (magnetoacoustic tomography with magnetic induction: MAT-MI) for screening and early detection of breast cancer. This proposed development is based on the experimental evidence that cancerous tissue shows significantly higher electrical conductivity value than normal and benign tissue. In this R21 project, we propose to explore and develop a 3-dimensional (3D) multi-excitation MAT-MI (meMAT-MI) system and evaluate it in computer simulations, phantom experiments, and breast specimen imaging, for the purpose of achieving high resolution, high specificity electrical impedance imaging throughout the volume with a cost effective system realization for breast cancer detection. In the proposed 3D meMAT-MI, the object is located in a static magnetic field and a time-varying pulsed magnetic field. Multiple pulsed magnetic stimulations will be applied to the object, which induce eddy current distributions in the object. Consequently, the sample will emit acoustic waves by the Lorentz force based on the interplay of induced currents and applied magnetic fields. The acoustic signals are collected around the object during multi-excitation to reconstruct images related with the electrical conductivity distribution in the object. Through multi-excitation using magnetic energy, we propose to reconstruct the complete electrical conductivity profiles throughout the volume of the object. We will develop and optimize the novel 3D meMAT-MI system, and assess its feasibility in computer simulations and phantom experiments. We will also test directly its performance in imaging breast tumors in human breast specimens. High resolution imaging of electrical impedance distribution is of significance for a variety of applications in biomedical research and clinical diagnosis, such as early cancer detection. The successful development of a high-resolution, non-ionizing, cost-effective electrical impedance imaging system will have a significant impact to screening and early detection of breast cancer.

描述（由申请人提供）：乳腺癌是美国妇女中最威胁生命的肿瘤之一，有大量证据表明，早期诊断和治疗乳腺癌可以显着增加生存机会。尽管X射线乳房X线摄影是当前的标准筛查技术，但它受其软组织分化和辐射暴露不良的限制。乳房X线摄影阳性的患者需要进行活检以进行明确的诊断，据报道，在大量患者中，在乳房X线摄影筛查中鉴定出的乳腺病变活检对恶性肿瘤呈阴性。我们建议开发一种新型，成本效益，非离子化，高分辨率和高特异性成像系统，以通过将生物磁性与超声（磁性层析成像与磁性感应：MAT-MI：MAT-MI：MAT-MI）相结合，以筛查和早期检测到乳腺癌的超声（MAT-MI）。该提出的发展是基于实验证据，即癌组织比正常组织和良性组织显示出明显更高的电导率值。在这个R21项目中，我们建议探索和开发3维（3D）多激发MAT-MI（MEMAT-MI）系统，并在计算机仿真，幻影实验和乳房标本成像中对其进行评估，以实现高分辨率，高特异性，高特异性电气电气成像，均具有成本有效的乳腺癌症，以实现乳腺癌的高度有效的系统实现。在拟议的3D MEMAT-MI中，该物体位于静态磁场和随时间变化的脉冲磁场中。多个脉冲磁刺激将应用于物体，该物体诱导物体中的涡流分布。因此，样品将根据诱导电流和施加的磁场的相互作用来通过洛伦兹力发出声波。在多启示过程中，在物体周围收集声信号，以重建与物体中的电导率分布相关的图像。通过使用磁能的多兴激素，我们建议在整个物体的整个体积中重建完整的电导率曲线。我们将开发和优化新型的3D MEMAT-MI系统，并评估其在计算机模拟和幻影实验中的可行性。我们还将直接测试其在人类乳房标本中乳腺肿瘤成像的性能。电阻抗分布的高分辨率成像对于生物医学研究和临床诊断（例如早期癌症检测）的多种应用至关重要。成功开发高分辨率，非离子化，具有成本效益的电阻抗成像系统将对筛查和早期发现乳腺癌产生重大影响。