Malaria Vector Population Genetic Division and Vector Competence in Hainan Island

海南岛疟疾媒介群体遗传划分及媒介能力

• 批准号: 8460098
• 负责人: LIWANG CUI
• 金额: $ 5.93万
• 依托单位: PENNSYLVANIA STATE UNIVERSITY, THE
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-04-18 至 2014-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8460098
• 关键词: Adult; Agriculture; Anopheles Genus; Area; Beds; Behavior; Bite; China; Collaborations; Communities; Competence; Complex; Country; Culicidae; Development; Disease; Disease Outbreaks; Doctor of Philosophy; Drug resistance; Ecology; Effectiveness; Epidemiology; Evolution; Falciparum Malaria; Frequencies; Genetic Vectors; Grant; Heterogeneity; Infection; Insecticides; International; Island; Knowledge; Malaria; Measures; Membrane; Methods; Mixed Function Oxygenases; Monitor; Mosquito Control; Mutation; Myanmar; Parasites; Parents; Pattern; Pest Control; Plasmodium falciparum; Population; Population Genetics; Postdoctoral Fellow; Province; Public Health; Research; Resistance; Resistance development; Rest; Role; Sampling; Site; Smell Perception; Southeastern Asia; Specificity; Structure; Students; System; Testing; Thailand; Training; United States National Institutes of Health; Universities; anthropogenesis; base; chemotherapy; environmental change; experience; feeding; genetic analysis; improved; innovation; interest; microbial; parent grant; population genetic structure; preference; programs; pyrethroid; research study; resistance mechanism; response; skills training; socioeconomics; southeast Asian; tool; transmission process; vector; vector control

Malaria Vector Population Genetic Division and Vector Competence in Hainan Island Project Summary Malaria is a significant public health problem and impediment to socioeconomic development in countries of the Greater Mekong Subregion of Southeast Asia. The tremendous geographical heterogeneity of malaria epidemiology in this region is associated with diverse vector systems with different vectorial capacities for the parasites. As the major measures of malaria control strategies, insecticide-treated bed nets and indoor sprays have resulted in pyrethroid resistance, and greatly reshaped the mosquito community and population structures. In Hainan Island of China, extensive use of insecticides for malaria control has led to an initially sharp decrease and recently rebound of Anopheles miminus, the key malaria vector in China and Southeast Asia. Not only has the insecticide-driven vector population succession restructured the vector community, but also the resurged mosquito population displayed altered biting preference. Based on these observations, we hypothesize that recent intensive malaria vector control measures and agricultural pest control measures have caused a significant ecological species succession and population genetic bottleneck of malaria vectors in Hainan Island, China. Therefore, this FIRCA proposal aims to take the advantage of geographical isolation of Hainan Island to elucidate the evolution of a major malaria vector in response to insecticide control. We will determine whether the different ecotypes of An. minimus from hilly and plain areas have different vectorial competence to Plasmodium falciparum infections. This study will provide invaluable information for the prediction of mosquito evolution in response to insecticides-based mosquito control measures in other malaria-endemic regions of Southeast Asia. The proposed research will contribute to building research capacity by training one Ph.D. student and one postdoc fellow from the endemic country. This project will be carried out primarily in China at Chongqing Normal University in collaboration with Dr. Bin Chen, as an extension of NIH grant U19 AI089672.

海南岛的疟疾媒介种群遗传分割和媒介能力 项目摘要 疟疾是一个重大的公共卫生问题，也是社会经济的障碍 东南亚大湄公河区域的发展。巨大的 该地区疟疾流行病学的地理异质性与多样化有关 寄生虫具有不同矢量能力的矢量系统。作为主要措施 疟疾控制策略，杀虫剂处理的床网和室内喷雾剂已导致 拟除虫菊酯抵抗，并大大改造了蚊子社区和人口结构。 在中国海南岛，广泛使用杀虫剂来控制疟疾 急剧下降和最近的Anopheles Miminus反弹，中国的关键疟疾载体 和东南亚。不仅具有杀虫剂驱动的载体种群继任 重组了矢量社区，但显示的蚊子人口也发生了变化 咬人的偏好。基于这些观察，我们假设最近的强化疟疾 向量控制措施和农业有害生物控制措施已引起了重要的 海南疟疾媒介的生态物种继承和种群遗传瓶颈 中国岛。因此，该FIRCA提议旨在利用地理位置 隔离海南岛，以阐明主要疟疾载体的演变 杀虫剂控制。我们将确定AN的不同生态型。 Minimus来自Hilly 普通区和恶性疟原虫感染具有不同的矢量能力。这 研究将为响应蚊子进化的预测提供宝贵的信息 基于杀虫剂的蚊子控制措施 亚洲。拟议的研究将通过培训一位博士学位来促进建立研究能力。 学生和一名来自地方性国家的博士后研究员。该项目将进行 主要在中国在重庆师范大学与Bin Chen博士合作作为 NIH授予U19 AI089672的扩展。