Endectocides for Malaria Control

用于控制疟疾的杀虫剂

• 批准号: 7512454
• 负责人: BRIAN David FOY
• 金额: $ 14.7万
• 依托单位: COLORADO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-07-01 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7512454
• 关键词: Acids; Adult; Africa South of the Sahara; African; Age; Agonist; Agriculture; Anopheles Genus; Anopheles gambiae; Area; Bionomics; Blood; Characteristics; Chloride Channels; Cities; Class; Communities; Culicidae; Developed Countries; Developing Countries; Development; Dose; Drug toxicity; Exhibits; Feeding behaviors; Female; Filarial Elephantiases; Fogs; Generations; Glutamates; Habits; Health; Helminths; Housing; Human; Infection; Insecticide Resistance; Insecticides; Ivermectin; Lactones; Link; Logistic Regressions; Malaria; Malathion; Mammals; Measures; Membrane; Methods; Modeling; Molecular Target; Nematoda; Neuromuscular Junction; Onchocerciasis; Pesticides; Pharmaceutical Preparations; Plasmodium; Population; Property; Public Health; Rate; Research; Resistance; Rest; Safety; Score; Senegal; Sporozoites; Structure; Survival Rate; Survivors; Testing; Time; Treatment Protocols; cost; day; disease transmission; drug testing; egg; feeding; killings; mathematical model; milbemycin; milbemycins; mosquitocidal; moxidectin; novel; prevent; pyrethroid; research study; stem; transmission process; vector

DESCRIPTION (provided by applicant): Malaria continues to sicken and kill millions of people around the world every year, and is an especially intractable problem in sub-Saharan Africa. Mosquito adulticides are the bedrock of effective malaria control because they are relatively cost-effective, they can be applied to walls or bednets, and they target the most critical variable in malaria transmission models, adult mosquito survivor rates. However, widespread insecticide resistance and continued malaria transmission require the development of novel adulticides and novel ways to apply them. Endectocides are broad spectrum, low toxicity drugs with combined anti-helminthic and anti-ectoparasitic properties and are currently given to human populations for onchocerciasis and lymphatic filariasis control. Current endectocides that act as agonists to glutamate and GABA-gated chloride ion channels in mosquito myoneural junctions, could also be effectively used for malaria control in sub- Saharan Africa and would have certain major advantages over other adulticides due to their molecular targets, how they would be administered to the human population, and the bionomics of African malaria vectors. This research is intended to determine the effective doses of glutamate and GABA-gated chloride ion channel agonist endectocides (macrocyclic lactones, milbemycins, nodulasporamides) for killing adult Anopheles spp. when administered via an artificial bloodmeal. Secondly, mass-ivermectin administration for onchocerciasis control in Southeastern Senegal will be tested for mosquitocidal effects on bloodfeeding adult Anopheles spp. in the field, and that this effect will transiently interrupt malaria transmission in the local community. PUBLIC HEALTH RELEVANCE This project seeks to develop novel methods to control malaria in sub-Saharan Africa by evaluating current anti-helminth drugs for activity against African malaria vectors and testing their effects in a natural field experiment.

描述（由申请人提供）：疟疾每年继续生病并杀死全球数百万人，这是撒哈拉以南非洲特别棘手的问题。蚊子成人剂是有效疟疾控制的基岩，因为它们相对具有成本效益，可以应用于墙壁或床头，并且针对疟疾传播模型，成人蚊子幸存者率的最关键变量。然而，广泛的杀虫剂耐药性和持续的疟疾传播需要开发新的成人剂和新颖的应用方法。端肠肽是广谱，低毒性药物，具有抗螺旋和抗脑寄生虫的合并性，目前被赋予人群的脑凝集和淋巴丝虫病控制。当前充当蚊子肌神经交界中谷氨酸和GABA门控氯离子通道的激动剂的端肽也可以有效地用于撒哈拉以南非洲亚地区的疟疾控制，并且由于其分子靶标而对其他成年人的人类群体，对人类群体和非洲人的群体群体和非洲人的群体，并且对其他成人群体具有某些重大优势。这项研究旨在确定有效剂量的谷氨酸和GABA门控氯离子通道激动剂端肽（大环内酮，米尔贝霉素，结节型寄生虫）用于杀死成年的蚊帐。当通过人造血液施用时。其次，将测试塞内加尔东南部的大量膜片蛋白对尾尾con虫的控制，以测试对血液喂养成人肛门spp的蚊子效果。在该领域，这种影响将在当地社区中瞬时中断疟疾传播。公共卫生相关性该项目旨在通过评估当前的抗螺旋药物来控制撒哈拉以南非洲疟疾的新方法来控制非洲疟疾媒介的活性并在自然野外实验中测试其影响。