Ivermectin for Malaria Control

伊维菌素用于控制疟疾

基本信息

批准号：
8843336
负责人：
BRIAN David FOY
金额：
$ 50.26万
依托单位：
COLORADO STATE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-02-15 至 2017-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8843336
关键词：
Accounting Address Adult Affect Africa African Age Animals Anopheles Genus Anopheles gambiae Apolipoproteins C Artemisinins Bite Blood Cessation of life Combined Modality Therapy Communities Companions Culicidae Data Drops Economic Burden Environment Exploratory/Developmental Grant for Diagnostic Cancer Imaging Filarial Elephantiases Foundations Future Goals Health Human Human Bites Insecta Insecticides Intervention Invertebrates Ivermectin Knowledge Laboratories Laboratory Study Lactones Length Malaria Measures Methods Modeling Molecular Target Morbidity - disease rate Mosquito-borne infectious disease Muscle Fibers Nematoda Neuromuscular Junction Neurons Onchocerciasis Oral Outcome Paralysed Parasites Pharmaceutical Preparations Plasmodium falciparum Population Population Study Public Health Research Infrastructure Residual state Resistance Resources Rest Safety Schedule Seasons Senegal Sporozoites Structure Study models Time Work artemisinine combat feeding field study glutamate-gated chloride channel health economics killings malaria transmission mortality novel postsynaptic neurons programs reproductive research study resistance mechanism success tool transmission process treatment trial vector vector control vector transmission

项目摘要

DESCRIPTION (provided by applicant): The public health and economic burden imposed by mosquito-borne diseases on the developing world, and especially Africa, is enormous. Malaria accounts for the largest portion of global mosquito-borne disease morbidity and mortality. There is an urgent need for novel vector control tools that reduce malaria transmission by mosquitoes in distinct ways from traditional insecticides, including tools that have new molecular targets in mosquitoes, new modes of delivery to the mosquito, and tools that can target transmission by vectors not well- controlled by insecticide-treated nets or indoor residual spraying. To be maximally effective in resource- constrained environments of the developing world, such tools must also be able to integrate with existing malaria control interventions and existing human health infrastructures. Our broad hypothesis is that ivermectin used in human de-worming campaigns in African villages, and which we have shown can disrupt malaria parasite transmission in Senegalese villages, could serve as one of these promising new tools. Ivermectin is an oral drug, already given by mass administration to humans in the developing world for onchocerciasis control, and malaria vectors can ingest and be killed by this drug when they bite humans after these mass drug administrations. Our data suggests that more frequent administrations of ivermectin in malaria-endemic communities would result in sustained reductions in malaria parasite transmission. To get to this goal, a thorough examination of the ivermectin effects against malaria vectors in the field and laboratory is necessary. We propose two specific aims: Aim 1: Perform field population studies in Senegal on the effects of ivermectin ingested by wild malaria vectors. Aim 2: Perform laboratory and modeling studies on the effects ivermectin may have on mosquitoes and malaria parasite transmission.

描述（由申请人提供）：蚊子传播疾病对发展中国家，尤其是非洲造成的公共卫生和经济负担是巨大的。疟疾占全球蚊子传播疾病发病率和死亡率的最大部分。迫切需要新型的矢量控制工具，以与传统杀虫剂不同的方式减少蚊子传播的疟疾，包括在蚊子中具有新分子靶的工具，向蚊子传递的新模式，以及可以针对矢量传播的工具由杀虫剂处理的网或室内残留喷涂良好控制。要在发展中国家的资源约束环境中最大程度地有效，此类工具还必须能够与现有的疟疾控制干预措施和现有的人类健康基础设施集成。我们广泛的假设是，在非洲村庄的人类衰落运动中使用的伊维菌素，我们已经表明的可能会破坏塞内加尔村庄的疟疾寄生虫传播，可以作为这些有希望的新工具之一。 ivermectin是一种口服药物，已经由大规模管理给发展中国家的人类控制，以控制尾cer虫，而疟疾媒介在这些大众药物管理后咬人时可能会摄取并被这种药物杀死。我们的数据表明，在疟疾流行群落中，伊维菌素的施用更频繁会导致疟疾寄生虫传播的持续减少。为了实现这一目标，有必要彻底检查伊维菌素对现场和实验室中疟疾媒介的影响。我们提出了两个具体目标：目标1：在塞内加尔进行现场人群研究对伊维菌素摄入的伊维菌素的影响。 AIM 2：对伊维菌素对蚊子和疟原虫传播的影响进行实验室和建模研究。

项目成果

期刊论文数量（14）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Ivermectin: a complimentary weapon against the spread of malaria?

DOI：
10.1080/14787210.2017.1271713
发表时间：
2017-03
期刊：
Expert review of anti-infective therapy
影响因子：
5.7
作者：
Alout H;Foy BD
通讯作者：
Foy BD

Establishment of the Ivermectin Research for Malaria Elimination Network: updating the research agenda.

DOI：
10.1186/s12936-015-0691-6
发表时间：
2015-06-11
期刊：
Malaria journal
影响因子：
3
作者：
Chaccour CJ;Rabinovich NR;Slater H;Canavati SE;Bousema T;Lacerda M;Ter Kuile F;Drakeley C;Bassat Q;Foy BD;Kobylinski K
通讯作者：
Kobylinski K

Age and prior blood feeding of Anopheles gambiae influences their susceptibility and gene expression patterns to ivermectin-containing blood meals.

DOI：
10.1186/s12864-015-2029-8
发表时间：
2015-10-15
期刊：
BMC genomics
影响因子：
4.4
作者：
Seaman JA;Alout H;Meyers JI;Stenglein MD;Dabiré RK;Lozano-Fuentes S;Burton TA;Kuklinski WS;Black WC 4th;Foy BD
通讯作者：
Foy BD

Analysis of near infrared spectra for age-grading of wild populations of Anopheles gambiae.