Physiology Core

生理学核心

• 批准号: 8501410
• 负责人: David Francis Dolan
• 金额: $ 4.96万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-08-01 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8501410
• 关键词: Acoustic Nerve; Action Potentials; Address; Adoption; Animals; Behavior assessment; Behavioral; Biochemical; Cellular biology; Chemicals; Cochlear Implants; Collaborations; Complex; Data; Development; Disease; Education; Equilibrium; Equipment; Evoked Potentials, Auditory, Brain Stem; Experimental Designs; Faculty; Grant; Group Meetings; Hearing; Hearing problem; Individual; Laboratories; Lead; Link; Martens; Measurement; Measures; Methodology; Methods; Molecular; Molecular Biology; Molecular Genetics; Nerve; Noise; Physiological; Physiology; Preparation; Procedures; Productivity; Publications; Reflex action; Research; Research Personnel; Research Project Grants; Resource Sharing; Schedule; Sensory; Services; Smell Perception; Structure; Students; Taste Perception; Testing; Training; Work; base; improved; meetings; novel; otoacoustic emission; prevent; round window

The Physiology Core will provide critical support for assessment of function through four aims. Aim 1: Enhance and extend the quality and scope of the individual research projects: The Core will provide and facilitate application of methods and approaches that are not within the expertise of individual investigators but can address hypotheses in their studies. The most common assessment is of auditory brain stem response (ABR) with more in-depth measures, e.g. otoacoustic emissions, efferent reflex, round window noise, cochlear microphonics, cochlear whole-nerve action potentials and endolymphatic potential also available. The Core also develops conditions for and coordinates noise exposures of animals. Aim 2: Improve the efficiency and productivity of ongoing research within the user group: The Core will provide centralized, well maintained equipment and facilities and shared resources for various physiological measurements. It will also provide training of students, fellows and staff in the basic methods (for example ABR), avoiding pitfalls and facilitating accurate interpretation of results. Expert staff will perform and/or assist in measurement of complex physiological functions. Aim 3: Develop methods and approaches to meet current and anticipated user needs: The Core will work with individual investigators to modify and develop applications and contribute to experimental design to select most appropriate physiological parameters. The Core will now offer a new screen to test basic vestibular function developed by Dr. King (consultant) to meet needs of our user base. Aim 4: Provide education, develop interactions and new collaborations: The Core will continue to train students, fellows and staff in routine procedures and facilitate adoption of new ones. Meetings with faculty, students and staff provide a forum for education and information on novel and advanced methodologies as do presentations at the regularly scheduled larger group meetings of Core A (Scientific Synergy Core). The Physiology Core also aids in the interpretation and the preparation of results for publications. Together with the Cell and Molecular Biology Core (Core C), the Physiology Core provides an essential link of genetic, molecular and biochemical data to structure and function.

生理学核心将通过四个目标为功能评估提供关键支持。 目标 1：提高和扩展个别研究项目的质量和范围：核心将提供并促进应用不属于个别研究者专业知识但可以解决其研究中的假设的方法和途径。最常见的评估是听觉脑干反应（ABR），具有更深入的测量，例如还提供耳声发射、传出反射、圆窗噪声、耳蜗微音学、耳蜗全神经动作电位和内淋巴电位。该核心还为动物的噪音暴露制定条件并进行协调。 目标 2：提高用户组内正在进行的研究的效率和生产力：核心将为各种生理测量提供集中的、维护良好的设备和设施以及共享资源。它还将为学生、研究员和工作人员提供基本方法（例如 ABR）方面的培训，避免陷阱并促进结果的准确解释。专家人员将执行和/或协助测量复杂的生理功能。 目标 3：开发满足当前和预期用户需求的方法和方法：核心将与个别研究人员合作修改和开发应用程序，并为实验设计做出贡献，以选择最合适的生理参数。 Core 现在将提供由 King 博士（顾问）开发的新屏幕来测试基本前庭功能，以满足我们用户群的需求。 目标 4：提供教育、发展互动和新的合作：核心将继续对学生、研究员和工作人员进行常规程序培训，并促进新程序的采用。与教师、学生和工作人员的会议为有关新颖和先进方法的教育和信息提供了一个论坛，就像在定期安排的核心 A（科学协同核心）大型小组会议上的演示一样。生理学核心还有助于解释和准备出版物结果。 生理学核心与细胞和分子生物学核心（核心 C）一起，提供了遗传、分子和生化数据与结构和功能之间的重要联系。