CORE--AUDITORY PHYSIOLOGY

核心--听觉生理学

• 批准号: 6966780
• 负责人: David Francis Dolan
• 金额: $ 18.79万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-01 至 2010-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6966780
• 关键词: aging; auditory threshold; biomedical facility; hearing; physiology; presbycusis

The Physiology Core will provide integrated services to the researchers of the individual projects. The Core personnel will work to coordinate physiological testing of animals with each individual project directors. The auditory brainstem response will be the primary method to evaluate auditory sensitivity across all projects. The endocochlear potential will be measured to address the status of stria vascularis in young and old mice. The Physiology Core will also coordinate noise exposures of animals with respect to each investigator's needs for exposures that will produce either temporary (ITS) or permanent (PTS) threshold shifts to meet the needs of the projects. The Physiology Core will provide all of the standard materials and services to accomplish the physiological measurements. The results obtained from the procedures described in this core will be analyzed and coordinated for statistical significance with the Data Management team and they will serve as consultants to discuss interpretation of data and correlation with other results. The Core will analyze and prepare graphs for presentation at scientific forums and publication in scientific journals. To further promote efficient and successful Core operation, frequent meetings will be used to discuss progress in research, emerging techniques and assist in future directions. Procedures are in place for scheduling and prioritization of services and quality control. The Histology Core and Physiology Core will work closely together to coordinate physiological and morphological characterization of animals under experimental conditions.

生理学核心将为各个项目的研究人员提供综合服务。核心人员将与每个项目主管协调动物的生理测试。听觉脑干反应将是评估所有项目听觉敏感性的主要方法。将测量耳蜗内电位以了解年轻和年老小鼠的血管纹状态。生理学核心还将根据每个研究者的暴露需求来协调动物的噪声暴露，这将产生临时（ITS）或永久（PTS）阈值变化以满足需要 的项目。生理学核心将提供所有标准材料和服务来完成生理测量。从本核心描述的程序中获得的结果将与数据管理团队进行分析和协调，以实现统计显着性，他们将作为顾问讨论数据的解释以及与其他结果的相关性。核心将分析和准备图表，以便在科学论坛上展示和在科学期刊上发表。为了进一步促进高效和成功的核心运作，将经常召开会议来讨论研究进展， 新兴技术并协助未来的方向。已制定服务安排和优先级以及质量控制的程序。组织学核心和生理学核心将密切合作，协调实验条件下动物的生理和形态特征。