Tracking development of global visual function using high-density eeg

使用高密度脑电图跟踪全局视觉功能的发展

• 批准号: 8303645
• 负责人: Lynne Kiorpes
• 金额: $ 26.7万
• 依托单位: NEW YORK UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8303645
• 关键词: Age; Amblyopia; Animal Model; Animals; Area; Autistic Disorder; Behavioral; Biological Assay; Brain; Brain imaging; Clinical; Cognitive; Data; Databases; Development; Dorsal; Electrodes; Electroencephalography; Emotional; Evaluation; Future; Generations; Goals; Head; Human; Human Development; Image; Individual; Infant; Knowledge; Link; Literature; MRI Scans; Macaca; Magnetic Resonance Imaging; Measures; Methodology; Methods; Modeling; Monkeys; Motion; Neurons; Newborn Infant; Organism; Outcome; Pathway interactions; Pattern; Population; Premature Infant; Primates; Relative (related person); Research; Resolution; Scanning; Series; Signal Transduction; Solutions; Source; Staging; Stimulus; Stream; Surface; System; Techniques; Technology; Time; Translating; Vision; Visual; Visual Pathways; Work; behavior measurement; cognitive function; density; design; disability; extrastriate; functional status; improved; in vivo; neurodevelopment; neuromechanism; neurophysiology; nonhuman primate; novel; premature; programs; relating to nervous system; sensor; vision development; visual process; visual processing

DESCRIPTION (provided by applicant): The aim of this proposal is to support a novel research program that will allow the integration of behavioral and electrophysiological assays of visual development with modeling of brain development to identify the neural correlates of developmental changes in visual function. We propose to adapt existing methodology of high-density EEG recording for use in an animal model. The goal of the project is to use a non-invasive assay for studying brain development in vivo that will allow direct comparison with behavioral measures of visual function and which will also directly correlate with neurophysiological data obtained through other studies. The resulting data can be directly translated to questions of brain development in humans, and the methodology can be extended to the study of brain maturation in other domains and with other populations. To accomplish our goal, we will develop technology to enable high-density EEG signals to be acquired from infant nonhuman primates. We will generate head models from high-resolution structural MRI scans at a number of developmental stages so that the sources of the EEG signals can be identified across ages. Using the methodology we develop, we will study the development of the major extrastriate visual processing pathways, the dorsal and ventral streams. We will then directly link changes in neural activity to behaviorally measured development of visual function. This project will yield four important outcomes. First, we will obtain the first direct comparison between non-invasively obtained signals reflecting brain development and the development of behavioral visual function. Second, we will provide information on the sources of these signals for direct comparison with single neuron recordings and EEG data obtained in human infants. Third, we will acquire a complete series of developmental brain images that can be used as a normative database in future research. Fourth, we will adapt a very important technology for use in small primates, which will be directly relevant to the problem of evaluation of brain function, for clinical or research purposes, in very premature infants or other small, neurologically challenged individuals. PUBLIC HEALTH RELEVANCE: This proposed work is designed to reveal the pattern and timing of development of specific brain areas and pathways, and link patterns of behavioral and electrophysiological development with knowledge of underlying neural mechanisms. The technology to be developed will inform future studies of brain development in human infants, with specific relevance to very small, very premature, or neurologically challenged newborns.

描述（由申请人提供）：该提案的目的是支持一个新的研究计划，该计划将允许将视觉发育的行为和电生理测定与大脑发育建模相结合，以识别视觉功能发育变化的神经相关性。我们建议适应用于动物模型中的高密度脑电图记录的现有方法。该项目的目的是使用非侵入性测定在体内研究大脑发育，这将允许直接比较视觉功能的行为度量，并且还将与通过其他研究获得的神经生理学数据直接相关。所得数据可以直接转化为人类大脑发育问题，该方法可以扩展到其他领域和其他人群中大脑成熟的研究。为了实现我们的目标，我们将开发技术以使高密度的脑电图信号从婴儿的非人类灵长类动物中获取。我们将在许多发育阶段中从高分辨率结构性MRI扫描中生成头部模型，以便可以在各个时代识别出EEG信号的来源。使用我们开发的方法，我们将研究主要的腹腔外视觉处理途径，背和腹流的发展。然后，我们将直接将神经活动的变化与视觉功能的行为测量发展联系起来。该项目将产生四个重要的结果。首先，我们将获得反映大脑发育和行为视觉功能发展的非侵入性获得的信号之间的第一个直接比较。其次，我们将提供有关这些信号来源的信息，以直接与人类婴儿获得的单个神经元记录和脑电图数据进行直接比较。第三，我们将获得一系列完整的发展大脑图像，这些图像可以用作未来研究的规范数据库。第四，我们将适应一项非常重要的技术，可用于小型灵长类动物，这将与非常过早的婴儿或其他小型，神经学挑战的个体评估，出于临床或研究目的的评估问题直接相关。 公共卫生相关性：这项拟议的工作旨在揭示特定大脑区域和途径发展的模式和时机，以及将行为和电生理发展的模式与潜在神经机制的知识联系起来。要开发的技术将为未来对人类婴儿的大脑发育的研究提供信息，该研究与非常小的，非常过早或神经学挑战的新生儿具有特定的相关性。