Tracking development of global visual function using high-density eeg

使用高密度脑电图跟踪全局视觉功能的发展

基本信息

批准号：
8451301
负责人：
Lynne Kiorpes
金额：
$ 10.31万
依托单位：
NEW YORK UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-04-01 至 2015-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8451301
关键词：
Age Amblyopia Animal Model Animals Area Autistic Disorder Behavioral Biological Assay Brain Brain imaging Clinical Cognitive Data Databases Development Dorsal Electrodes Electroencephalography Emotional Evaluation Future Generations Goals Head Human Human Development Image Individual Infant Knowledge Link Literature MRI Scans Macaca Magnetic Resonance Imaging Measures Methodology Methods Modeling Monkeys Motion Neurons Newborn Infant Organism Outcome Pathway interactions Pattern Population Premature Infant Primates Relative (related person)Research Resolution Scanning Series Signal Transduction Solutions Source Staging Stimulus Stream Surface System Techniques Technology Time Translating Vision Visual Visual Pathways Work behavior measurement cognitive function density design disability extrastriate functional status improved in vivo neurodevelopment neuromechanism neurophysiology nonhuman primate novel premature programs relating to nervous system sensor vision development visual process visual processing

项目摘要

Project Summary The aim of this proposal is to support a novel research program that will allow the integration of behavioral and electrophysiological assays of visual development with modeling of brain development to identify the neural correlates of developmental changes in visual function. We propose to adapt existing methodology of high- density EEG recording for use in an animal model. The goal of the project is to use a non-invasive assay for studying brain development in vivo that will allow direct comparison with behavioral measures of visual function and which will also directly correlate with neurophysiological data obtained through other studies. The resulting data can be directly translated to questions of brain development in humans, and the methodology can be extended to the study of brain maturation in other domains and with other populations. To accomplish our goal, we will develop technology to enable high-density EEG signals to be acquired from infant nonhuman primates. We will generate head models from high-resolution structural MRI scans at a number of developmental stages so that the sources of the EEG signals can be identified across ages. Using the methodology we develop, we will study the development of the major extrastriate visual processing pathways, the dorsal and ventral streams. We will then directly link changes in neural activity to behaviorally measured development of visual function. This project will yield four important outcomes. First, we will obtain the first direct comparison between non-invasively obtained signals reflecting brain development and the development of behavioral visual function. Second, we will provide information on the sources of these signals for direct comparison with single neuron recordings and EEG data obtained in human infants. Third, we will acquire a complete series of developmental brain images that can be used as a normative database in future research. Fourth, we will adapt a very important technology for use in small primates, which will be directly relevant to the problem of evaluation of brain function, for clinical or research purposes, in very premature infants or other small, neurologically challenged individuals.

项目摘要该提案的目的是支持一个新颖的研究计划，该计划将允许行为和通过对大脑发育建模的视觉发展的电生理测定，以识别神经视觉功能发展变化的相关性。我们建议适应现有的高级方法论密度脑电图记录用于动物模型。该项目的目的是使用非侵入性测定在体内研究大脑发育，这将允许直接与视觉功能的行为度量进行比较并且还将与通过其他研究获得的神经生理数据直接相关。结果数据可以直接转化为人类大脑发育问题，方法可以是扩展到其他领域和其他人群中大脑成熟的研究。为了实现我们的目标，我们将开发技术以使高密度的脑电图信号从中获取婴儿非人类灵长类动物。我们将从高分辨率的结构MRI扫描中生成头部模型发育阶段的数量，以便可以跨年龄识别出EEG信号的来源。使用我们开发的方法，我们将研究主要的视觉外部处理的开发途径，背和腹流。然后，我们将直接将神经活动的变化与行为上联系起来测量的视觉功能发展。该项目将产生四个重要的结果。首先，我们将获得反映大脑发育的非侵入性获得的信号与行为视觉功能的发展。其次，我们将提供有关这些信号来源的信息为了直接与人类婴儿获得的单个神经元记录和脑电图数据进行比较。第三，我们会的获取一系列完整的发育脑图像，这些图像将来可以用作规范数据库研究。第四，我们将适应一项非常重要的技术，用于小型灵长类动物，这将直接与大脑功能的评估问题相关，出于临床或研究目的，非常过早婴儿或其他小型神经挑战的人。