CSHL Eukaryotic DNA Replication Conference

CSHL真核DNA复制会议

基本信息

批准号：
8595427
负责人：
DAVID J. STEWART
金额：
$ 0.5万
依托单位：
COLD SPRING HARBOR LABORATORY
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-08-01 至 2014-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8595427
关键词：
American Animal Genetics Archives Area Asians Biochemistry Biology Cell Cycle Cell Cycle Progression Cell Nucleus Cell division Cells Chromatin Structure Chromosomes Collaborations Complement Cytomegalovirus DNA DNA Damage DNA Repair DNA Replication Damage DNA biosynthesis Data Development Disease Drosophila genus Drug resistance Elements Ensure Environment Epigenetic Process Eukaryota European Event Faculty Feedback Fostering Gene Amplification Generations Genetic Genetic Materials Genome Genome Stability Genomic Instability Genomics Goals Growth Herpesviridae Human Herpesvirus 4 International Internet Investigation Laboratories Lead Learning Length of Stay Life Maintenance Malignant Neoplasms Mammalian Cell Minority Mitotic Cell Cycle Molecular Molecular Biology Oral Organism Papillomavirus Participant Peer Review Play Polyomavirus Postdoctoral Fellow Process Proteins Published Comment Radiation therapy Reading Regulation Replication Origin Replication-Associated Process Research Research Institute Research Personnel Role S Phase Schedule Science Scientist Seasons Selection Criteria Senior Scientist Series Signal Transduction Simian virus 40 Staging Structure System Systems Biology Time Vascular Plant Viral Woman Work Xenopus Yeasts abstracting anticancer research base biological adaptation to stress biological research cancer cell career chemotherapy chromatin modification experience fundamental research graduate student improved interest lectures meetings novel strategies posters public health relevance rapid growth repaired response single molecule success symposium telomere tumor unpublished works

项目摘要

DESCRIPTION (provided by applicant):: 2013 CONFERENCE ON EUKARYOTIC DNA REPLICATION & GENOME MAINTENANCE This conference will be the 14th biennial meeting on Eukaryotic DNA Replication and Genome Maintenance and follows the highly successful meetings that have been held at Cold Spring Harbor every second year since September 1987. It is the only regularly occurring meeting that is exclusively focused on eukaryotic DNA replication. Because of this focus, the meeting has played a major role in the rapid growth in our understanding of the eukaryotic DNA replication process and how it is integrated into the cell division cycle. This year's conference will be devoted to fundamental research topics related to chromosome duplication, structure and function, and will include important areas of biological research in the areas of cell cycle and growth control, genomic amplification, and the response of the replication apparatus to DNA damage. Starting with the 2007 meeting, we placed an increased emphasis on the central role of DNA replication in the DNA damage and replication stress response and the strategies used by cells to minimize the threats to genomic integrity arising from DNA replication. The rapid convergence of the DNA replication and DNA damage response fields makes this a timely meeting. The format of the meeting will ensure that recent results will be communicated and discussed face-to-face, which will enhance progress and collaboration. The participation of young investigators and minority and women scientists is strongly encouraged. The 2013 meeting will include a diverse array of topics, systems, and approaches including studies of: (1) chromosomal replication and gene amplification in organisms as diverse as yeast, Drosophila, Xenopus and mammalian cells; (2) the replication of viral chromosomes, including SV40, polyomavirus, cytomegalovirus, herpesvirus, papillomaviruses, and Epstein-Barr virus; (3) control of DNA replication in the cell cycle; (4) structure and function of the chromosomal elements controlling replication including origins of replication and telomeres; (5) connections between DNA replication and the cell cycle, chromatin modifications, development, and cancer; (6) mechanisms that control genomic integrity including DNA replication checkpoints and post-replication DNA repair; (7) novel approaches including genomics, systems biology, and single molecule studies. Since DNA replication is crucial to cell division, uncontrolled growth is a hallmark of tumors, S phase is a major target for chemo- and radiotherapy and errors in DNA replication lead to genomic instability, the relevance of this meeting to cancer research, and ultimately to improved therapies, cannot be overemphasized. Replication of DNA is a fundamental process in all (eukaryotic) life. This meeting will focus on understanding the mechanism by which this process occurs, and how DNA replication contributes to genome stability and maintenance of the epigenetic state of a cell. The intellectual merits of this conference include the opportunity for leading investigators at all stages of their scientific careers to share and discuss their latest results and concepts. The informal peer review in oral and poster sessions is invaluable in providing rapid feedback that will fruitfully steer and accelerate future research. This conference also provides ample opportunity for learning and building collaborations - no parallel sessions are planned and so all attendees share a common experience, while the secluded venue maximizes the likelihood of productive scientific exchange. Large conferences generally can have significant impact in their field. Unique aspects of this conference that have particularly broad impact are the active participation of younger scientists who will particularly benefit from the opportunity to present their latest ideas. The conference archive (Leading strand video archive accessible by the internet) allows participants to share aspects of the conference with their colleagues who were unable to attend while protecting the right of the presenting authors to present unpublished research.

描述（申请人提供）:: 2013真核DNA复制和基因组维护会议本会议将是第14次关于真核DNA复制和基因组维持的双年两年一次会议，并遵循自1987年9月以来每隔第二年在冷春港举行的非常成功的会议，这是唯一的定期会议。这是唯一的会议。由于这一重点，这次会议在我们对真核DNA复制过程的快速增长中发挥了重要作用，以及如何将其整合到细胞分裂周期中。今年的会议将致力于与染色体复制，结构和功能有关的基本研究主题，并将包括在细胞周期和生长控制，基因组扩增和复制设备对DNA损伤的反应的重要领域。从2007年的会议开始，我们越来越重视DNA复制在DNA损伤和复制应力反应中的核心作用以及细胞使用的策略，以最大程度地减少DNA复制引起的基因组完整性的威胁。 DNA复制和DNA损伤响应场的快速收敛使这是及时的相遇。会议的格式将确保将最近的结果面对面传达和讨论，这将增强进度和协作。强烈鼓励年轻的调查人员以及少数民族和女性科学家的参与。 2013年的会议将包括各种各样的主题，系统和方法，包括：（1）像酵母，果蝇，Xenopus和哺乳动物细胞一样多样化的生物体中的染色体复制和基因扩增；（2）病毒染色体的复制，包括SV40，多瘤病毒，巨细胞病毒，疱疹病毒，乳头瘤病毒和爱泼斯坦 - 巴尔病毒；（3）控制细胞周期中DNA复制；（4）控制复制的染色体元件的结构和功能，包括复制和端粒的起源；（5）DNA复制与细胞周期，染色质修饰，发育和癌症之间的联系；（6）控制基因组完整性的机制，包括DNA复制检查点和复制后DNA修复；（7）包括基因组学，系统生物学和单分子研究在内的新方法。由于DNA复制对于细胞分裂至关重要，因此不受控制的生长是肿瘤的标志，S期是化学和放疗和DNA复制中错误的主要目标，导致基因组不稳定性，这次会议与癌症研究的相关性，最终与改善的疗法有关，不能过分强调。 DNA的复制是所有（真核）寿命的基本过程。这次会议将重点放在理解该过程的机制上，以及DNA复制如何有助于基因组稳定性和细胞表观遗传状态的维持。这次会议的智力优点包括在其科学职业的各个阶段领先的研究人员分享和讨论其最新结果和概念的机会。口头和海报会议中的非正式同行评审对于提供快速反馈的反馈非常宝贵，这些反馈将有效地转向并加速未来的研究。这次会议还提供了足够的学习和建设合作机会 - 没有计划平行的会议，因此所有与会者都有共同的经验，而僻静的场地则最大程度地提高了生产性科学交流的可能性。大型会议通常会对自己的领域产生重大影响。这次会议的独特方面具有特别广泛的影响，这是年轻科学家的积极参与，他们将特别受益于提出最新想法的机会。会议档案档案（由互联网可以访问的领先的链视频档案馆）使参与者可以与他们的同事分享会议的各个方面，这些同事在保护介绍作者的权利提出未发表的研究的同时无法参加。