CSHL Eukaryotic DNA Replication & Genome Maintenance Conference

CSHL 真核 DNA 复制

• 批准号: 9330469
• 负责人: DAVID J. STEWART
• 金额: $ 0.3万
• 依托单位: COLD SPRING HARBOR LABORATORY
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-08-10 至 2018-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9330469
• 关键词: Alpha Cell; American; Animal Genetics; Archives; Area; Asians; Award; Biochemistry; Biology; Cell Cycle; Cell Cycle Progression; Cell Nucleus; Cells; Chromatin; Chromatin Structure; Chromosomal Instability; Chromosomes; Collaborations; Complement; DNA replication fork; Data; Development; Diné Nation; Disease; Drosophila genus; Drug resistance; Ensure; Environment; Epigenetic Process; Eukaryota; European; Event; Faculty; Feedback; Fostering; Gene Amplification; Generations; Genetic; Genetic Materials; Genetic Transcription; Genome; Genome Stability; Genomic Instability; Genomics; Goals; Growth; Industrialization; International; Internet; Investigation; Laboratories; Lead; Learning; Length of Stay; Life; Maintenance; Malignant Neoplasms; Mammalian Cell; Minority; Molecular; Molecular Biology; Mutagenesis; Oral; Organism; Participant; Peer Review; Play; Postdoctoral Fellow; Process; Proteins; Published Comment; Radiation therapy; Regulation; Repair Material; Replication Initiation; Replication Origin; Replication-Associated Process; Research; Research Institute; Research Personnel; Role; S Phase; Schedule; Science; Scientist; Selection Criteria; Senior Scientist; Series; Signal Transduction; Site; Stress; Structure; Syndrome; System; Time; Vascular Plant; Woman; Work; Xenopus; Yeasts; anticancer research; biological adaptation to stress; biological research; biophysical techniques; cancer cell; career; cell growth; chromosome replication; event cycle; experience; fundamental research; genome integrity; graduate student; improved; interest; lectures; meetings; posters; programs; rapid growth; repaired; resistance mechanism; response; success; symposium; tumor; unpublished works

2017 CSHL CONFERENCE ON EUKARYOTIC DNA REPLICATION & GENOME MAINTENANCE PROJECT SUMMARY/ABSTRACT This conference will be the 16th biennial meeting on Eukaryotic DNA Replication and Genome Maintenance and follows the highly successful meetings that have been held at Cold Spring Harbor every other year since September 1987. It is the only regularly occurring meeting that is exclusively focused on eukaryotic DNA replication. Because of this focus, the meeting has played a major role in the rapid growth in our understanding of the eukaryotic DNA replication process and how it is integrated into the cell division cycle. This year's conference will be devoted to fundamental research topics related to chromosome duplication, structure and function, and will include important areas of biological research in the areas of cell cycle and growth control, genomic amplification, and the response of the replication apparatus to DNA damage. As the field has moved forward over the past decade, we have placed an increased emphasis on the central role of DNA replication in the DNA damage and replication stress response, and strategies used by cells to minimize threats to genomic integrity arising from DNA replication. The rapid convergence of the DNA replication and DNA damage response fields makes this a timely meeting. The format of the meeting will ensure that recent results are communicated and discussed face-to-face, which will enhance progress and collaboration. The participation of young investigators, minority, and women scientists is strongly encouraged. The 2017 meeting will include a diverse array of topics, systems, and approaches including studies of chromosomal replication and gene amplification in organisms as diverse as yeast, Drosophila, Xenopus and mammalian cells. Sessions will cover (1) Replication Initiation and Origin Site specification; (2) the Replication Program, Chromatin, and Development (3) Mechanisms that Initiate Replication and ensure fidelity of Replication Fork Progression; (4) how cells respond to Replication Stalling and Replication Fork Stress; (5) integration of DNA replication with the Cell Cycle and with Transcription; (6) the response to DNA damage including Checkpoints and Post-Replication DNA repair; (7) effects on Genome Instability and Mutagenesis when replication is deregulated; (8) Diseases arising from dysfunctional DNA replication, including Cancer and other Chromosome Instability syndromes. Uncontrolled DNA replication is a hallmark of tumors and errors in DNA replication lead to genomic instability, while the process of chromosome replication is a major target for chemo- and radiotherapy. The relevance of this meeting to cancer research, and ultimately to improved therapies, cannot be overemphasized. Replication of DNA is a fundamental process in all (eukaryotic) life. This meeting will focus on understanding the mechanism by which this process occurs, and how DNA replication contributes to genome stability and maintenance of the epigenetic state of a cell. The intellectual merits of this conference include the opportunity for leading investigators at all stages of their scientific careers to share and discuss their latest results and concepts. The informal peer review in oral and poster sessions is invaluable in providing rapid feedback that will fruitfully steer and accelerate future research. This conference also provides ample opportunity for learning and for building collaborations. We do not plan parallel sessions within the schedule so that all attendees share a common experience, while the secluded venue maximizes the likelihood of productive scientific exchange. Large, established conferences generally can have significant impact, and this Cold Spring meeting has undoubtedly driven forward research in DNA replication. Unique aspects of this conference that have particularly broad impact are the active participation of younger scientists who will particularly benefit from the opportunity to present their latest ideas. The conference archive (Leading strand video archive accessible by the internet) allows participants to share aspects of the conference with their colleagues who were unable to attend while protecting the right of the presenting authors to present unpublished research.

2017 CSHL真核DNA复制和基因组维护会议 项目摘要/摘要 这次会议将是关于真核DNA复制和基因组的第16届双年展会议 维护并遵循每次在冷泉港举行的非常成功的会议 自1987年9月以来的另一年。这是唯一一次专注于专注于 真核DNA复制。由于这一重点，会议在快速增长中发挥了重要作用 我们对真核DNA复制过程以及如何整合到细胞分裂周期中的理解。 今年的会议将致力于与染色体复制有关的基础研究主题， 结构和功能，将包括细胞周期领域的生物学研究的重要领域， 生长控制，基因组扩增以及复制设备对DNA损伤的反应。作为 在过去的十年中，田野一直向前发展，我们越来越重视 DNA损伤和复制应力反应中的DNA复制，以及细胞使用的策略来最小化 DNA复制引起的对基因组完整性的威胁。 DNA复制的快速收敛和 DNA损伤响应领域使这是及时的会议。会议的格式将确保最近 结果进行交流和讨论，这将增强进度和协作。这 强烈鼓励年轻的调查人员，少数民族和女科学家的参与。 2017年会议将包括各种各样的主题，系统和方法，包括研究 像酵母，果蝇，爪蟾和酵母一样多样化的生物体中的染色体复制和基因扩增 哺乳动物细胞。会议将涵盖（1）复制启动和原点站点规范； （2）复制 程序，染色质和开发（3）启动复制并确保保真度的机制 复制叉进展； （4）细胞如何响应复制的停滞和复制叉应力； （5） DNA复制与细胞周期和转录的整合； （6）对DNA损伤的反应 包括检查点和复制后DNA修复； （7）对基因组不稳定性和诱变的影响 如果复制放松管制； （8）由功能失调的DNA复制引起的疾病，包括癌症和 其他染色体不稳定性综合征。不受控制的DNA复制是肿瘤和错误的标志 DNA复制导致基因组不稳定性，而染色体复制的过程是 化学和放射疗法。这次会议与癌症研究的相关性，最终是改善 疗法，不能过分强调。 DNA的复制是所有（真核）寿命的基本过程。这次会议将重点 了解该过程发生的机制，以及DNA复制如何有助于基因组 细胞表观遗传状态的稳定性和维持。这次会议的智力优点包括 在科学职业的各个阶段，领先的研究人员的机会分享和讨论他们的最新 结果和概念。口头和海报会议中的非正式同行评审对于提供快速的速度是无价的 反馈将有效地转向并加速未来的研究。这次会议还提供了足够的 学习和建立合作的机会。我们不计划在时间表中的平行会议 因此，所有与会者都有共同的经验，而僻静的场地则最大程度地提高了 生产性科学交流。 大型，建立的会议通常会产生重大影响，并且这次寒冷的会议已经 无疑是DNA复制的前进研究。这次会议的独特方面 特别广泛的影响是年轻科学家的积极参与，他们将特别受益于 有机会提出他们的最新想法。会议档案库（可访问的领先链视频档案库 互联网）允许参与者与他们的同事分享会议的各个方面 在保护介绍作者提出未发表研究的同时参加。