The Effects of Smoking and Expectancy on ERP Measures of Attentional Bias

吸烟和期望对注意力偏差 ERP 测量的影响

• 批准号: 8082786
• 负责人: Jason D Robinson
• 金额: $ 17.84万
• 依托单位: UNIVERSITY OF TX MD ANDERSON CAN CTR
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-08-15 至 2013-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8082786
• 关键词: Address; Adult; Affect; Affective; Area; Association Learning; Attention; Brain; Cells; Cigarette; Clinical Trials Design; Cognitive; Cognitive Science; Cues; Data; Deception; Dependence; Development; Digit structure; Dose; Double-Blind Method; Electroencephalography; Emotional; Emotions; Environment; Equilibrium; Ethical Issues; Event-Related Potentials; Expectancy; Exposure to; Female; Gender; Grant; Instruction; Knowledge; Laboratories; Legal; Measures; Mentors; Mentorship; Methodology; Neurobiology; Nicotine; Nicotine Dependence; Patient Self-Report; Peripheral Nervous System; Pharmaceutical Preparations; Placebos; Process; Property; Psychophysiology; Reaction Time; Relapse; Research; Research Personnel; Research Training; Resources; Sampling; Scientist; Sex Characteristics; Slide; Smoke; Smoker; Smoking; Stimulus; Techniques; Technology; Tobacco use; Training; University of Texas M D Anderson Cancer Center; Woman; Work; addiction; career; craving; cue reactivity; deprivation; design; distraction; drug of abuse; expectation; experience; health disparity; human subject; indexing; information processing; men; multidisciplinary; neurobehavior; neurobehavioral; programs; public health relevance; relating to nervous system; response; skills; visual information

DESCRIPTION (provided by applicant): The focus of this proposal is to provide the applicant with the skills, experience, and mentoring to become an independent researcher with a focus on understanding the neurobehavioral determinants of nicotine dependence. The training plan outlined in this proposal will allow me to expand my skills by providing an opportunity to become proficient in the use of event-related potential (ERP) electroencephalography (EEC) techniques to study attentional and emotional mechanisms related to nicotine dependence. This work will be conducted at the University of Texas M. D. Anderson Cancer Center, where I will be mentored by distinguished scientists in the field of nicotine dependence. This multidisciplinary team will provide oversight of my research and training experiences by providing specific expertise in the areas of neurobehavior, ERP, attentional biases, and gender differences of smoking. The focus of the Research Plan is to gain a greater understanding of the attentional biases of smokers in order to expand our knowledge of how drug and affective cues help to maintain neural sensitization to drugs of abuse. The proposed study would be the first to evaluate the attentional bias of smokers using a within-subjects balanced placebo design, allowing for the separation of the effects of nicotine from the effects of smoking cues on ERP attentional response to smoking and affective cues. The specific aims of this proposal are (a) to distinguish the effects of nicotine's pharmacological properties from those resulting from learned associations on the attentional distraction by smoking and affective cues in dependent smokers, (b) to determine whether gender differences exist in the attentional distraction by smoking and affective cues, (c) to determine whether the expectation of imminent tobacco use increases the attentional distraction by smoking and affective cues, and (d) to assess whether ERP measures of attentional distraction by smoking and affective cues correlate with traditional self-reported measures of nicotine dependence, craving, and affect. PUBLIC HEALTH RELEVANCE: Smoking dependence is thought to be maintained by the brain's attentional bias towards cues in the environment that remind the dependent invidual of smoking. This study will use event-related potential (ERP) EEG technology to investigate these attentional biases and circumstances that provoke them.

描述（由申请人提供）：该提案的重点是为申请人提供成为独立研究人员的技能、经验和指导，重点是了解尼古丁依赖的神经行为决定因素。本提案中概述的培训计划将使我有机会熟练使用事件相关电位 (ERP) 脑电图 (EEC) 技术来研究与尼古丁依赖相关的注意力和情绪机制，从而扩展我的技能。这项工作将在德克萨斯大学 MD 安德森癌症中心进行，在那里我将得到尼古丁依赖领域杰出科学家的指导。这个多学科团队将通过提供神经行为、ERP、注意力偏差和吸烟性别差异等领域的具体专业知识来监督我的研究和培训经验。该研究计划的重点是更好地了解吸烟者的注意力偏差，以扩大我们对药物和情感线索如何帮助维持对滥用药物的神经敏感性的了解。拟议的研究将是第一个使用受试者内平衡安慰剂设计来评估吸烟者注意力偏差的研究，从而将尼古丁的影响与吸烟线索对 ERP 对吸烟和情感线索的注意力反应的影响分开。该提案的具体目的是（a）区分尼古丁的药理学特性与吸烟者注意力分散的习得关联所产生的影响和情感线索，（b）确定注意力分散中是否存在性别差异通过吸烟和情感线索，(c) 确定即将吸烟的预期是否会增加吸烟和情感线索造成的注意力分散，以及 (d) 评估 ERP 是否衡量吸烟和情感线索造成的注意力分散情感线索与尼古丁依赖、渴望和情感的传统自我报告测量相关。 公共健康相关性：吸烟依赖被认为是通过大脑对环境中提醒吸烟者吸烟的线索的注意力偏向来维持的。这项研究将使用事件相关电位（ERP）脑电图技术来调查这些注意力偏差和引发它们的环境。