Core C: Data Management and Statistical Core

核心C：数据管理与统计核心

• 批准号: 9753085
• 负责人: MARK Andrew ESPELAND
• 金额: $ 22.95万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9753085
• 关键词: Adult; Affect; African American; Alzheimer' s Disease Core Center; American; Archives; Biomedical Computing; Biometry; Capsicum; Clinical; Clinical Data; Clinical Trials; Cognition; Cognitive; Cognitive aging; Cohort Studies; Collaborations; Communities; Comprehensive Cancer Center; Computational Biology; Data; Data Management Resources; Data Quality; Data Set; Database Management Systems; Databases; Dementia; Development; Diabetes Mellitus; Education; Ensure; Family; Fostering; Genetic; Goals; Health Professional; Image Analysis; Impaired cognition; Infrastructure; Intervention; Investments; Knowledge; Leadership; Libraries; Measurement; Metabolic; Metabolic Diseases; Methodology; Mission; Modeling; Multicenter Studies; Outcome; Participant; Pathogenesis; Positioning Attribute; Prevention; Prevention strategy; Reporting; Research; Research Design; Research Infrastructure; Research Personnel; Resources; Risk; Science; Secure; Specific qualifier value; Standardization; Structure; System; Target Populations; Therapeutic; Training; Vascular Diseases; Work; analytical method; biomathematics; cohort; collaborative environment; data exchange; data management; data resource; design; experience; forest; high risk; novel; precision medicine; programs; recruit; synergism; transmission process; treatment strategy; vascular factor

Data Management and Statistical Core (Core C) – Project Summary The mission of Data Management and Statistical (DMS) Core is to promote excellence in the Wake Forest ADCC by providing outstanding data management, biomedical computing, and analytical support to ADCC investigators and affiliates. The Wake Forest ADCC has four overarching aims: 1) to establish a comprehensive integrated research infrastructure at Wake Forest focused on identifying the causes of AD, and on the potential prevention or treatment of AD; 2) to provide within this infrastructure specialized resources to accelerate research on the hypothesis that metabolic and vascular factors contribute to AD pathogenesis and on the development of novel interventions; 3) to optimize the participation of African American adults in research and educational programs to better understand and treat the causes underlying the increased risk of AD and dementia in the African American community; and 4) to provide education regarding AD and related dementias to health professionals, researchers, afflicted adults and their families, and the community at large. To accomplish these objectives, the DMS Core will 1) provide and maintain state-of-the-art resources for data management, study management, and reporting to ensure the highest data quality and study integrity and to increase the efficiency and impact of ADCC research; 2) provide expertise and collaboration in study design, clinical trials, biostatistics and other analytical sciences (including measurement, image analysis, modeling, computational biology, and biomathematics) to Wake Forest ADCC projects; 3) develop and maintain efficient and secure platforms for the exchange of data within the Wake Forest ADCC and with NACC, NCRAD, other ADCs, and AD researchers; 4) collaborate on the dissemination of Wake Forest ADCC study findings and the engagement of targeted cohorts; and 5) mine our library of data from major studies of cognition and AD to facilitate efficient study design, provide a platform for pooled analyses, and provide resources to facilitate the development of AD researchers. The DMS Core has a breadth of relevant experience, a diverse analytical team, a strong collaborative environment, many extant resources for study management, an extensive archive of cognitive data from many major studies, and a proven robust data management infrastructure. These are all essential facets and notable strengths of our proposed Wake Forest ADCC.

数据管理和统计核心（核心C） - 项目摘要 数据管理和统计（DMS）核心的使命是在Wake Forest中促进卓越 通过为ADCC提供出色的数据管理，生物医学计算和分析支持，ADCC 调查人员和分支机构。 Wake Forest ADCC具有四个总体目的：1）建立一个 维克森林的全面综合研究基础设施致力于确定AD的原因， 关于AD的潜在预防或治疗； 2）在此基础架构中提供专业资源 加速对代谢和血管因素有助于AD发病机理和 关于新干预的发展； 3）优化非洲裔美国成年人的参与 研究和教育计划，以更好地理解和治疗增加的原因 非裔美国人社区的AD和痴呆症； 4）提供有关广告及相关的教育 对卫生专业人员，研究人员，成年人及其家人以及整个社区的痴呆症。 为了实现这些目标，DMS核心将1）提供并维护数据的最新资源 管理，研究管理和报告，以确保最高数据质量和研究完整性 提高ADCC研究的效率和影响； 2）提供研究设计方面的专业知识和协作， 临床试验，生物统计学和其他分析科学（包括测量，图像分析，建模， 计算生物学和生物护理学）唤醒森林ADCC项目； 3）发展和保持高效 和安全平台，以在Wake Forest ADCC和NACC，NCRAD，其他其他方面交换数据 ADC和广告研究人员； 4）合作传播Wake Forest ADCC研究结果和 参与目标队列； 5）从认知的主要研究和广告中挖掘我们的数据库 促进有效的研究设计，为汇总分析提供平台，并提供资源以促进 广告研究人员的发展。 DMS核心具有相关经验的广度，潜水员分析 团队，一个强大的协作环境，许多用于研究管理的广泛资源，一个广泛的档案 来自许多主要研究的认知数据以及可靠的强大数据管理基础架构。这些都是 我们拟议的Wake Forest ADCC的基本方面和明显的优势。