Collaborative RNAi

协同RNAi

基本信息

批准号：
8469424
负责人：
STEPHANIE E MOHR
金额：
$ 17.2万
依托单位：
DANA-FARBER CANCER INST
依托单位国家：
美国
项目类别：
财政年份：
资助国家：
美国
起止时间：
至
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/8469424
关键词：
Address Adopted Area Biological Biological Assay Biology Cancer Biology Cancer Center Cancer Center Support Grant Categories Cell Death Cell Lineage Cell division Cells Complex Dana-Farber Cancer Institute Data Quality Data Set Development Doctor of Philosophy Drosophila genus Gene Expression Gene Targeting Genes Genetic Transcription Growth Instruction Interphase Cell Investigation Ions Lead Learning Libraries Link Malignant Neoplasms Mammalian Cell Messenger RNA Methods Molecular Molecular Biology Pathway interactions Phenotype RNA Interference Reagent Research Research Personnel Resource Sharing Screening Result Services Technology Tumor Suppressor Genes Validation Viral Vector anticancer research base cancer cell cancer genome cancer prevention cancer therapy cell growth gene function instrument meetings member operation screening small hairpin RNA tool tumor progression

项目摘要

PROJECT SUMM/\RY (See instructions): Understanding the basic biological mechanisms that underlie the development and progression of cancer is fundamental to finding better approaches to cancer prevention and treatment. High-throughput RNA interference (RNAi) screening is a state-of-the-art method for large-scale investigation of gene function, including identification of new cancer-related genes and pathways. The Collaborative RNAi Core offers a single portal through which DF/HCC members are educated about the use of RNAi screening and resulting datasets to study cancer biology, learn about specific screening options to meet their research needs and access RNAi facilities that had not been consistently available to Cancer Center members. The Core also coordinates the operations and administrative functions of these primarily independent RNAi units. This Core was created during the project period due to high member demand and is presented as a new Established Shared Resource in this proposal. Director: Stephanie Mohr, PhD(HMS) Category: 1.20 (Molecular Biology) and 1.37 (RNAi Screening)

项目汇总/\RY（参见说明）：了解癌症发生和进展的基本生物学机制对于寻找更好的癌症预防和治疗方法至关重要。高通量 RNA 干扰 (RNAi) 筛选是大规模研究基因功能的最先进方法，包括鉴定新的癌症相关基因和通路。协作 RNAi 核心提供了一个单一门户，通过该门户，DF/HCC 成员可以了解如何使用 RNAi 筛查和所得数据集来研究癌症生物学、了解满足其研究需求的特定筛查选项以及访问尚未持续可用的 RNAi 设施癌症中心成员。核心还协调这些主要独立的 RNAi 单位的运作和管理职能。由于会员需求量大，该核心是在项目期间创建的，并在此提案中作为新建立的共享资源提出。主任：Stephanie Mohr，博士（HMS）类别：1.20（分子生物学）和 1.37（RNAi 筛选）