DEVELOP NSLS-II BEAMLINES FOR MACROMOLECULAR CRYSTALLOGRAPHY

开发用于高分子晶体学的 NSLS-II 束线

• 批准号: 8363415
• 负责人: ROBERT M SWEET
• 金额: $ 5.75万
• 依托单位: BROOKHAVEN SCIENCE ASSOC-BROOKHAVEN LAB
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-01 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8363415
• 关键词: Address; Advisory Committees; Automation; Biological Sciences; Biology; Calculi; Caliber; Crystallography; Floor; Fruit; Funding; Future; Grant; Light; National Center for Research Resources; Optics; Phase; Principal Investigator; Progress Reports; Reporting; Research; Research Infrastructure; Resources; Source; Specific qualifier value; Spectrum Analysis; Structure; Synchrotrons; Time; United States National Institutes of Health; Universities; Work; base; beamline; cost; design; meetings; working group

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Objectives The objectives stated in the recent renewal proposal are these: create a draft plan for the final build out of NSLS-II for life sciences, create a conceptual design for a Phase-1 buildup of macromolecular crystallography beamlines at NSLS-II, establish advisory committees, specify details, of floor layouts for two or three adjacent sectors, plan the timing of the move of NSLS beamline components to the three-pole wigglers at NSLS-II, and specify a Lab and Office Building to serve a Biology Village on the NSLS-II floor. Although these objectives were warmly endorsed by the review panel, we were not directly funded to pursue any of these objectives. Nevertheless, with limited resources available to us, we commenced effort to address a subset of these objectives and report them here because of their importance to the integrated project. Results -- Three proposals were approved by the NSLS-II SAC: Two were for a canted-pair of undulators. FMX would produce a beam as small as one micron diameter to serve the most difficult problems https://www.px.nsls.bnl.gov/for_mxbat/BDP_2010_FMX_21.pdf. AMX would be highly accessible and efficient, having top quality automation. A third approved beamline was SM3, to employ a three-pole wiggler source and to provide correlated MX and optical spectroscopy. The approved proposals were prepared by a group, calling ourselves the MX Working Group, which met regularly over the previous two years, working to design especially undulator beamlines. A nearly complete roster includes: Lonny Berman, NSLS and NSLS-II; Robert Sweet, Dieter Schneider, Howard Robinson, Allen Orville, Alexei Soares, Annie Heroux, Deborah Stoner-Ma, BNL Biology; Mark Chance, Michael Sullivan, Wuxian Shi, Case Western Reserve; Wayne Hendrickson, Columbia University and NSLS-II; Marc Allaire, Vivian Stojanoff, Jean Jakoncic, Kun Qian, NSLS; Qun Liu, John Schwanof, Randy Abramowitz; Columbia Univ. Plans  A full time-line of our efforts are the the full Research Progress report. Now we wait. We have made clear that we in the PXRR are prepared to do whatever is necessary to bring these plans to fruition. We also work with The Working Group and others to prepare a scientific case for BER/DOE support of future beamlines. We see this as the next best possibility for finding funding for the approved MX/Spectroscopy beamline known as SM3. Significance  Our longstanding efforts to create a life-science presence at NSLS-II are bearing fruit. The new facilities there will be the best in the world for all x-ray-based studies of biomolecular structure.

该副本是利用资源的众多研究子项目之一 由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持 而且，副投影的主要研究员可能是其他来源提供的 包括其他NIH来源。 列出的总费用可能 代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。 Objectives The objectives stated in the recent renewal proposal are these: create a draft plan for the final build out of NSLS-II for life sciences, create a conceptual design for a Phase-1 buildup of macromolecular crystallography beamlines at NSLS-II, establish advisory committees, specify details, of floor layouts for two or three adjacent sectors, plan the timing of the move of NSLS beamline components to NSLS-II的三极摇摆人，并指定了一个实验室和办公大楼，可以在NSLS-II地板上为生物学村提供服务。尽管这些目标得到了评论小组的热烈认可，但我们并未直接资助这些目标。 但是，由于我们可用的资源有限，我们开始努力解决这些目标的一部分，并在此处报告，因为它们对集成项目的重要性。 结果 - NSLS-II SAC批准了三个建议：两个是 对于倾斜的倾斜对象。 FMX会产生一张小至一微米直径的光束，以服务最困难的问题https://www.px.nsls.bnl.gov/for_mxbat/bdp_2010_fmx_21.pdf。 AMX具有高质量自动化的高度访问和高效。第三个批准的光束线是SM3，用于采用三极摇摆器源并提供相关的MX和光谱法。 批准的提案是由一个小组编写的，称自己为MX工作组，该小组在过去两年中定期开会，努力设计尤其是悬崖梁。一个几乎完整的名册包括：Lonny Berman，NSLS和NSLS-II；罗伯特·斯威特（Robert Sweet），迪特·施耐德（Dieter Schneider），霍华德·罗宾逊（Howard Robinson），艾伦·奥尔维尔（Allen Orville），亚历克西（Alexei Soares），安妮·赫鲁克斯（Annie Heroux），黛博拉·斯托纳·马（Deborah Stoner-Ma），BNL Biyology； Mark Chance，Michael Sullivan，Wuxian Shi，Case Western Reserve；韦恩·亨德里克森（Wayne Hendrickson），哥伦比亚大学和NSLS-II； Marc Allaire，Vivian Stojanoff，Jean Jakoncic，Kun Qian，NSLS； Qun Liu，John Schwanof，Randy Abramowitz；哥伦比亚大学。 计划的全职工作是完整的研究进度报告。现在我们等待。我们已经明确指出，我们在PXRR中准备采取任何必要的事情来实现这些计划。我们还与工作组和其他人合作，准备一个科学案例，以支持未来光束线的BER/DOE支持。我们认为这是为批准的MX/Spectroscopy Beamine找到资金的下一个最佳可能性，称为SM3。 在NSLS-II建立生命科学的存在方面，我们的长期努力具有果实。 所有基于X射线的生物分子结构研究将是世界上最好的设施。