MACROMOLECULAR STRUCTURE DETERMINATION - GENERAL USERS

大分子结构测定 - 普通用户

基本信息

批准号：
8363359
负责人：
ROBERT M SWEET
金额：
$ 130.89万
依托单位：
BROOKHAVEN SCIENCE ASSOC-BROOKHAVEN LAB
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-07-01 至 2012-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8363359
关键词：
3-Dimensional ATP phosphohydrolase Adenine Alphavirus Amyloid beta-Protein Aspartate Bacillus (bacterium)Bacterial RNA Bacteriophage N4 Binding Binding Proteins Bypass COPII-Coated Vesicles CYP2B4 gene Carbamyl Phosphate Chromatin Remodeling Factor Coenzyme A Collection Complex Crystallography DNA DNA Repair Enzymes DNA biosynthesis DNA-Directed DNA Polymerase DNA-Directed RNA Polymerase DR1 gene Data Data Collection Development Elements Entamoeba histolytica Epidermal Growth Factor Receptor Fatty Acid Desaturases Fibrinogen Flavivirus Funding Gene Silencing Generations Grant Growth Guanosine Triphosphate Phosphohydrolases H-Meromyosin HIV HIV-1 HLA-DR4 Antigen Histidine-Specific tRNA Histocompatibility Antigens Class II Human Human Resources Immune Insulin Laws Lesion Ligands Light MADD gene Membrane Proteins Micrococcal Nuclease Mismatch Repair Molecular Structure Muramidase National Center for Research Resources O-GlcNAc transferase Peptide Hydrolases Peptides Phosphoglucomutase Porphobilinogen Synthase Principal Investigator Prolactin Receptor Protein Synthesis Inhibitors Proteins Protons RIPK2 gene RNA Research Research Infrastructure Research Personnel Resolution Resources Ricinus communis Roentgen Rays Signal Transduction Source Spectrum Analysis Structure Synchrotrons T-Cell Receptor United States National Institutes of Health abstracting analog anti-cancer therapeutic base cost desaturase design env Gene Products helicase human BCAR1 protein inhibitor/antagonist kinase inhibitor microbial mutant novel protein complex psychostimulant receptor binding research study sensor tRNA guanylyltransferase triabin

项目摘要

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. This subproject consists of a group of projects for which either abstracts were not available, or the total use was less than 0.1% of grant dollars, carried out by investigators who each consumed beamtime for the collection of x-ray diffraction data for 3-dimensional crystal structure solving. The investigators are included in the list of personnel, and they are the ones not identified with any other subproject. The investigators/subprojects for which their total use was less than 0.1% of grant dollars include the following: Thomas Steitz Structural Studies of tRNA-his Guanylyltransferase Stefan Riedl SHEP1/p130cas complex Deena Oren Fibrinogen/Abeta Victoria Robinson Structural Description of Novel Bacterial GTPases Gregory Bowman Crystal structure of human DDX3X helicase with ATP analogs Lucy Waskell Structure and spectroscopy of F429H mutant of cytochrome p450 2B4 Carolyn Cohen Heavy meromyosin Janice Pata Lesion-bypass DNA polymerases. Alex Bohm Mcv T-ag complex with DNA Prasanna Kolatkar Structure of Pax6 on non-canonical DNA elements Rudresh Acharya Crystal structure determination of M2 proton channel Yi Lu Lysozyme + DNA Huilin Li Outer membrane protein usher Ursula Ramirez Porphobilinogen synthase Yili Li HLA-DR4 complex with GP100 peptide Jurgen Sygusch The adenine riboswitch Victor Khangulov Internal Ionizable Residues in Staphylococcal nuclease Christopher Law Binding of dopaminergic psychostimulant to LeuT Yorgo Modis Flavivirus envelope protein and complexes John Shanklin Ivy Desaturase construct 2 Thomas Steitz Structural Studies of the 50S ribosomal subunit with substrate analogues Yorgo Modis Microbial ligand recognition by innate immune sensors Alba Guarne Cabello Studies of ADEPA with mutH Evan Kantrowitz Structure of Aspartate Trancarbamoylase from Bacillis subtilis with the substrate carbamoyl phosphate Karin Reinisch DENN-1 in complex with Rab35 Matthew Cordes Triabin-like Lipocalin 4 Edward Arnold Structural studies of HIV-1 RT and RNAP Byung ha Oh ST_Cas7 Yili Li Complex structure of CD4 and MHC class II molecule DR1 Liang Tang Structural studies of bacterial signal-transduction protein complexes Piotr Sliz Structure determination of human O-GlcNAc transferase and its complexes with peptides and inhibitors. Janice Pata Error-prone DNA synthesis Susan Buchanan Using the structure of MtmOIV for development of anti-cancer therapeutics Yong Xiong HIV factors and cellular interacting protein partners Ursula Ramirez Porphobilinogen synthase Christopher Hill Structural studies of Rpn13/Rpn2/Uch37complexes James Parsons PabB Karen Allen Beta-phosphoglucomutase Huei-Jiun Li 1,4-dihydroxy-2-naphthoyl-CoA synthase (MenB) in complex with inhibitors Jonathan Goldberg Structural Study of the Outer Shell of the COPII Vesicle Coat Alexei Soares Multi crystal experiments with insulin Bryan Nixon Mechanism of force generation by the AAA+ ATPase NtrC1 Seth Darst Bacterial RNA polymerase paused elongation complex Gregory Verdine Bacillus caldotenax UvrB (DNA Repair enzyme) Luis Brieba De Castro Structure of Inbitor of cistein Protease 1 from Entamoeba histolytica (EhICP1) Zhaocai Zhou EGFR kinase inhibitors Barbara Gerratana SibS Leemor Joshua-Tor Characterization of protein complexes involved in RNA induced transcriptional gene silencing Christopher Hill Partial Chromatin Remodeling Complex Jessica Bell FhbB MAD data collection Hongmin Li RIP2 binding protein Elias Lolis Structural basis for pH-dependent human Prolactin receptor recognition Kannan Natarajan Structures of T cell receptors, unliganded and in complex with MHC molecules John Shanklin Castor Bean wild-type fatty-acid desaturase Alba Guarne Cabello DNA Mismatch repair Mridhu Indic X-Ray Structure of FadL Mutants Yili Li NKp30 and Its ligand B7-H6 Elias Lolis MIF Enzymatic Inhibition and Mechanisms Andrew VanDemark DShrm SD2 domain Joseph Ippolito High Resolution Studies of the Large Ribosomal Subunit Bound to Newly Designed Inhibitors of Protein Synthesis Karen Allen Light chain inhibitor design Joseph Marcotrigiano Alphavirus replication proteins Katsuhiko Murakami Structure of bacteriophage N4 RNA polymerase2 and DNA complex Stevan Hubbard Growth Receptor Binding protein 14 RAPH - Ras Complex

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。对该子项目的主要支持和子弹的主要研究者可能由其他来源（包括其他NIH来源）提供。该子项目列出的总成本可能代表了子项目使用的估计中心基础设施的估计数量，而不是NCRR赠款向子项目或副标理人员提供的直接资金。该子项目由一组项目组成，该项目要么无法摘要，要么总使用量的总使用量的0.1％，该项目由研究人员进行，每个项目都消耗了Beamtime，以收集X射线衍射数据，以用于三维晶体结构解决方案。调查人员被包括在人员名单中，而没有任何其他子弹标识的人。其总使用量少于赠款的0.1％的调查人员/副本包括以下内容： thomas steitz tRNA的结构研究 - his guanylyltransferase酶 Stefan Riedl Shep1/p130Cas综合体 Deena Oren纤维蛋白原/Abeta 新型细菌GTPases的维多利亚·罗宾逊的结构描述与ATP类似物的人DDX3X解旋酶的Gregory Bowman晶体结构露西·沃斯克尔（Lucy Waskell 卡罗琳·科恩（Carolyn Cohen）重毛霉素珍妮丝·帕塔（Janice Pata）病变 - 甲型DNA聚合酶。 Alex Bohm MCV T-AG与DNA Prasanna kolatkar pax6在非典型DNA元素上的结构 M2质子通道的Rudresh Acharya晶体结构测定 yi lu溶菌酶 + DNA Huilin Li外膜蛋白Usher Ursula Ramirez斑岩脂蛋白合酶 Yili li Hla-Dr4配合物与GP100肽尤尔根·塞古斯（Jurgen Sygusch）腺嘌呤核糖开关 Victor Khangulov葡萄球菌核酸酶中的内部电离残基克里斯托弗·劳（Christopher Law）与Leut的多巴胺能心理刺激剂的结合 Yorgo MODIS黄病毒包膜蛋白和复合物约翰·香克林常春发酶结构2 50S核糖体亚基的Thomas Steitz结构研究具有底物类似物由先天免疫传感器识别的Yorgo Modis微生物配体识别 Alba Guarne Cabello与Muth的Adepa研究来自枯草杆菌的天冬氨酸trancarbamoylase的Evan kantrowitz结构，甲状腺磷酸盐磷酸盐 Karin Reinisch DENN-1与Rab35复合 Matthew Cordes类似Triabin的Lipocalin 4 HIV-1 RT和RNAP的Edward Arnold结构研究 byung ha oh st_cas7 CD4和MHC II类分子DR1的Yili Li复合结构细菌信号转移蛋白复合物的liang Tang结构研究 PIOTR SLIZ的结构测定人O-GlCNAC转移酶及其与肽和抑制剂的复合物。珍妮丝·帕塔（Janice Pata）容易出错的DNA合成 Susan Buchanan使用MTMOIV的结构进行抗癌治疗的发展 Yong Xiong HIV因子和细胞相互作用蛋白伴侣 Ursula Ramirez斑岩脂蛋白合酶 Christopher Hill的RPN13/RPN2/UCH37Complexes的结构研究詹姆斯·帕森斯·帕布（James Parsons Pabb） Karen Allenβ-磷酸葡萄糖酶 Huei-jiun li 1,4-二羟基-2-萘甲基-COA合酶（MENB）与抑制剂复合乔纳森·戈德堡（Jonathan Goldberg）的结构研究 Alexei用胰岛素SOARES多晶体实验 AAA+ ATPase NTRC1的Bryan Nixon力量产生力的机理 Seth Darst细菌RNA聚合酶暂停伸长络合物 Gregory Verdine Bacillus caldotenax UVRB（DNA修复酶） Cistein蛋白酶1的Luis Brieba de Castro结构来自Entamoeba Histolictica（EHICP1） Zhaocai Zhou EGFR激酶抑制剂芭芭拉·杰拉塔纳（Barbara Gerratana Sibs） RNA诱导转录基因沉默的蛋白质复合物的Leemor Joshua-tor表征克里斯托弗·希尔（Christopher Hill）部分染色质重塑综合体杰西卡·贝尔FHBB疯狂数据收集 Hongmin Li RIP2结合蛋白 Elias Lolis的结构基础，依赖pH的人催乳素受体识别 T细胞受体的Kannan Natarajan结构，无配合，与MHC分子复合 John Shanklin Castor Bean野生型脂肪酸去饱和酶 Alba Guarne Cabello DNA不匹配维修 Mridhu指示FADL突变体的X射线结构 yili li nkp30及其配体B7-H6 Elias Lolis MIF酶促抑制和机制 Andrew Vandemark DSHRM SD2域约瑟夫·伊波利托（Joseph Ippolito Karen Allen轻链抑制剂设计 Joseph Marcotrigianoα病毒复制蛋白噬菌体N4 RNA聚合酶2和DNA复合物的Katsuhiko Murakami结构 Stevan Hubbard生长受体结合蛋白14 RAPH -RAS复合物