RAPIDATA AND OTHER THINGS

RAPIDATA 和其他东西

• 批准号: 8170686
• 负责人: ROBERT M SWEET
• 金额: $ 9.75万
• 依托单位: BROOKHAVEN SCIENCE ASSOC-BROOKHAVEN LAB
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8170686
• 关键词: Academia; American; Area; Computer Retrieval of Information on Scientific Projects Database; Computer software; Crystallography; Data; Data Collection; Educational process of instructing; Educational workshop; Enzymes; Equipment; Flowers; Funding; Goals; Grant; Hand; Hour; Industry; Institution; International; Knowledge; Learning; Left; Light; Marathon; Methods; Participant; Pharmaceutical Preparations; Process; Research; Research Personnel; Resources; Running; Science; Scientist; Source; Specimen; Structure; Students; Synchrotrons; Techniques; Time; Training; United States National Institutes of Health; Vendor; beamline; design; experience; graduate student; interest; lecturer; lectures; meetings; programs; skills

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. One of the most widely recognized courses internationally in macromolecular crystallography methods is held at the National Synchrotron Light Source (NSLS). Since 1999, students from around the world have gathered at the NSLS every spring for RapiData, a weeklong crash course organized by Sweet, Alex Soares, and Sal Sclafani, a training component of this P41 project. It's designed to introduce participants to the best and latest equipment and techniques for macromolecular x-ray crystallography. RapiData allows students to meet and learn from the leading developers of software in the crystallography field, and then to actually use NSLS beamlines to collect data. This year, 52 students attended the workshop, which was held from April 11-16. Since its creation, nearly 600 students have attended this course, and we have constant requests to add more slots. Many RapiData alumni have now blossomed into crystallography experts, and they continue to refer their less-experienced colleagues to BNL to learn the initial steps of this highly specialized area of interest. We regularly get graduate students of former RapiData students. The course began with a daylong background session taught by Sweet, meant to refresh the knowledge of crystallography fundamentals for less-experienced students. The following two days were filled with lectures and tutorials taught by scientists from BNL, industry, academia, and other national labs. Next, the students were divided into groups and guided through a marathon, 60-hour data-collection session on eight NSLS beamlines. At the same time, many tutorials were underway, run by the lecturers themselves. Nearly two-thirds of the students brought their own specimens with the goal of solving the structure of a particular enzyme, while the others observed and helped. About half a dozen structures were solved during the course, each of which could be a publishable result. During the data-collection portion of the course, the students gathered each afternoon to discuss their results and produced mini lectures about their data and scientific subject. It's always really exciting to watch the students' skills develop throughout the week. Many of them come here with little or no experience in crystallography, and they leave knowing how to obtain and process real data, as well as how to locate and fix problems as they arise. That's the advantage of having such a hands-on program. In addition to the DOE and NIH funding, a special grant was provided by the International Union for Crystallography to assist seven Latin American students in attending the course. Additional support was provided by Brookhaven Science Associates, the NSLS, and several equipment vendors and drug companies.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 在大分子晶体学方法中，国际上最广泛认可的课程之一是在国家同步加速器光源（NSLS）上。自1999年以来，来自世界各地的学生每年春季都聚集在NSLS，参加了Rapidata，这是由Sweet，Alex Soares和Sal Sclafani组织的为期一周的速成课程，这是该P41项目的培训部分。它旨在向参与者介绍大分子X射线晶体学的最新设备和技术。 Rapidata允许学生在晶体学领域的软件领先开发人员中见面并学习，然后实际使用NSLS束线来收集数据。今年，有52名学生参加了4月11日至16日举行的研讨会。 自创建以来，有近600名学生参加了此课程，我们不断要求添加更多插槽。现在，许多Rapidata校友已经进入了晶体学专家，他们继续将其经验不足的同事推荐给BNL，以了解这个高度专业的感兴趣领域的初始步骤。我们定期吸引前Rapidata学生的研究生。 该课程始于由Sweet教授的为期一天的背景会议，旨在刷新晶体学基础知识，以了解经验较弱的学生。在接下来的两天中，由BNL，Industry，Academia和其他国家实验室的科学家讲授的讲座和教程。接下来，将学生分为小组，并在八个NSLS梁线上进行了60小时的马拉松，60小时的数据收集课程。同时，许多教程正在进行中，由讲师本身经营。近三分之二的学生带来了自己的标本，目的是解决特定酶的结构，而其他学生则观察并提供了帮助。在课程中解决了大约六个结构，每个结构都可能是可发布的结果。在课程的数据收集部分中，学生每天下午都会聚集，讨论他们的结果，并就其数据和科学主题进行了微型讲座。 观看整个星期的学生的技能发展总是很令人兴奋。他们中的许多人来到这里，几乎没有晶体学经验，他们就知道如何获得和处理真实数据，以及如何在出现的问题上找到和解决问题。这就是拥有这样的动手计划的优点。 除了DOE和NIH的资金外，国际晶体学联盟提供了一项特别的赠款，以帮助七个拉丁美洲学生参加该课程。 Brookhaven Science Associates，NSLS以及几家设备供应商和制药公司提供了额外的支持。