PUBLISHED JOURNALS ARTICLES FROM THE RESOURCE WITH NO PMCID

来自没有 PMCID 的资源的已发表期刊文章

基本信息

批准号：
8170693
负责人：
ROBERT M SWEET
金额：
$ 0.25万
依托单位：
BROOKHAVEN SCIENCE ASSOC-BROOKHAVEN LAB
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-07-01 至 2011-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8170693
关键词：
ATP phosphohydrolase Acids Active Sites Adenosine Agonist Allergens Amines Anabolism Antibiotics Antibodies Antigens Antineoplastic Agents Bacteriophages Binding Bioavailable Biochemistry Bioinformatics Biotechnology Bontoxilysin Cadherins Catalytic RNA Cathepsins Cells Charge Chemicals Chemistry Chitosan Clostridium botulinum Coenzymes Complex Computer Retrieval of Information on Scientific Projects Database Coronavirus Crystallization Crystallography Cyanobacterium Cyanothece Cyclic Nucleotides Cystathionine Cystic Fibrosis Transmembrane Conductance Regulator Dependence Dictyoptera Dipeptidyl Peptidases Electrostatics Enediyne Antitumor Antibiotic Engineering Enterococcus faecalis Enterocytes Entropy Enzymes Epitopes Fab Immunoglobulins Family Feasibility Studies Ferritin Fibrinogen Fimbriae Proteins Flavin Mononucleotide Focal Adhesions Formates Fructosediphosphate Aldolase Funding Gene Expression Regulation Generations Glucosaminidase Glycopeptide Antibiotics Glycopeptides Glycoside Hydrolases Grant Guanosine Helicobacter pylori Heptoses Homologous Gene Human Hybrids Hydrolysis Imidazole Immune Influenza Institution Ions Ketones Kidney Kinetics Lesion Ligand Binding Ligand Binding Domain Lipid Binding Lyase Lysine Magnesium Membrane Metalloproteins Metals Methylmercury Compounds Methyltransferase Molecular Molecular Models Natural Killer Cells Nitrogen Fixation Nuclear Pore Periplasmic Binding Proteins Phosphoric Monoester Hydrolases Phosphotransferases Plasma Platelet Activating Factor Polymerase Potassium Channel Production Property Protein Disulfide Isomerase Proteins Pseudomonas aeruginosa Publishing RNA-Directed DNA Polymerase Reaction Receptor Protein-Tyrosine Kinases Research Research Personnel Resources Ribonucleases Ribosomes Salmonella typhi Severe Acute Respiratory Syndrome Signal Transduction Source Specificity Spectrometry Staging Structural Models Structure Structure-Activity Relationship Substrate Interaction Tail Thymidine Toxic effect Transition Elements United States National Institutes of Health Virus Yeasts Zinostatin acetoacetate decarboxylase azetidinone base condensin cupredoxin decarboxylase inhibitor design dimer electron crystallography endoplasmic reticulum glycoprotein p72 enzyme substrate glucosamine 6-phosphate handbook inhibitor/antagonist insight journal article lincosamide molecular dynamics molecular modeling multicatalytic endopeptidase complex mutant mycobacterial nitric oxide reductase novel orotidylic acid particle phosphodiesterase IV receptor receptor binding repair enzyme response tool tumor urea transporter vector vaccine voltage

ATP phosphohydrolase Acids Active Sites Adenosine Agonist Allergens Amines Anabolism Antibiotics Antibodies Antigens Antineoplastic Agents Bacteriophages Binding Bioavailable Biochemistry Bioinformatics Biotechnology Bontoxilysin Cadherins Catalytic RNA Cathepsins Cells Charge Chemicals Chemistry Chitosan Clostridium botulinum Coenzymes Complex Computer Retrieval of Information on Scientific Projects Database Coronavirus Crystallization Crystallography Cyanobacterium Cyanothece Cyclic Nucleotides Cystathionine Cystic Fibrosis Transmembrane Conductance Regulator Dependence Dictyoptera Dipeptidyl Peptidases Electrostatics Enediyne Antitumor Antibiotic Engineering Enterococcus faecalis Enterocytes Entropy Enzymes Epitopes Fab Immunoglobulins Family Feasibility Studies Ferritin Fibrinogen Fimbriae Proteins Flavin Mononucleotide Focal Adhesions Formates Fructosediphosphate Aldolase Funding Gene Expression Regulation Generations Glucosaminidase Glycopeptide Antibiotics Glycopeptides Glycoside Hydrolases Grant Guanosine Helicobacter pylori Heptoses Homologous Gene Human Hybrids Hydrolysis Imidazole Immune Influenza Institution Ions Ketones Kidney Kinetics Lesion Ligand Binding Ligand Binding Domain Lipid Binding Lyase Lysine Magnesium Membrane Metalloproteins Metals Methylmercury Compounds Methyltransferase Molecular Molecular Models Natural Killer Cells Nitrogen Fixation Nuclear Pore Periplasmic Binding Proteins Phosphoric Monoester Hydrolases Phosphotransferases Plasma Platelet Activating Factor Polymerase Potassium Channel Production Property Protein Disulfide Isomerase Proteins Pseudomonas aeruginosa Publishing RNA-Directed DNA Polymerase Reaction Receptor Protein-Tyrosine Kinases Research Research Personnel Resources Ribonucleases Ribosomes Salmonella typhi Severe Acute Respiratory Syndrome Signal Transduction Source Specificity Spectrometry Staging Structural Models Structure Structure-Activity Relationship Substrate Interaction Tail Thymidine Toxic effect Transition Elements United States National Institutes of Health Virus Yeasts Zinostatin acetoacetate decarboxylase azetidinone base condensin cupredoxin decarboxylase inhibitor design dimer electron crystallography endoplasmic reticulum glycoprotein p72 enzyme substrate glucosamine 6-phosphate handbook inhibitor/antagonist insight journal article lincosamide molecular dynamics molecular modeling multicatalytic endopeptidase complex mutant mycobacterial nitric oxide reductase novel orotidylic acid particle phosphodiesterase IV receptor receptor binding repair enzyme response tool tumor urea transporter vector vaccine voltage

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项目摘要

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Below are Published Journals articles followed by their PMIDs, for which PMCIDs have not yet been assigned: crystal structure of fab fragment of an anti-factor ix antibody 10c12 14722079 discoveryof azetidinone acids as conformationally-constrained dual ppara/- agonists 18291645 crystal structure of human factor viii implications for the formation of the factor ixa-factor viiia complex 18400180 structural basis for dsrna recognition by ns1 protein of influenza a virus 18813227 structure of a complex of the atpase seca and theprotein-translocation channel 18923516 design of biaryloxazolidinones as potent orally active antibiotics 18947996 the structure of a transcribing t7 rna polymerase in transition from initiation to elongation 18948533 generation of novel hybrid biaryloxazolidinones as promisingnew antibiotics 18951792 the structural basis of substrate recognition in an exo-b-d-glucosaminidase involved in chitosan hydrolysis 18976664 directing noble metal ion chemistry within a designed ferritin protein 18991401 a group iii periplasmic binding protein 19004000 insights into the mechanism of methylmercury degradation 19004822 structural basis for the inhibition mechanism of human cystathionine --lyase, an enzyme responsible for the production of h2s 19019829 turned on for degradation atpase-independent degradation by clpp 19038348 design, synthesis, and structure-activity relationship, molecular modeling, and nmr studies of aseries of phenyl alkyl ketones as highly potent and selective phosphodiesterase-4 inhibitors 19049349 structures of two major allergens, bla g 4 and per a 4, from cockroaches and their ige binding epitopes 19056737 an antibody loop replacement design feasibility study and a loop-swapped dimer structure 19074157 a fence-like coat for the nuclear pore membrane 19111661 its implication in faster translocation 19118561 a combinedmass spectrometry and bioinformatics approach 19125584 2-aminoimidazoles inhibitors of tgf-b receptor 1 19135364 structural studies of a bacterial condensin complex reveal atp-dependent disruption of intersubunit interactions 19135891 crystallization and preliminary x-ray crystallographic analysis of human plasma platelet activating factor acetylhydrolase 19149681 coenzyme recognition and gene regulation by a flavin mononucleotide riboswitch 19169240 structural basis for dna recognition by the human pax3 homedomain 19199574 structural and chemical basis for glucosamine 6-phosphate binding and activation of the glms ribozyme 19228039 identification and characterization of the lipid-binding property of grlr, a locus of enterocyte effacement regulator 19228114 new insights into the enzyme-substrate interaction 19245227 structure-activity relationships of orotidine-5'-monophosphate decarboxylase inhibitors as anticancer agents 19260677 structural insights into immune recognition of the severe acute respiratory syndrome coronavirus s protein receptor binding domain 19324051 structural characterization of the protein cce_0567 from cyanothece 51142, a metalloprotein associated with nitrogen fixation in the duf683 family 19336042 charge stabilization and entropy reduction of central lysine residues in fructose-bisphosphate aldolase 19354220 crystal structures of free and ligand-bound focal adhesion targeting domain of pyk2 19358827 structure and function of the glycopeptide n-methyltransferase mtfa, a tool for the biosynthesis of modified glycopeptide antibiotics 19389626 the x-ray crystal structure of the phage - tail terminator protein reveals the biologically relevant hexameric ring structure and demonstrates a conserved mechanism of tail termination among diverse long-tailed phages 19426744 structure of the noncatalytic domains and global fold of the protein disulfide isomerase erp72 19446521 orally bioavailable alkyl amines 19457666 the origin of the electrostatic perturbation in acetoacetate decarboxylase 19458715 synthesis and crystallographic analysis of 5-se-thymidine dnas 19469515 structural insights into the regulatory particle of the proteasome from methanocaldococcus jannaschii 19481527 aminopiperidine-fused imidazoles as dipeptidyl peptidase-iv inhibitors 19539471 mode of vamp substrate recognition and inhibition of clostridium botulinum neurotoxin f 19543288 combining electron crystallography and x-ray crystallography to study the mlotik1 cyclic nucleotide-regulated potassium channel 19545635 structureof natural killer cell receptor klrg1 bound to e-cadherin reveals basis for mhc-independent missing self recognition 19604491 different vaccine vectors delivering the same antigen elicit cd8+ t cell responses with distinct clonotype and epitope specificity 19620307 a bacterial persistence switch 19622872 salmonella typhi type ivb pilin (pils) and cystic fibrosis transmembrane conductance regulator interaction 19626704 structural understanding of stabilization patternsin engineered bispecific lg-like antibody molecules 19626705 impaired protofibril formation in fibrinogen -n308k is due to altered dd and "aa" interactions 19650644 the selectivity of receptor tyrosine kinase signaling is controlled by a secondary sh2 domain binding site 19665973 the structure of ef-p bound to the 70s ribosome 19696344 molecular basis of substrate promiscuity for the sam-dependent o-methyltransferase ncsb1, involved in the biosynthesis of the enediyne antitumor antibiotic neocarzinostatin 19702337 structural basis of high-fidelity dna synthesis by yeast dna polymerase delta 19718023 inhibitors selective for mycobacterial versus human proteasomes 19759536 a combined crystallographic and molecular dynamics study of cathepsin l retrobinding inhibitors 19761244 different triggers but related mechanisms 19769984 structural studies on cytosolic domain of magnesium transporter mgte from enterococcus faecalis 19787770 crystal structure of a bacterial homologue of the kidney urea transporter 19865084 characterization of a ras mutant with identical gdp- and gtp-bound structures 19883123 rationally tuning the reduction potential of a single cupredoxin beyond the natural range 19890331 structural characterization of novel pseudomonas aeruginosa type iv pilins 19895819 evidence of kinetic controlof ligand binding and staged product release in mura (enolpyruvyl udp-glcnac synthase)-catalyzed reactions 19899805 a new activity of anti-hiv and anti-tumor protein gap31 dna adenosine glycosidase - structural and modeling insight into its functions 19900411 physical determinants of strong voltage sensitivity of k+ channel block 19915587 a structural basis for the reduced toxicity of dinophysistoxin-2 19916524 rational design of a structural and functional nitric oxide reductase 19940850 helicobacter pylori caga inhibits par1-mark family kinases by mimicking host substrates 19966800 structure of hiv-1 reverse transcriptase with the inhibitor b-thujaplicinol bound at the rnase h active site 20004166 structure and mechanism of the lincosamide antibiotic adenylyltransferase linb 20004168 encounter and extrusion of an intrahelical lesion by a dna repair enzyme 20010681 structure and mechanism of a pentameric formate channel 20010838 synthesis and crystal structure of 2--se-modified guanosine containing dna 20047333 structural and kinetic characterization of the lps biosynthetic enzyme d-alpha,beta-d-heptose-1,7-bisphosphate phosphatase (gmhb) fromescherichia coli 20050699 handbook on cyanobacteria biochemistry, biotechnology and applications, pp 233-57 ha1,2 hypersatellites of 3d transition metals and their photoexcitation energy dependence shell diagram and hypersatellite spectra of 4d transition elements phd thesis synthesis and crystal structure study of 2--se-adenosine-derivatized dna

该副本是利用众多研究子项目之一由NIH/NCRR资助的中心赠款提供的资源。子弹和调查员（PI）可能已经从其他NIH来源获得了主要资金，因此可以在其他清晰的条目中代表。列出的机构是对于中心，这不一定是调查员的机构。以下是发表的期刊文章，然后是其PMID，尚未分配PMCID：抗因子IX抗体的Fab碎片的晶体结构10C12 14722079 偶氮酮酸的发现作为构象约束的双PPARA/ - 激动剂18291645 人类因子VIII对因子IXA因子VIIIA复合物的形成的晶体结构18400180 dsRNA识别的结构基础是流感病毒的NS1蛋白18813227 ATPase Seca和蛋白质转换通道的结构18923516 双氧唑烷酮作为有效的口服活性抗生素的设计18947996 从启动到伸长率的过渡过程中，转录T7 RNA聚合酶的结构18948533 新型杂交双氧唑烷酮作为有希望的新抗生素18951792 在参与壳聚糖水解的Exo-B-D-葡萄糖胺酶中底物识别的结构基础1897664 在设计的铁蛋白蛋白18991401中指导贵金属离子化学 III组周质结合蛋白19004000 对甲基汞降解机理的见解，19004822 抑制人胱胱氨而生的抑制机制的结构基础，lyase，一种负责H2S生产19019829的酶打开CLPP 19038348的非依赖ATPase降解的降解设计，合成和结构活性关系，分子建模和NMR研究苯基烷基酮的ASERIES作为高效和选择性磷酸二酯酶4抑制剂19049349 来自蟑螂及其IgE结合表位的两个主要过敏原的结构，bla g 4和per a 4 19056737 抗体回路替换设计可行性研究和循环折叠二聚体结构19074157 核孔膜的围栏状涂层19111661 它在更快的易位19118561中的含义组合质谱和生物信息学方法19125584 TGF-B受体的2-氨基咪唑抑制剂19135364 细菌冷凝蛋白复合物的结构研究揭示了ATP依赖性间隔相互作用的破坏19135891 人血浆血小板激活因子乙酰水合酶19149681的结晶和初步X射线晶体学分析黄素单核苷酸核糖开关19169240辅酶识别和基因调节人类PAX3 Homedomain 19199574识别DNA识别的结构基础葡萄糖6-磷酸结合和GLMS核酶激活的结构和化学基础19228039 GRLR的脂质结合特性的识别和表征，GRLR，肠of依的位点19228114 对酶 - 基底互动的新见解19245227 Orotidine-5'-单磷酸脱羧酶抑制剂作为抗癌剂的结构活性关系19260677 对严重急性呼吸综合征冠状病毒蛋白受体结合结构域的免疫识别的结构见解19324051 氰基51142的蛋白质CCE_0567的结构表征，一种与DUF683家族中固氮相关的金属蛋白19336042 果糖 - 双磷酸醛酶中中央赖氨酸残基的电荷稳定和熵减少19354220 PYK2 19358827的自由和配体结合焦点粘附域的晶体结构糖肽N-甲基转移酶MTFA的结构和功能，这是修饰糖肽抗生素的生物合成的工具19389626 噬菌体尾终端蛋白的X射线晶体结构揭示了与生物学相关的六聚体环结构，并在不同的长尾噬菌体中证明了尾终止的保守机制19426744 蛋白质二硫化物异构酶ERP72 19446521的非催化结构域的结构和全局折叠的结构口服生物利用烷基胺19457666 乙酸脱羧酶中静电扰动的起源19458715 5-SE-甲酰胺DNAS的合成和晶体学分析19469515 从Jannaschii 19481527对蛋白酶体调节粒子的结构见解作为二肽基肽酶-IV抑制剂19539471的氨基酸氨基丁烷融合的咪唑鞋面底物识别和抑制肉毒梭菌神经毒素F 19543288的抑制模式结合电子晶体学和X射线晶体学以研究MLOTIK1环状核苷酸调节的钾通道19545635 与电子钙粘蛋白结合的天然杀手细胞受体KLRG1的结构揭示了独立于MHC的自识别的基础19604491 提供相同抗原的不同疫苗向量引起了CD8+ T细胞反应，具有不同的clonotype和Eperpope特异性19620307 细菌持久性开关19622872 沙门氏菌Typhi型IVB PILIN（PILS）和囊性纤维化跨膜电导调节剂相互作用19626704 对稳定模式的结构理解，工程双特异性LG样抗体分子19626705 纤维蛋白原-N308K中原纤维形成受损是由于DD改变和“ AA”相互作用19650644 受体酪氨酸激酶信号的选择性由次级SH2域结合位点控制19665973 EF-P结构与70年代核糖体结合19696344 SAM依赖性O-甲基转移酶NCSB1的底物滥交的分子基础，参与ENEDIYNE抗肿瘤抗生素Neocarzinostatin 19702337的生物合成酵母DNA聚合酶Delta 19718023的高保真DNA合成的结构基础分枝杆菌与人蛋白酶体的抑制剂选择性19759536 组织蛋白酶l反刺抑制剂的结合晶体学和分子动力学研究19761244 不同的触发器但相关机制19769984 镁转运蛋白MGTE的胞质结构域的结构研究，粪肠球菌19787770 肾脏尿素转运蛋白的细菌同源物的晶体结构19865084 具有相同GDP和GTP结构结构的RAS突变体的表征19883123 理性地调整自然范围以外的单个杯状毒素的减少潜力19890331 新型假单胞菌IV Pilins 19895819的结构表征在Mura（Enolpyruvyl UDP-GLCNAC合酶）中的配体结合和分期产品释放的动力学控制的证据19899805 抗HIV和抗肿瘤蛋白GAP31 DNA腺苷糖苷酶的新活性 - 结构和建模洞察其功能19900411 K+通道块强电压灵敏度的物理决定因素19915587 降低Dinophysistoxin-2 19916524毒性降低的结构基础结构和功能一氧化氮还原酶19940850的合理设计幽门螺杆菌幽门螺杆菌通过模仿宿主底物19966800抑制par1-ramk族激酶 HIV-1逆转录酶的结构与抑制剂B- thujaplinol结合在RNase H活性位点20004166 Lincosamide抗生素腺苷转移酶Linb的结构和机制Linb 20004168 通过DNA修复酶20010681遇到和挤出了内部病变五聚体构造通道20010838的结构和机制 2-se修饰的鸟苷的合成和晶体结构含有DNA 20047333 LPS生物合成酶D-Alpha，β-D-肽1,7-双磷酸磷酸酶（GMHB）的结构和动力学表征关于蓝细菌生物化学，生物技术和应用的手册，第233-57页 HA1,2 3D过渡金属的高卫星及其光激发能量依赖性 4D过渡元件的壳图和卫生部光谱博士学位论文 2-se腺苷衍生的DNA的合成和晶体结构研究