NMR User Program at NMRFAM

NMRFAM 的 NMR 用户计划

基本信息

批准号：
10192904
负责人：
Samuel E Butcher
金额：
$ 96.66万
依托单位：
UNIVERSITY OF WISCONSIN-MADISON
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-09-01 至 2026-05-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10192904
关键词：
Address Adopted Advisory Committees Area Automation Biological Biomedical Research Biophysics Calibration Capital Cell Nucleus Communities Complex Computer software Consult Cryoelectron Microscopy Custom Data Data Analyses Data Collection Data Security Detection Development Doctor of Philosophy Educational workshop Emerging Technologies Ensure FAIR principles Goals Helium Home Human Resources Hybrids Individual Infrastructure Institution Isotopes Knowledge Ligands Liquid substance Magic Magnetic Resonance Maintenance Membrane Proteins Methods Mission Molecular Weight Monoclonal Antibody R24 NMR Spectroscopy National Center for Research Resources National Institute of General Medical Sciences Natural Products Nucleic Acids Performance Pharmaceutical Preparations Phase Physiologic pulse Procedures Proteins Protocols documentation Quality Control Recovery Recycling Reproducibility Research Support Resource Development Resources Sampling Schedule Scientist Services Site Standardization Structure Surveys System Technology Testing Time Training Tube United States National Institutes of Health Work base collaborative approach community engagement computerized data processing cryogenics cyber security data quality data sharing design experience experimental study improved instrument instrumentation interest knowledge base metabolomics next generation operation outreach programs protein structure recruit repaired screening solid state nuclear magnetic resonance structural biology tool training opportunity

Address Adopted Advisory Committees Area Automation Biological Biomedical Research Biophysics Calibration Capital Cell Nucleus Communities Complex Computer software Consult Cryoelectron Microscopy Custom Data Data Analyses Data Collection Data Security Detection Development Doctor of Philosophy Educational workshop Emerging Technologies Ensure FAIR principles Goals Helium Home Human Resources Hybrids Individual Infrastructure Institution Isotopes Knowledge Ligands Liquid substance Magic Magnetic Resonance Maintenance Membrane Proteins Methods Mission Molecular Weight Monoclonal Antibody R24 NMR Spectroscopy National Center for Research Resources National Institute of General Medical Sciences Natural Products Nucleic Acids Performance Pharmaceutical Preparations Phase Physiologic pulse Procedures Proteins Protocols documentation Quality Control Recovery Recycling Reproducibility Research Support Resource Development Resources Sampling Schedule Scientist Services Site Standardization Structure Surveys System Technology Testing Time Training Tube United States National Institutes of Health Work base collaborative approach community engagement computerized data processing cryogenics cyber security data quality data sharing design experience experimental study improved instrument instrumentation interest knowledge base metabolomics next generation operation outreach programs protein structure recruit repaired screening solid state nuclear magnetic resonance structural biology tool training opportunity

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项目摘要

PROJECT SUMMARY The National Magnetic Resonance Facility at Madison (NMRFAM) provides timely and reliable access to mature NMR technology for application to a wide array of biomedical research questions. NMRFAM has staff with decades of experience in facility operation and maintenance, a dozen high-field NMR spectrometers equipped with state-of-the-art probe technology, and facility infrastructure (ample space, uninterrupted power systems, environmental control, helium recovery) second to none, and NMRFAM has been at the forefront of standardization, data stewardship through FAIR (findable, accessible, interoperable and reusable) data principles and dissemination of best practices to the community. Support through the NIGMS R24 program of NMRFAM through the R24 mechanism at NIGMS would support broad access to this exceptional resource in Madison to leverage economies of scale, including stable and efficient operation that maximizes data quality and minimizes instrument down time, facilitating many types of experiments that scientists are not able to perform at their home institutions. Furthermore, the proposed next generation user program improves the rigor and reproducibility of NMR data collection through instrument quality control, standard operating procedures, new sample standards for microcrystalline proteins and nucleic acids, membrane proteins and fibrils, including development of approaches for dynamics and function as well as structure. NMRFAM staff provide an exceptional level of service tailored to the needs of individual users and projects, serving arguably the broadest user base of any NMR facility in the US. NMRFAM actively seeks to support diverse users through outreach and user training opportunities (workshops, video tutorials, protocols) to teach users how to understand and analyze their NMR data. NMRFAM has a goal of providing users more than spectra, and the facility provides staff support and automation tools to return deliverables: i.e., scientific knowledge not only data. The NMRFAM mission lowers barriers to NMR and maximizes the impact of the facility when users can successfully apply the NMR data to answer their biological question of interest. NMRFAM has built a reputation as a top-level facility for external users and this project will maintain affordable access to NMRFAM. NMRFAM staff will regularly evaluate performance criteria and consult with the external advisory committee and facility users so that the facility continues to remain at the cutting edge and meet the needs of its user base.

项目摘要麦迪逊（NMRFAM）的国家磁共振设施提供及时可靠的访问 NMR技术用于应用多种生物医学研究问题。 NMRFAM有工作人员数十年的设施操作和维护经验，配备了十几个高场NMR光谱仪借助最先进的探测技术和设施基础架构（足够的空间，不间断的电源系统，环境控制，氦恢复）首屈一指，NMRFAM一直处于标准化，通过公平（可访问，可互操作和可重复使用的）数据管理数据将最佳实践的原则和传播给社区。通过NIGMS R24计划的支持 NMRFAM通过NIGMS的R24机制将支持对此类特殊资源的广泛访问麦迪逊（Madison）利用规模经济，包括稳定有效的操作，可最大化数据质量最大程度地减少仪器的停机时间，促进科学家无法执行的许多类型的实验他们的家庭机构。此外，拟议的下一代用户计划改善了严格和通过仪器质量控制，标准操作程序，新的NMR数据收集NMR数据的可重复性微晶蛋白和核酸，膜蛋白和原纤维的样品标准标准，包括开发动态和功能以及结构的方法。 NMRFAM员工提供根据个人用户和项目的需求量量身定制的卓越服务水平，可以说是最广泛的服务美国任何NMR设施的用户群。 NMRFAM积极寻求通过外展支持多样的用户以及用户培训机会（研讨会，视频教程，协议），以教用户如何理解和分析其NMR数据。 NMRFAM的目标是为用户提供更多的光谱，该设施提供了员工支持和自动化工具以返回可交付成果：即科学知识不仅数据。 NMRFAM 任务降低了NMR的障碍，并在用户可以成功应用该设施时最大化设施的影响 NMR数据回答他们的生物学问题。 NMRFAM已建立了顶级设施的声誉对于外部用户，该项目将维持对NMRFAM的负担得起的访问。 NMRFAM员工会定期评估绩效标准并咨询外部咨询委员会和设施使用者设施继续保持在最前沿，并满足其用户群的需求。