NEURAL CORRELATES OF EXECUTIVE FUNCTION AND EMOTION IN ADOLESCENCE

青少年执行功能和情绪的神经相关性

• 批准号: 8362825
• 负责人: KATHLEEN M THOMAS
• 金额: $ 0.38万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-06-01 至 2012-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8362825
• 关键词: Adolescence; Adult; Affective; Age; Behavioral; Boxing; Brain; Data; Emotions; Equipment; Functional Imaging; Funding; Grant; Hour; Image; International; Letters; Location; Magnetic Resonance Imaging; NMR Spectroscopy; National Center for Research Resources; Participant; Positioning Attribute; Principal Investigator; Reaction Time; Research; Research Infrastructure; Resolution; Resources; Running; Scanning; Series; Slice; Source; System; Teenagers; United States National Institutes of Health; computer center; cost; executive function; relating to nervous system; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Participants will be 14 adults between the ages of 20-22 years and 16 teens between the ages of 13-14 years. The scanning session will begin with a sagittal scout for purposes of prescribing subsequent images. Sagittal T1 MPRAGE images will be aquired for coregistration of functional images. Whole brain EPI BOLD images will be acquired in three runs while subjects perform the behavioral task below. An EPI fieldmap will be acquired at the same resolution and slice locations to allow for offline correction of field inhomogeneities. The behavioral combines a go/nogo task with emotionally arousing background images selected from the International Affective Picture System. In this task, letters are presented sequentially in a small box at the center of the computer screen. Subjects are asked to respond as quickly as possible with a button press to every one of a series of letters except for a specific target: an 'X'. The Xs appear on 25% of trials such that participants acquire a prepotent tendency to press and need to actively inhibit their response during nogo trials. The behavioral task consists of three runs of twelve blocks. Responses (press or no press) and reaction times will be recorded using an MRI compatible button box. We anticipate the entire session taking one hour per subject. This estimate includes 15 minutes for equipment setup and positioning of the participant, 11 minutes of structural scanning, 30 minutes of functional scanning and 10 minutes of clean-up and data transfer.

该副本是利用资源的众多研究子项目之一 由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持 而且，副投影的主要研究员可能是其他来源提供的 包括其他NIH来源。 列出的总费用可能 代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。 参与者将是20-22岁的14岁成年人，在13-14岁之间的青少年中将是16名成年人。 扫描会话将从矢状侦察兵开始，以开出后续图像。矢状T1 mprage图像将用于功能图像的核心。全脑EPI BOLD图像将在三次跑步中获取，而受试者在下面执行行为任务。 EPI现场图将在相同的分辨率和切片位置获取，以允许对现场不均匀性的离线校正。 该行为结合了GO/Nogo任务与从国际情感图片系统中选择的情感唤醒背景图像。在此任务中，字母在计算机屏幕中心的一个小盒子中顺序显示。除了特定目标外，要求受试者按按钮按下一系列字母中的每一个：AN“ X”，以尽快响应。 XS出现在25％的试验中，因此参与者获得了迫切能力的趋势，需要在Nogo试验中积极抑制其反应。行为任务由三个块组成。将使用MRI兼容按钮框记录响应（按下或不按下）和反应时间。 我们预计整个课程都需要一个小时。该估计值包括15分钟的设备设置和参与者的定位，11分钟的结构扫描，30分钟的功能扫描以及10分钟的清理和数据传输。