Neurodevelopment of exploration and alcohol problems in adolescence

青春期探索和酒精问题的神经发育

基本信息

批准号：
10628964
负责人：
Jeremy P Hogeveen
金额：
$ 59.39万
依托单位：
UNIVERSITY OF NEW MEXICO
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-05-05 至 2028-03-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10628964
关键词：
Acceleration Address Adolescence Adolescent Adolescent and Young Adult Adult Affective Alcohol abuse Alcohol consumption Alcohols Amygdaloid structure Automobile Driving Behavior Behavioral Mechanisms Biological Assay Brain Cellular Phone Chronic Clinical Cognitive Computer Models Corpus striatum structure Cross-Sectional Studies Curiosities Data Decision Making Decision Trees Development Dimensions Dissociation Environment Exploratory Behavior Food Friends Functional Magnetic Resonance Imaging Future Goals Growth Health Individual Intervention Laboratories Learning Life Link Lobule Longitudinal Studies Measurement Measures Methods Modeling Motivation Neurons Neurosciences Parents Participant Personality Persons Phenotype Positioning Attribute Prefrontal Cortex Punishment Randomized Research Research Personnel Rewards Risk Science Sensory Severities Shapes Stimulus Testing Visit Work Youth addiction adolescent alcohol abuse age related alcohol monitoring alcohol research alcohol risk alcohol use disorder chronic alcohol ingestion design diaries disorder risk drinking early drinking experience experimental study improved in vivo innovation neural neural circuit neurodevelopment neuroimaging neuromechanism novel peer predictive test preference preventable death preventive intervention programs random forest recruit reduced alcohol use resilience response skills social social influence societal costs tool trait underage drinking young adult

项目摘要

PROJECT SUMMARY Exploring novel and unfamiliar foods, friend groups, and activities during adolescence critically shapes our preferences and personalities in adulthood. Conversely, for adolescents who engage in underage drinking, such novelty-seeking can be maladaptive and lead to the development of chronic alcohol use problems. Cross- sectional studies suggest that individuals become more strategic in their use of goal-directed exploration to optimize choice during the transition from adolescence to young adulthood. The core hypothesis of the proposed study is that the maturation of directed exploration is blunted or lagged in adolescents who experiment with alcohol and go on to develop increased alcohol use problems. Specifically, we will conduct an accelerated longitudinal fMRI study of N=135 participants (recruited at 13-21 years), merging clinical assays of alcohol use severity, computational modeling of novelty-driven exploration across multiple tasks, model-based decomposition of fMRI data at three longitudinal timepoints, and smartphone-based daily diary assessments to probe alcohol- and novelty-related decision making in vivo outside of the laboratory. In Aim 1 we will test the hypothesis that the normative maturation of novelty-driven exploration—i.e., expansion of strategic, goal- directed exploration to optimize choice—will be negatively modulated by increased alcohol use severity. Further, we will use longitudinal model-based fMRI to determine whether this expansion of directed exploration is driven by age-related increases in neural encoding of the latent value of exploring new options in frontoparietal (i.e., frontopolar cortex, dorsolateral prefrontal cortex, and intraparietal lobule) and motivational (i.e., striatum, amygdala, and orbitofrontal cortex) neural circuits. In Aim 2 we will contrast novelty-driven exploration to maximize gains versus minimize losses, hypothesizing that the presence of potential punishments should decrease exploratory behavior as individuals are motivated to avoid potential losses. Differentiation between reward- and punishment-evoked neural responses is blunted in adolescents with alcohol use problems, therefore we hypothesize that differential gating of novelty exploration across gain versus loss contexts will be diminished in adolescents with higher alcohol use severity. Lastly, in Aim 3 we will use daily diary prompts delivered via smartphone to determine the ecological relevance of our laboratory- based decision making assays for predicting real-world alcohol- and novelty-directed behaviors. This triangulation of computational phenotyping, neuroimaging, and ecologically-situated assessments has not been performed in existing studies, and could identify a new novelty-driven exploration dimension to be considered in future iterations of the Addictions Neuroclinical Assessment framework. In line with the Katz Early Stage Investigator mechanism—this computational developmental science approach will represent an innovative advance that will launch the PI in a new research direction: leveraging his skills and expertise in adolescent neuroimaging to focus on the development of decision making neurocircuitry and risk for alcohol use problems in adolescence.

项目概要在青春期探索新奇和不熟悉的食物、朋友群体和活动，批判性地塑造我们的性格未成年人饮酒的青少年在线下的偏好和性格，这种寻求新奇的行为可能会导致适应不良，并导致慢性酒精使用问题的发展。分段研究表明，个人在使用目标导向的探索来实现目标时变得更具战略性。从青春期到青年期过渡期间的优化选择。拟议的研究表明，在以下情况的青少年中，定向探索的成熟度会减弱或滞后具体而言，我们将进行酒精实验并继续研究酒精使用增加的问题。对 N=135 名参与者（在 13-21 岁招募）的加速纵向 fMRI 研究，合并了酒精使用严重程度、跨多个任务的新颖性驱动探索的计算模型、基于模型在三个纵向时间点分解功能磁共振成像数据，以及基于智能手机的每日日记评估在实验室外探索酒精和新颖性相关的体内决策在目标 1 中，我们将测试假设新颖性驱动的探索的规范成熟——即战略、目标的扩展—— 旨在优化选择的定向探索——将因饮酒严重程度的增加而受到负面影响。此外，我们将使用基于纵向模型的功能磁共振成像来确定定向探索的这种扩展是否是由与年龄相关的神经编码增加驱动的，探索新选择的潜在价值额顶叶（即额极皮层、背外侧前额叶皮层和顶内小叶）和动机在目标 2 中，我们将对比新奇驱动的神经回路（即纹状体、杏仁核和眶额皮层）。探索最大化收益而不是最小化收益，假设存在潜在的惩罚应该减少探索行为，因为个人有动力避免潜在的损失。在患有以下疾病的青少年中，奖赏和惩罚引起的神经反应之间的区分变得迟钝酒精使用问题，因此我们勇敢地对不同增益的新奇探索进行不同的门控最后，在目标 3 中，酒精使用严重程度较高的青少年的损失情境将会减少。使用通过智能手机提供的每日日记提示来确定我们实验室的生态相关性- 基于决策分析来预测现实世界中的酒精和新奇行为。计算表型分析、神经影像学和生态状况评估的三角测量尚未得到证实在现有研究中进行，并且可以确定要考虑的新的新颖性驱动的探索维度成瘾神经临床评估框架的未来迭代符合卡茨早期阶段。研究者机制——这种计算发展科学方法将代表一种创新该进展将使 PI 进入一个新的研究方向：利用他在青少年领域的技能和专业知识神经影像学重点关注决策神经回路的发展和饮酒问题的风险在青春期。