Neurodevelopment of exploration and alcohol problems in adolescence

青春期探索和酒精问题的神经发育

• 批准号: 10628964
• 负责人: Jeremy P Hogeveen
• 金额: $ 59.39万
• 依托单位: UNIVERSITY OF NEW MEXICO
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-05-05 至 2028-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10628964
• 关键词: Acceleration; Address; Adolescence; Adolescent; Adolescent and Young Adult; Adult; Affective; Alcohol abuse; Alcohol consumption; Alcohols; Amygdaloid structure; Automobile Driving; Behavior; Behavioral Mechanisms; Biological Assay; Brain; Cellular Phone; Chronic; Clinical; Cognitive; Computer Models; Corpus striatum structure; Cross-Sectional Studies; Curiosities; Data; Decision Making; Decision Trees; Development; Dimensions; Dissociation; Environment; Exploratory Behavior; Food; Friends; Functional Magnetic Resonance Imaging; Future; Goals; Growth; Health; Individual; Intervention; Laboratories; Learning; Life; Link; Lobule; Longitudinal Studies; Measurement; Measures; Methods; Modeling; Motivation; Neurons; Neurosciences; Parents; Participant; Personality; Persons; Phenotype; Positioning Attribute; Prefrontal Cortex; Punishment; Randomized; Research; Research Personnel; Rewards; Risk; Science; Sensory; Severities; Shapes; Stimulus; Testing; Visit; Work; Youth; addiction; adolescent alcohol abuse; age related; alcohol monitoring; alcohol research; alcohol risk; alcohol use disorder; chronic alcohol ingestion; design; diaries; disorder risk; drinking; early drinking; experience; experimental study; improved; in vivo; innovation; neural; neural circuit; neurodevelopment; neuroimaging; neuromechanism; novel; peer; predictive test; preference; preventable death; preventive intervention; programs; random forest; recruit; reduced alcohol use; resilience; response; skills; social; social influence; societal costs; tool; trait; underage drinking; young adult

PROJECT SUMMARY Exploring novel and unfamiliar foods, friend groups, and activities during adolescence critically shapes our preferences and personalities in adulthood. Conversely, for adolescents who engage in underage drinking, such novelty-seeking can be maladaptive and lead to the development of chronic alcohol use problems. Cross- sectional studies suggest that individuals become more strategic in their use of goal-directed exploration to optimize choice during the transition from adolescence to young adulthood. The core hypothesis of the proposed study is that the maturation of directed exploration is blunted or lagged in adolescents who experiment with alcohol and go on to develop increased alcohol use problems. Specifically, we will conduct an accelerated longitudinal fMRI study of N=135 participants (recruited at 13-21 years), merging clinical assays of alcohol use severity, computational modeling of novelty-driven exploration across multiple tasks, model-based decomposition of fMRI data at three longitudinal timepoints, and smartphone-based daily diary assessments to probe alcohol- and novelty-related decision making in vivo outside of the laboratory. In Aim 1 we will test the hypothesis that the normative maturation of novelty-driven exploration—i.e., expansion of strategic, goal- directed exploration to optimize choice—will be negatively modulated by increased alcohol use severity. Further, we will use longitudinal model-based fMRI to determine whether this expansion of directed exploration is driven by age-related increases in neural encoding of the latent value of exploring new options in frontoparietal (i.e., frontopolar cortex, dorsolateral prefrontal cortex, and intraparietal lobule) and motivational (i.e., striatum, amygdala, and orbitofrontal cortex) neural circuits. In Aim 2 we will contrast novelty-driven exploration to maximize gains versus minimize losses, hypothesizing that the presence of potential punishments should decrease exploratory behavior as individuals are motivated to avoid potential losses. Differentiation between reward- and punishment-evoked neural responses is blunted in adolescents with alcohol use problems, therefore we hypothesize that differential gating of novelty exploration across gain versus loss contexts will be diminished in adolescents with higher alcohol use severity. Lastly, in Aim 3 we will use daily diary prompts delivered via smartphone to determine the ecological relevance of our laboratory- based decision making assays for predicting real-world alcohol- and novelty-directed behaviors. This triangulation of computational phenotyping, neuroimaging, and ecologically-situated assessments has not been performed in existing studies, and could identify a new novelty-driven exploration dimension to be considered in future iterations of the Addictions Neuroclinical Assessment framework. In line with the Katz Early Stage Investigator mechanism—this computational developmental science approach will represent an innovative advance that will launch the PI in a new research direction: leveraging his skills and expertise in adolescent neuroimaging to focus on the development of decision making neurocircuitry and risk for alcohol use problems in adolescence.

项目摘要 探索青少年少数的小说和陌生食品，朋友团体和活动批判性地塑造了我们 成年后的偏好和个性。相反，对于从事未成年饮酒的青少年 这种新颖性寻求适应不良，并导致慢性酒精使用问题的发展。叉- 部分研究表明，个人在使用目标定向探索方面变得更具战略性 优化从青少年到成年的过渡期间的选择。核心假设 拟议的研究是，在青少年中，定向勘探的成熟被钝化或滞后 尝试酒精并继续发展增加酒精使用问题。具体来说，我们将进行 n = 135名参与者的加速纵向fMRI研究（在13-21岁时招募），合并的临床评估 酒精使用严重程度，跨多个任务的新颖性探索的计算建模，基于模型 fMRI数据在三个纵向时间点的分解，以及基于智能手机的日记评估 探测实验室以外的体内与酒精和新颖相关的决策。在AIM 1中，我们将测试 假设新颖驱动探索的正常成熟 - 即，战略性，目标的扩展 定向探索以优化选择 - 将因饮酒严重程度增加而对其进行负面调节。 此外，我们将使用基于纵向模型的fMRI来确定是否有针对性探索的扩展 由年龄相关的驱动于与年龄相关的增加的神经编码的探索新选项的潜在价值的神经编码。 额叶（即额骨皮层，背侧前额叶皮层和室内小叶）和动机 （即纹状体，杏仁核和眶额皮层）神经回路。在AIM 2中，我们将与新颖性驱动 探索以最大化收益与最小化损失，假设存在潜力 惩罚应降低探索性行为，因为个人被激励避免潜在的损失。 奖励和惩罚诱发的神经反应之间的区别在于青少年 酒精使用问题，因此我们假设跨增益的新颖性探索差异 在饮酒严重程度较高的青少年中，损失环境将减少。最后，在目标3中，我们将 使用通过智能手机提供的日记提示来确定我们实验室的生态相关性 - 基于预测现实世界中酒精和新颖性行为的基于决策测定法。这 计算表型，神经影像学和生态定位评估的三角剖分尚未 在现有研究中进行，可以确定以新的新颖驱动探索维度 在未来的成瘾迭代中，神经临床评估框架。与卡茨早期舞台一致 研究者机制 - 这种计算发展科学方法将代表一种创新的 提前将朝着新的研究方向推出PI：利用他在青少年的技能和专业知识 神经影像专注于制定神经通路和酒精使用问题的风险的发展 在青春期。