NEUROCOGNITIVE OUTCOMES OF INFANTS OF DIABETIC MOTHERS

糖尿病母亲的婴儿的神经认知结果

• 批准号: 7951694
• 负责人: KATHLEEN M THOMAS
• 金额: $ 0.07万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-12-01 至 2009-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7951694
• 关键词: Address; Anatomy; Area; Behavioral; Child; Clinical Research; Computer Retrieval of Information on Scientific Projects Database; Corpus striatum structure; Environment; Functional Magnetic Resonance Imaging; Funding; Goals; Grant; Hippocampus (Brain); Institution; Iron; Magnetic Resonance Imaging; Memory; Metabolic; Metabolism; Nature; Neurocognitive; Neuropsychology; Outcome; Performance; Population Study; Pregnancy; Public Health; Research; Research Personnel; Resources; Sampling; School-Age Population; Schools; Source; United States National Institutes of Health; cognitive function; cohort; elementary school; fetal; infant of diabetic mother; maternal diabetes; neural circuit; prenatal; white matter

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The goal of this current proposal is to continue to study our cohort of children as they enter the elementary school years. We are focusing our efforts specifically on three areas. First, we intend to document more specifically the nature of the functional and structural deficits observed to date: thus, what types of memory are impaired, and how extensive is the damage to the hippocampus? Second, we seek to determine whether deficits in other cognitive functions emerge as our study populations makes the transition to school age; specifically, do we observe deficits in striatal or prefrontal functions? And, is there an association between such deficits and school performance? Finally, we wish to characterize further what neural circuits have been compromised by the adverse fetal environment that is common among IDMs; specifically, confirm our prediction of hippocampal damage (as inferred from reduced hippocampal volume and/or metabolism) and/or whether we observe damage to striatum, and/or whether we observe reductions in white matter due to prenatal iron deficiency. We will address these questions by conducting detailed electrophysiological (ERPs), metabolic (fMRI), anatomic (MRI), and behavioral (neuropsychologic) studies on our current samples of IDMs and comparison children. Given that approximately 10% of all pregnancies are complicated by maternal diabetes, the current project has important implications for public health.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 当前建议的目的是继续研究我们进入小学年代的儿童队列。我们将精力集中在三个领域。 首先，我们打算更具体地记录到迄今为止观察到的功能和结构缺陷的性质：因此，哪种类型的记忆受损，以及海马的损害有多广泛？ 其次，我们试图确定其他认知功能的缺陷是否出现，因为我们的研究人群将过渡到学龄。具体来说，我们是否观察到纹状体或前额叶功能的缺陷？ 而且，这种赤字与学校表现之间是否存在关联？ 最后，我们希望进一步表征哪些神经回路已被IDM中常见的不良胎儿环境所妥协。具体而言，确认我们对海马损伤的预测（根据海马体积减少和/或代谢所推断）和/或我们是否观察到纹状体的损害，以及/或我们是否观察到由于产前铁的缺陷而导致的白质减少。 我们将通过对我们目前的IDM和比较儿童样本进行详细的电生理（ERP），代谢（FMRI），解剖（MRI）和行为（神经心理学）研究来解决这些问题。 鉴于所有妊娠中大约有10％的孕妇糖尿病变得复杂，因此目前的项目对公共卫生具有重要影响。