IMPACT OF BDNF GENOTYPE AND EARLY LIFE STRESS ON LEARNING AND BRAIN DEVELOPMENT

BDNF 基因型和早期生活压力对学习和大脑发育的影响

• 批准号: 8362824
• 负责人: KATHLEEN M THOMAS
• 金额: $ 0.38万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-06-01 至 2012-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8362824
• 关键词: 14 year old; 18 year old; Address; Adoption; Age; Amygdaloid structure; BDNF gene; Brain; Brain-Derived Neurotrophic Factor; Caring; Cues; Development; Dose; Funding; Genes; Genetic Polymorphism; Genotype; Goals; Grant; Hippocampus (Brain); Home environment; Hospitals; Human; Institutes; Institution; Knock-in Mouse; Learning; Life; Life Stress; Magnetic Resonance Imaging; Modeling; Mus; NMR Spectroscopy; National Center for Research Resources; National Institute of Mental Health; New York; Orphanages; Participant; Prefrontal Cortex; Principal Investigator; Research; Research Infrastructure; Resources; Source; Stress; Structure; System; Testing; Time; United States National Institutes of Health; adopted child; behavior measurement; cognitive control; cost; experience; learning extinction; neurodevelopment; postnatal

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Stress has been shown to alter the development of neural systems involved in learning (particularly contextual, cued, and extinction learning) and cognitive control. Emerging evidence in the human and mouse suggests that stressful experiences result in region-specific alterations in BDNF levels. The overarching goal of this project is to test the hypothesis that the Val66Met polymorphism in the BDNF gene will moderate the effects of early life stress (in the form of institutional/orphanage rearing) on the structure and function of the hippocampus, amygdala and ventromedial prefrontal cortex (including orbital prefrontal cortex). Participants will be 12-14 year old children adopted internationally between the ages of 4 months and 5 years after having lived for 75% or more of their pre-adoption lives in institutions (hospitals, orphanage). We will test the hypothesis that the BDNF Val66Met polymorphism will moderate the impact of early life stress (dose/duration of institutional care) on structure and function of these regions. We will also examine whether these effects are diminished with time in the adoptive home. This project is part of an NIMH Center grant that includes additional projects addressing the impact of BDNF genotype on learning and cognitive control in typical development from 8-18 years of age (Sackler Institute, New York) and a knock-in gene model of the Val66Met polymorphism in the mouse, including early postnatal stress and behavioral measures of mouse learning.

该副本是利用资源的众多研究子项目之一 由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持 而且，副投影的主要研究员可能是其他来源提供的 包括其他NIH来源。 列出的总费用可能 代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。 已显示压力会改变与学习有关的神经系统的发展（尤其是情境，提示和灭绝学习）和认知控制。人类和小鼠中的新兴证据表明，压力经历会导致BDNF水平的特定区域变化。该项目的总体目的是检验以下假设：BDNF基因中的Val66met多态性将适应早期生命压力（以制度/孤儿饲养的形式）对髋乳状体，杏仁核和腹膜前乳状细胞cortex的影响（以制度/孤儿饲养的形式），包括earbital cortex（包括Orbital Cortex）。参与者将是12-14岁的儿童，在年龄在4个月和5年之间的国际收养中，他们在机构（医院，孤儿院）居住了75％或以上的预购前生活。我们将检验以下假设：BDNF Val66met多态性将调节早期应力（剂量/机构护理持续时间）对这些区域的结构和功能的影响。我们还将检查这些影响是否随着收养家庭的时间而减少。该项目是NIMH中心赠款的一部分，该项目包括其他项目，该项目涉及BDNF基因型对8-18岁年龄段的典型发展中学习和认知控制的影响（纽约的萨克勒研究所），以及val66mmet多态性的敲门基因模型，包括小鼠的早期压力和小鼠学习的早期压力和行为测量。