PROTEIN PHOSPHORYLATION IN YEAST VACUOLE FUSION

酵母液泡融合中的蛋白质磷酸化

• 批准号: 7957800
• 负责人: Alexey Jarrell Merz
• 金额: $ 0.33万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-01 至 2010-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7957800
• 关键词: Biology; Chimeric Proteins; Complex; Computer Retrieval of Information on Scientific Projects Database; Docking; Funding; Fungal Genome; Goals; Grant; Institution; Membrane Fusion; Phosphorylation; Proteins; Research; Research Personnel; Resources; Role; SNAP receptor; Source; United States National Institutes of Health; Vacuole; Yeasts; interest; rab GTP-Binding Proteins

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We are interested in the roles of several proteins involved in yeast vacuole membrane fusion, including a Rab GTPase (Ypt7p), its effector complex (HOPS), and vacuolar SNARE proteins (Vam3p, Vam7p, Vti1p, Nyv1p). Our goal is to generate a phosphorylation profile of known docking and fusion proteins, and to identify new fusion machinery.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 我们对参与酵母液泡膜融合的几种蛋白质的作用感兴趣，包括 Rab GTPase (Ypt7p)、其效应复合物 (HOPS) 和液泡 SNARE 蛋白 (Vam3p、Vam7p、Vti1p、Nyv1p)。我们的目标是生成已知对接和融合蛋白的磷酸化图谱，并识别新的融合机制。