WORKSHOP ON BIOLOGICAL SMALL ANGLE X-RAY SCATTERING AND DIFFRACTION STUDIES IN S

生物小角X射线散射和衍射研究研讨会

• 批准号: 8169960
• 负责人: HIROTSUGU TSURUTA
• 金额: $ 4.07万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8169960
• 关键词: Biological; Complement; Computer Retrieval of Information on Scientific Projects Database; Computing Methodologies; Crystallography; Data; Educational workshop; Fiber; Funding; Grant; Hour; Institution; Lipids; Measures; Participant; Research; Research Personnel; Resolution; Resources; Sampling; Solutions; Source; Synchrotrons; System; Techniques; Time; United States National Institutes of Health; interest; lecturer; lectures; structural biology; tool

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Center hosted a workshop on primarily non-crystalline x-ray diffraction studies in structural biology on April 9-12, 2009. It consisted of 2 days of lectures and 2 days of practical sessions. The lectures covered theoretical and experimental aspects of x-ray scattering by non-crystalline matter, computational methods for data interpretation as well as some of most recent research results. The primary focus of the workshop was solution x-ray scattering studies, which currently make up over 50% of beam time allocation on BL4-2. The workshop also covered related topics including recent lipid and fiber x-ray diffraction studies which deal with partially ordered systems. The majority of the participants uses macromolecular crystallography as their primary structural tool, and was interested in using non-crystalline diffraction techniques, primarily solution x-ray scattering, to complement their higher resolution structural studies. There were 15 lecturers/tutors and 20 participants in the workshop, including several from similar Centers from other synchrotron facilities. Approximately 2 hours of beam time on BL4-2 was allocated to each of ten participants in the experimental practical sessions to measure their own samples. The SMB staff hosted these experimental sessions, and Dmitri Svergun (EMBL-Hamburg) and SJ Kim (Sali group, UCSF) led computational practical sessions, which were attended by most of the participants and many lecturers. Some of the workshop participants later submitted rapid access or standard experimental proposals to continue their studies.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 该中心于2009年4月9日至12日举办了一个关于结构生物学的主要非结晶X射线衍射研究的研讨会。它包括2天的讲座和2天的实践会议。这些讲座涵盖了非晶体物质X射线散射的理论和实验方面，数据解释的计算方法以及一些最新的研究结果。研讨会的主要重点是解决方案X射线散射研究，该研究目前占BL4-2上光束时间分配的50％以上。该研讨会还涵盖了相关主题，包括最近有序系统的脂质和纤维X射线衍射研究。大多数参与者使用大分子晶体学作为其主要结构工具，并且有兴趣使用非结晶衍射技术（主要是溶液X射线散射）来补充其更高分辨率的结构研究。研讨会中有15名讲师/导师和20名参与者，其中包括来自其他同步设施的类似中心的几个。 BL4-2上大约2小时的光束时间分配给实验实践会话中的十个参与者中的每一个，以测量自己的样品。 SMB的工作人员主持了这些实验性会议，DMITRI Svergun（Embl-Hamburg）和SJ Kim（Sali Group，UCSF）主持了计算实践课程，大多数参与者和许多讲师都参加了计算实践课程。一些研讨会参与者后来提交了快速访问或标准的实验建议，以继续学习。