CEREBRAL AUTOREGULATION OF VERY LOW BIRTH WEIGHT, PREMATURE INFANTS

极低出生体重早产儿的大脑自动调节

• 批准号: 8361964
• 负责人: Turgut Durduran
• 金额: $ 1.54万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-06-01 至 2012-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8361964
• 关键词: Affect; Blood capillaries; Blood flow; Brain Injuries; Cerebrovascular Circulation; Cerebrum; Diffuse; Funding; Future; Grant; Hemorrhage; Homeostasis; Infant; Injury; Lead; Low Birth Weight Infant; Magnetic Resonance; Measures; Methods; Monitor; National Center for Research Resources; Patients; Periventricular Leukomalacia; Population; Premature Infant; Principal Investigator; Research; Research Infrastructure; Resources; Risk; Source; Spectrum Analysis; Techniques; United States National Institutes of Health; Very Low Birth Weight Infant; capillary; cost; intraventricular hemorrhage; optical imaging

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Preterm very-low-birthweight (VLBW) infants are at significant risk of brain injury due to their immature ability to regulate cerebral blood flow (CBF). Two of the most common brain injuries affecting this patient group are intraventricular hemorrhage (IVH) and periventricular leukomalacia (PVL). The onsets of both IVH and PVL are highly dependent on changes in CBF. For example, in the case of IVH, a decrease in blood flow can cause injury to immature capillary vessels in the germinal matrix. This damage can lead to hemorrhage if flow increases in the future. This study aims to investigate whether diffuse correlation spectroscopy (DCS) could be used to measure blood flow changes in this delicate population. Because of these infants' fragile condition, there exist few methods to evaluate their CBF. None of these techniques are able to monitor continuously at the bedside.

该子项目是利用资源的众多研究子项目之一 由 NIH/NCRR 资助的中心拨款提供。子项目的主要支持 并且子项目的主要研究者可能是由其他来源提供的， 包括其他 NIH 来源。 子项目可能列出的总成本 代表子项目使用的中心基础设施的估计数量， NCRR 赠款不直接向子项目或子项目工作人员提供资金。 早产极低出生体重（VLBW）婴儿由于其​​身体原因而面临脑损伤的显着风险 调节脑血流（CBF）的能力不成熟。两种最常见的脑损伤 影响该患者群体的是脑室内出血 (IVH) 和脑室周围出血 脑白质软化症（PVL）。 IVH 和 PVL 的发作高度依赖于 CBF 的变化。 例如，在 IVH 的情况下，血流量减少可能会导致未成熟毛细血管损伤 生发基质中的血管。如果将来流量增加，这种损伤可能会导致出血。 本研究旨在探讨漫相关光谱（DCS）是否可用于 测量这个脆弱人群的血流变化。由于这些婴儿的身体状况十分脆弱， 评估他们的 CBF 的方法很少。这些技术都无法监控 不断守在床边。