DEVELOPMENT OF DIFFUSE OPTICS FOR BED-SIDE MONITORING

开发用于床边监测的漫射光学器件

• 批准号: 7955322
• 负责人: Turgut Durduran
• 金额: $ 3.34万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-06-01 至 2010-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7955322
• 关键词: Acute; Beds; Blood; Blood flow; Brain; Brain Diseases; Cerebrovascular Circulation; Cerebrum; Computer Retrieval of Information on Scientific Projects Database; Data; Development; Diffuse; Functional disorder; Funding; Future; Grant; Hemoglobin; Human; Hybrids; Institution; Laboratories; Magnetic Resonance; Measures; Metabolism; Methodology; Monitor; Near-Infrared Spectroscopy; Optics; Oxygen; Patients; Personal Satisfaction; Physiology; Play; Public Health; Research; Research Personnel; Resources; Role; Side; Source; Spectrum Analysis; Stroke; Surrogate Markers; Technology; Time; Tissues; United States National Institutes of Health; acute stroke; base; improved; new technology; optical imaging

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Diffuse optics holds a great deal of promise for implementation as a bedside monitor of blood flow, blood oxygen saturation and oxygen metabolism in the brain. Near-infrared spectroscopy (NIRS) for measuring blood oxygen saturation and total hemoglobin concentration has been under development for some time, and significant progress has been made. Our laboratory has played a leading role at the forefront of this subfield. Recently, we have introduced a new technology called diffuse correlation spectroscopy (DCS) that permits us to measure tissue blood flow. By combining these two methodologies together in a hybrid technology, we can now obtain a better picture of the underlying brain physiology and can even estimate brain oxygen metabolism as a surrogate marker of cerebral well-being. The key feature of the diffuse optical approach is its potential as a continuous, non-invasive, quantitative monitor at the bedside. We expect that it will have future applications to other brain disorders, but because of the clear rationale and immense public health significance of stroke, we have recently elected to focus effort on the management of acute, cortical strokes. By developing this bedside monitor, we hope that patient management that often focuses on optimization of cerebral blood flow can be utilized and individualized based on the underlying pathophysiology of each patient. We have now demonstrated their use in functional activation studies of intact human brain and patients with acute stroke. Further theoretical, algorithmic, and technological developments are necessary to improve the fidelity of the data.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 漫射光学器件在床边血流监测方面具有广阔的应用前景， 血氧饱和度和大脑中的氧代谢。 近红外光谱 (NIRS) 用于测量血氧饱和度和总血红蛋白浓度 经过一段时间的发展，取得了重大进展。 我们实验室玩过 在该子领域的前沿发挥主导作用。 最近，我们推出了一项新技术 称为弥散相关光谱（DCS），它使我们能够测量组织血流量。 经过 将这两种方法结合在混合技术中，我们现在可以获得更好的 基本大脑生​​理学的图像，甚至可以估计大脑氧代谢 大脑健康的替代指标。 漫射光学方法的主要特点是 作为床边连续、非侵入性定量监测的潜力。 我们期望它 未来将应用于其他脑部疾病，但由于其明确的原理和 中风对公共卫生具有巨大意义，我们最近选择将重点放在以下方面： 急性皮质中风的治疗。 通过开发这款床头监护仪，我们希望 可以利用通常侧重于脑血流优化的患者管理 并根据每位患者的潜在病理生理学进行个体化治疗。 我们现在有 证明了它们在完整人脑和患有脑损伤的患者的功能激活研究中的用途 急性中风。 需要进一步的理论、算法和技术发展 以提高数据的保真度。