DEVELOPMENT OF DIFFUSE OPTICS FOR BREAST CANCER IMAGING AND MONITORING

用于乳腺癌成像和监测的漫射光学器件的开发

• 批准号: 7955323
• 负责人: Turgut Durduran
• 金额: $ 3.34万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-06-01 至 2010-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7955323
• 关键词: Area; Blood; Blood Vessels; Breast; Cell Nucleus; Computer Retrieval of Information on Scientific Projects Database; Contrast Media; Death Rate; Development; Diagnosis; Diffuse; Fluorescence; Funding; Generations; Grant; Hemoglobin; Institution; Light; Lipids; Magnetic Resonance; Malignant Neoplasms; Mammary Neoplasms; Medicine; Metabolic; Methods; Mitochondria; Monitor; Nonionizing Radiation; Optical Methods; Optics; Organelles; Oxygen; Perfusion; Population; Process; Property; Research; Research Personnel; Resources; Screening procedure; Sensitivity and Specificity; Source; Spectrum Analysis; Tissues; United States National Institutes of Health; Veins; Water; Woman; absorption; base; cancer imaging; malignant breast neoplasm; minimally invasive; molecular imaging; optical imaging; tool; tumor

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Breast cancer is one of the most common cancers among women worldwide. In order to lower the death rate due to breast cancer, significant improvements in the areas of screening, diagnosis, and therapy monitoring of cancer are imperative. Diffuse optical imaging and spectroscopy methods promise new tools for these applications. The optical methods utilize non-ionizing radiation (e.g. red to infrared light), are non-invasive or minimally-invasive, and are inexpensive, technologically simple and fast. These methods provide several unique parameters based on functional processes in tissues with potential to enhance breast tumor sensitivity and specificity. Tissue optical absorption coefficients provide access to blood dynamics, total hemoglobin concentration, blood oxygen saturation, water concentration and lipid content. These tissue properties are often substantially different in rapidly growing tumors; for example, high concentrations of hemoglobin with low oxygen saturation are suggestive of rapidly growing tumors due to their high metabolic demand and (sometimes) poor perfusion. In a different vein, an increase in organelle population, particularly mitochondria or nuclei, sometimes accompanies the higher metabolic activity of the rapidly growing tumor, and leads to an increase of optical scattering coefficients for the tumor. Finally, optical absorption, fluorescence, and scattering of exogenous contrast agents that occupy vascular and extravascular space also provide useful forms of sensitization. Along these lines, advances in diffuse optical imaging of breast are critical for exploitation of advances in the field of Molecular Imaging, an emerging area of medicine promising development of new generation contrast agents.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 乳腺癌是全世界女性最常见的癌症之一。为了降低 乳腺癌死亡率，筛查、诊断领域的显着改善， 癌症的治疗监测势在必行。 漫射光学成像和光谱学 方法为这些应用提供了新的工具。 光学方法利用非电离 辐射（例如红光到红外光），是非侵入性或微创性的，并且价格便宜， 技术简单且快速。这些方法提供了几个基于 组织中的功能过程有可能增强乳腺肿瘤的敏感性和特异性。 组织光吸收系数提供血液动力学、总血红蛋白的信息 浓度、血氧饱和度、水浓度和脂质含量。这些组织 快速生长的肿瘤的特性通常有很大不同；例如，高 低氧饱和度的血红蛋白浓度表明快速增长 由于肿瘤的高代谢需求和（有时）灌注不良。在不同的 静脉，细胞器数量增加，特别是线粒体或细胞核，有时 伴随着快速生长的肿瘤的更高的代谢活性，并导致 肿瘤的光学散射系数增加。最后，光吸收、荧光、 以及占据血管和血管外空间的外源性造影剂的分散 提供有用的敏化形式。沿着这些思路，漫射光学成像的进展 乳房对于利用分子成像这一新兴领域的进步至关重要 医学界有希望开发新一代造影剂。