DEVELOPMENT OF DIFFUSE OPTICS FOR BREAST CANCER IMAGING AND MONITORING

用于乳腺癌成像和监测的漫射光学器件的开发

• 批准号: 7955323
• 负责人: Turgut Durduran
• 金额: $ 3.34万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-06-01 至 2010-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7955323
• 关键词: Area; Blood; Blood Vessels; Breast; Cell Nucleus; Computer Retrieval of Information on Scientific Projects Database; Contrast Media; Death Rate; Development; Diagnosis; Diffuse; Fluorescence; Funding; Generations; Grant; Hemoglobin; Institution; Light; Lipids; Magnetic Resonance; Malignant Neoplasms; Mammary Neoplasms; Medicine; Metabolic; Methods; Mitochondria; Monitor; Nonionizing Radiation; Optical Methods; Optics; Organelles; Oxygen; Perfusion; Population; Process; Property; Research; Research Personnel; Resources; Screening procedure; Sensitivity and Specificity; Source; Spectrum Analysis; Tissues; United States National Institutes of Health; Veins; Water; Woman; absorption; base; cancer imaging; malignant breast neoplasm; minimally invasive; molecular imaging; optical imaging; tool; tumor

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Breast cancer is one of the most common cancers among women worldwide. In order to lower the death rate due to breast cancer, significant improvements in the areas of screening, diagnosis, and therapy monitoring of cancer are imperative. Diffuse optical imaging and spectroscopy methods promise new tools for these applications. The optical methods utilize non-ionizing radiation (e.g. red to infrared light), are non-invasive or minimally-invasive, and are inexpensive, technologically simple and fast. These methods provide several unique parameters based on functional processes in tissues with potential to enhance breast tumor sensitivity and specificity. Tissue optical absorption coefficients provide access to blood dynamics, total hemoglobin concentration, blood oxygen saturation, water concentration and lipid content. These tissue properties are often substantially different in rapidly growing tumors; for example, high concentrations of hemoglobin with low oxygen saturation are suggestive of rapidly growing tumors due to their high metabolic demand and (sometimes) poor perfusion. In a different vein, an increase in organelle population, particularly mitochondria or nuclei, sometimes accompanies the higher metabolic activity of the rapidly growing tumor, and leads to an increase of optical scattering coefficients for the tumor. Finally, optical absorption, fluorescence, and scattering of exogenous contrast agents that occupy vascular and extravascular space also provide useful forms of sensitization. Along these lines, advances in diffuse optical imaging of breast are critical for exploitation of advances in the field of Molecular Imaging, an emerging area of medicine promising development of new generation contrast agents.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 乳腺癌是全球女性中最常见的癌症之一。为了降低 乳腺癌引起的死亡率，筛查，诊断区域的显着改善， 癌症的治疗监测必须进行。 弥散光学成像和光谱 方法为这些应用程序提供新工具。 光学方法利用非电离 辐射（例如红色到红外光），无创或微不足道，并且很便宜， 技术上简单而快速。这些方法基于 具有增强乳腺肿瘤敏感性和特异性的组织中的功能过程。 组织光吸收系数可提供血液动力学，总血红蛋白 浓度，血氧饱和度，水浓度和脂质含量。这些组织 在快速生长的肿瘤中，特性通常大不相同。例如，高 低氧饱和度的血红蛋白浓度暗示着快速生长 肿瘤由于其高代谢需求而引起的（有时）灌注不良。在不同的地方 静脉，细胞器种群的增加，尤其是线粒体或核，有时 伴随着快速生长的肿瘤的代谢较高，并导致 肿瘤的光散射系数增加。最后，光吸收，荧光， 以及占据血管和血管外空间的外源性对比剂的散射 提供有用的敏化形式。沿着这些行，弥漫性光学成像的进步 乳房对于剥削分子成像领域的进步至关重要，这是一个新兴区域 医学有望开发新一代对比剂。