CEREBRAL AUTOREGULATION OF VERY LOW BIRTH WEIGHT, PREMATURE INFANTS

极低出生体重早产儿的大脑自动调节

• 批准号: 7723830
• 负责人: Turgut Durduran
• 金额: $ 1.09万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-06-01 至 2009-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7723830
• 关键词: Affect; Beds; Blood capillaries; Blood flow; Brain Injuries; Cerebrovascular Circulation; Cerebrum; Computer Retrieval of Information on Scientific Projects Database; Condition; Diffuse; Funding; Future; Grant; Head; Hemorrhage; Homeostasis; Hybrids; Infant; Injury; Institution; Invasive; Lead; Low Birth Weight Infant; Magnetic Resonance Imaging; Measurement; Measures; Methods; Modality; Monitor; Optics; Patients; Perfusion; Periventricular Leukomalacia; Personal Satisfaction; Population; Positioning Attribute; Premature Infant; Relative (related person); Research; Research Personnel; Resources; Risk; Source; Spectrum Analysis; Spin Labels; Techniques; Ultrasonography; United States National Institutes of Health; Validation; Very Low Birth Weight Infant; capillary; instrument; intraventricular hemorrhage

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Preterm very-low-birthweight (VLBW) infants are at significant risk of brain injury due to their immature ability to regulate cerebral blood flow (CBF). Two of the most common brain injuries affecting this patient group are intraventricular hemorrhage (IVH) and periventricular leukomalacia (PVL). The onsets of both IVH and PVL are highly dependent on changes in CBF. For example, in the case of IVH, a decrease in blood flow can cause injury to immature capillary vessels in the germinal matrix. This damage can lead to hemorrhage if flow increases in the future. This study aims to investigate whether diffuse correlation spectroscopy (DCS) could be used to measure blood flow changes in this delicate population. Because of these infants' fragile condition, there exist few methods to evaluate their CBF. None of these techniques are able to monitor continuously at the bedside. DCS was developed in our lab, and it has been well validated against other blood flow methodalities such as arterial spin labelling perfusion MRI. It is portable, non-invasive, and relatively inexpensive, making it an ideal method to study this patient population. A hybrid diffuse optical spectroscopy (DOS) and DCS instrument is used to determine relative cerebral blood flow (rCBF) and oxygenation changes during changes in head- of-bed position. Subsequent validation measurements are also performed during head-of-bed changes by Doppler head ultrasound, and the results from the two modalities were compared.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 早产非常低血压（VLBW）婴儿因其脑部损伤而受到重大风险 调节脑血流（CBF）的不成熟能力。最常见的两个脑损伤 影响该患者组的是脑室内出血（IVH）和脑室周围 白细胞（PVL）。 IVH和PVL的攻击高度取决于CBF的变化。 例如，在IVH的情况下，血流减少会导致未成熟毛细管的伤害 生发基质中的血管。如果流动增加，这种损害可能导致出血 未来。这项研究旨在研究弥漫性相关光谱（DC）是否可能是 用于测量这种细腻的人群中的血流变化。因为这些婴儿的脆弱 条件，很少有评估其CBF的方法。这些技术都无法 在床边连续监视。 DC是在我们的实验室中开发的，而且很好 对其他血流方法（例如动脉自旋标记灌注MRI）进行了验证。它 是便携式，无创和相对便宜的，使其成为研究这一点的理想方法 患者人数。混合散射光谱（DOS）和DCS仪器用于 确定相对脑血流（RCBF）和头部变化期间的氧合变化 床位的位置。随后的验证测量还在床头主管期间进行 多普勒头超声的变化，并比较了两种方式的结果。