DEVELOPMENT OF DIFFUSE OPTICS FOR BED-SIDE MONITORING

开发用于床边监测的漫射光学器件

• 批准号: 7723823
• 负责人: Turgut Durduran
• 金额: $ 3.26万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-06-01 至 2009-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7723823
• 关键词: Acute; Beds; Blood; Blood flow; Brain; Brain Diseases; Cerebrovascular Circulation; Cerebrum; Computer Retrieval of Information on Scientific Projects Database; Data; Development; Diffuse; Functional disorder; Funding; Future; Grant; Hemoglobin; Human; Hybrids; Image; Institution; Laboratories; Measures; Medical; Metabolism; Methodology; Monitor; Near-Infrared Spectroscopy; Optics; Oxygen; Patients; Personal Satisfaction; Physiology; Play; Public Health; Research; Research Personnel; Resources; Role; Side; Source; Spectrum Analysis; Stroke; Surrogate Markers; Technology; Time; Tissues; United States National Institutes of Health; acute stroke; base; improved; new technology

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Diffuse optics holds a great of promise as a bed-side monitor as a monitor of blood flow, tissue blood oxygen saturation and oxygen metabolism in the brain. Near-Infrared spectroscopy (NIRS) and imaging has been under development for some time, and significant progress has been made. Our laboratory has played a leading role at the forefront of this subfield. Recently, we have introduced a new technology called diffuse correlation spectroscopy (DCS) which permits us to measure tissue blood flow as well as blood oxygen saturation and total hemoglobin concentration. By combining these methodologies together in a hybrid technology, we can now obtain a better picture of the underlying brain physiology and we can even estimate brain oxygen metabolism as a surrogate marker of cerebral well-being. The key feature of the diffuse optical approach is its potential as a continuous, noninvasive, quantitative monitor at the bedside. We expect that it will have future applications to other brain disorders, but because of the clear rationale and immense public health significance of stroke, we have recently elected to focus effort on the management of acute, cortical strokes. By developing a stroke monitor, we hope that the medical management which often focuses on optimization of cerebral blood flow can be optimized and individualized based on the underlying pathophysiology of each patient. We have now demonstrated their use in functional activation studies of intact human brain and patients with acute stroke. Further theoretical, algorithmic and technological developments are necessary to improve the fidelity of these data.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 作为床位监视器作为血流的监测器，弥漫性光学器件具有巨大的承诺 大脑中的血氧饱和度和氧代谢。 近红外光谱法 （NIRS）和成像已经开发了一段时间，并且取得了重大进展 被制作了。我们的实验室在这个子领域的最前沿发挥了领导作用。 最近， 我们引入了一种称为弥漫相关光谱（DC）的新技术，该技术 允许我们测量组织血流以及血氧饱和度和总血红蛋白 专注。通过将这些方法结合在一起与混合技术相结合，我们现在可以 获取潜在脑生理学的更好图片，我们甚至可以估计脑氧气 代谢是脑健康的代孕标志。弥漫性光学的关键特征 方法是它作为床边连续的，无创的定量监视器的潜力。 我们 期望它将对其他脑部疾病有未来的应用，但由于很清楚 基本原理和中风的巨大公共卫生意义，我们最近选择集中精力 急性皮质中风管理的努力。通过开发中风监视器，我们希望 通常专注于优化脑血流的医疗管理可以是 根据每个患者的基本病理生理学进行了优化和个性化。 我们有 现在证明了它们在完整的人脑和患者的功能激活研究中的使用 急性中风。进一步的理论，算法和技术发展是必要的 提高这些数据的保真度。