Advanced Knee ASL Imaging at 7T

7T 先进膝关节 ASL 成像

• 批准号: 10658674
• 负责人: Xiufeng Li
• 金额: $ 36.92万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-06-01 至 2027-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10658674
• 关键词: Address; Adipocytes; Adolescent; Adult; Affect; Algorithms; Blood; Blood capillaries; Blood flow; Bone Development; Bone Marrow; Brain; Clinical; Clinical Research; Communities; Degenerative polyarthritis; Development; Diagnostic; Disease; Disease Progression; Echo-Planar Imaging; Etiology; Family; Functional disorder; Goals; Healthcare; Image; Knee; Knowledge; Lesion; Libraries; Logistic Regressions; Magnetic Resonance Imaging; Measures; Methodology; Methods; Modeling; Monitor; Noise; Nomograms; Osteochondritis Dissecans; Patients; Performance; Perfusion; Physiologic pulse; Physiological; Physiology; Play; Population; RF coil; ROC Curve; Research; Role; Safety; Signal Transduction; Slice; Speed; System; Technology; Therapy Evaluation; Time; Tissue Viability; Tissues; Uncertainty; arterial spin labeling; bone; bone repair; cohort; design; experience; healing; human model; imaging modality; imaging platform; imaging study; improved; insight; magnetic field; new technology; next generation; novel; prognostic performance; research study; response; safety assessment; skeletal disorder; software systems; tool; transmission process; treatment response; virtual; virtual model

Abstract Bone marrow perfusion can provide essential knowledge about bone physiology, improve our understanding of disease etiology and pathophysiology, assist the differentiation between normal and abnormal bone marrow, and assess the response to prescribed therapies. Arterial spin labeling (ASL) magnetic resonance imaging (MRI), as a noninvasive and non-contrast-enhanced approach, is well suited for longitudinal monitoring of disease progression and routine evaluation of therapy response. But as revealed by our recent studies, there exist technical challenges (e.g., low signal-to-noise (SNR) ratio due to significantly low perfusion in epiphyseal yellow bone marrow mainly consisting of fat cells with a sparse network of capillaries), and methodological limitations (e.g., single slice coverage and impractically long acquisition time for multi-slice imaging at 3T), hampering routine application of ASL imaging in the knee. Ultrahigh (≥7T) magnetic field can specifically benefit ASL imaging and overcome these challenges by increasing SNR, prolonging blood and tissue T1, and improving parallel imaging performance. However, the current clinically approved single-transmit MRI system and associated imaging methods are incapable of managing the transmit B1 (B1+) fields needed to realize the promised improvement in imaging quality, reliability, and robustness of 7T while existing RF coils are unable to provide adequate B1+ coverage for optimal ASL imaging. Our long-term goal is to develop and improve UHF imaging methods to better facilitate scientific research and clinical studies to improve the management of skeletal diseases and patient healthcare. The rationale is that the existing technical challenges for UHF imaging, including ASL, can be overcome or mitigated, ultimately to realize UHF potentials with promised benefits and superior imaging ability. The objective of this proposal is to develop an optimized, safe, and efficient pTx platform for knee ASL imaging (Aim 1), to develop and optimize pTx-integrated knee ASL imaging methods (Aim 2) and to explore their clinical potentials via studies with a cohort of JOCD patients, an ideal testbed for the developed methodologies. Accomplishing these aims will enable us to fully explore and utilize pTx potentials to overcome the existing technical challenges for knee ASL imaging at 7T. Once developed and optimized, the ASL methods, along with the pTx knee imaging platform, will provide clinicians and research community a powerful tool to enrich our insights into disease etiology and pathophysiology and improve the management of not only JOCD but also various impactful common knee diseases (e.g., osteoarthritis). Novel knowledge and experience from our pioneering development will speed up the maturity of new technology toward early approval of the next generation of clinical UHF MRI systems.

抽象的 骨髓灌注可以提供有关骨骼生理学的基本知识，提高我们对 疾病病因和病理生理学，有助于正常和异常骨髓之间的分化， 并评估对规定疗法的反应。动脉自旋标记（ASL）磁共振成像 （MRI）作为一种非侵入性和非对比度增强方法，非常适合纵向监测 疾病进展和治疗反应的常规评估。但是正如我们最近的研究所揭示的那样 存在技术挑战（例如，由于epiphyseal的灌注明显低，信噪比（SNR）比率低（SNR） 黄骨骨髓主要由脂肪细胞组成，毛细血管稀疏网络）和方法论学 局限性（例如，单片覆盖范围和不切实际的多片成像时的不切实际的收集时间）， 阻碍膝盖中ASL成像的常规应用。超高（≥7t）磁场可以特异性地受益 通过增加SNR，延长血液和组织T1并改善ASL成像并克服这些挑战 并行成像性能。但是，当前经临床批准的单经MRI系统和 相关的成像方法无法管理实现的传输B1（B1+）字段 承诺改善7T的成像质量，可靠性和鲁棒性，而现有RF线圈无法 为最佳的ASL成像提供足够的B1+覆盖范围。我们的长期目标是发展和改善UHF 成像方法更好地准备了科学研究和临床研究以改善骨骼的管理 疾病和患者医疗保健。理由是，UHF成像的现有技术挑战， 包括ASL在内，可以克服或缓解，最终以承诺的利益和 出色的成像能力。该建议的目的是开发优化，安全和高效的PTX平台 对于膝盖ASL成像（AIM 1），要开发和优化PTX集成的膝盖ASL成像方法（AIM 2）和 通过与一群JOCD患者的研究探索其临床潜力，这是针对发达的理想测试 方法。实现这些目标将使我们能够充分探索和利用PTX潜力来克服 现有的技术挑战在7T处于7T时。一旦开发和优化，ASL方法， 与PTX膝盖成像平台一起，将为临床医生和研究社区提供一个强大的工具 丰富我们对疾病病因和病理生理学的见解，不仅改善了JOCD的管理 而且还有各种有影响力的常见膝关节疾病（例如骨关节炎）。来自的新知识和经验 我们开创性的开发将加快新技术的成熟度，以及时批准下一个 临床UHF MRI系统的生成。