2011 Excitatory Synapses and Brain Function GRC

2011 兴奋性突触和脑功能 GRC

• 批准号: 8267002
• 负责人: ROGER A NICOLL
• 金额: --
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-06-01 至 2015-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8267002
• 关键词: Alzheimer' s Disease; Attention; Autistic Disorder; Behavior; Biological; Brain; Brain region; Cells; Communication; Defect; Development; Disease; Environment; Epilepsy; Excitatory Synapse; Faculty; Functional disorder; Future; Goals; Human; Impairment; Institutes; Mental Depression; Mental Health; Mental disorders; Methods; Mission; Molecular; Molecular Structure; National Institute of Drug Abuse; National Institute of Mental Health; National Institute of Neurological Disorders and Stroke; Neuraxis; Neurosciences; Parkinson Disease; Participant; Pharmaceutical Preparations; Postdoctoral Fellow; Property; Request for Proposals; Research; Schizophrenia; Scientist; Shapes; Signal Transduction; Site; Stroke; Structural Biologist; Substance Addiction; Substance abuse problem; Synapses; Technology; Traumatic Brain Injury; United States; United States National Institutes of Health; Update; Work; design; driving force; graduate student; improved; information processing; insight; multidisciplinary; nervous system disorder; neural circuit; novel strategies; programs; sound; symposium; synaptic function

DESCRIPTION (provided by applicant): This proposal requests R13 support for a longstanding, well-attended, and well-received Gordon Research Conference (GRC) on Excitatory Synapses and Brain Function. The synapse is central to our understanding of circuit function and behavior. In the central nervous system, excitatory synapses represent the primary means of information processing by local circuits and communication between brain regions. Synapses serve as the site of action for many commonly prescribed medications and their disruption contributes to many neurological and psychiatric disorders. These include schizophrenia, autism, depression, substance abuse and addiction, Parkinson's disease, Alzheimer's disease, traumatic brain injury, stroke and epilepsy. In some cases, synaptic dysfunction is causal in disease, whereas in other cases it represents the downstream sequelae of one or more underlying molecular defects. In either case, a fundamental understanding of the formation, structure, molecular organization, signaling function, and plasticity of synapses is essential to progress in lessening the burden of human neurological disease and for predicting and improving mental health. This conference is unique in its focus on the excitatory synapse, and in its multidisciplinary group of participants including structural biologists, molecular and developmental biologists, cell biologists, biochemists, cell/molecular imagers, biophysicists and neurophysiologists. The conference is intended to relate fundamental insights in excitatory synaptic function to the impairments in synaptic function that occur in disease, as well as the maladaptive plasticity that occurs in substance abuse. The goal of the conference is to identify and highlight fundamental new insights into synaptic function and dysfunction from a thematic approach. The program has been designed to also highlight cutting edge approaches and to stimulate new concepts, methods and technologies within a sound biological framework of fundamental neuroscience. The conference will bring together expert scientists worldwide in an environment that is conducive to discussion and exchange of ideas. The exchange of ideas at this conference has been a driving force for the field. We expect the 2011 GRC on Excitatory Synapses and Brain Function will shape future scientific directions, and provide critical support for the mission of multiple institutes at NIH including NIMH, NINDS, NIDA and NIA.

描述（由申请人提供）：该提案要求R13对兴奋性突触和大脑功能的长期，有影响力和受欢迎的戈登研究会议（GRC）的支持。突触对于我们对电路功能和行为的理解至关重要。在中枢神经系统中，兴奋性突触代表了通过本地电路和大脑区域之间的通信处理信息处理的主要手段。突触是许多常用药物的行动部位，它们的破坏会导致许多神经系统和精神疾病。其中包括精神分裂症，自闭症，抑郁症，药物滥用和成瘾，帕金森氏病，阿尔茨海默氏病，脑外伤，脑损伤，中风和癫痫病。在某些情况下，突触功能障碍在疾病中是因果关系，而在其他情况下，它代表了一个或多个潜在的分子缺陷的下游后遗症。无论哪种情况，对突触的形成，结构，分子组织，信号传导功能和可塑性的基本理解对于减轻人类神经疾病的负担以及预测和改善心理健康都是必不可少的。这次会议在关注兴奋性突触的关注以及其多学科的参与者组中是独一无二的，包括结构生物学家，分子和发育生物学家，细胞生物学家，生物化学家，细胞/分子成像剂，生物物理学家和神经生理学家。该会议旨在将兴奋性突触功能的基本见解与疾病中发生的突触功能的损害以及在药物滥用中发生的不良适应可塑性相关联。会议的目的是确定并突出基本的新见解，从主题方法中对突触功能和功能障碍。该程序旨在强调最先进的方法，并在基本神经科学的合理生物学框架内刺激新概念，方法和技术。该会议将在有利于讨论和交流思想交流的环境中召集全球专家科学家。在这次会议上的思想交流一直是该领域的推动力。我们预计2011年的兴奋性突触和大脑功能的GRC将塑造未来的科学方向，并为NIH，包括NIMH，Ninds，NIDA和NIA在内的多家机构的任务提供关键的支持。