THE ROLE OF ACTIVITY IN SCULPTING NEURONAL FORM AND FUNCTION

活动在塑造神经元形态和功能中的作用

• 批准号: 8169648
• 负责人: ROGER A NICOLL
• 金额: $ 0.84万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-04-01 至 2011-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8169648
• 关键词: Cells; Computer Retrieval of Information on Scientific Projects Database; Funding; Grant; Institution; Morphology; Mus; N-Methyl-D-Aspartate Receptors; Neurons; Research; Research Personnel; Resources; Role; Source; United States National Institutes of Health; neuronal excitability; time interval

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This project will examine the role of activity in controlling the excitability and morphology of neurons. We have succeeded in making conditional mice in which we can, in a cell autonomous manner, silence all excitatory input to that neuron, by deleting all AMPA and NMDA receptors. These neurons can then be studied over various time intervals after silencing to examine the effects on neuronal excitability and morphology.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 该项目将研究活动在控制神经元的兴奋性和形态中的作用。我们成功地制造了有条件的小鼠，可以通过删除所有AMPA和NMDA受体来以细胞自主的方式使所有兴奋性输入沉默到该神经元。然后，可以在沉默后在各种时间间隔内研究这些神经元，以检查对神经元兴奋性和形态的影响。