A CBPR INVESTIGATION OF TRAFFIC POLLUTION AND CVD IN PUERTO RICAN ADULTS

波多黎各成年人交通污染和心血管疾病的 CBPR 调查

• 批准号: 8238327
• 负责人: Doug Brugge
• 金额: $ 25.5万
• 依托单位: NORTHEASTERN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-04-01 至 2015-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8238327
• 关键词: Address; Adult; Affect; Air; Air Pollutants; Air Pollution; Ankle; Area; Biological Markers; Blood Pressure; Boston; C-reactive protein; Caliber; Cardiovascular Diseases; Cardiovascular system; Cities; Cohort Studies; Commit; Communities; Cross-Sectional Studies; Data; Development; Disease Marker; Double-Blind Method; Educational Materials; Environmental Epidemiology; Environmental Exposure; Ethics; Exposure to; Fibrinogen; Geographic Locations; Goals; Health; High Prevalence; Home environment; Human; Hypertension; IL6 gene; Inflammatory; Intervention; Intervention Studies; Investigation; Knowledge; Laboratories; Link; Literature; Measures; Modeling; Monitor; Morbidity - disease rate; Nature; Participant; Particulate; Particulate Matter; Pathway interactions; Phase; Play; Pollution; Population; Predisposition; Process; Proxy; Public Health; Puerto Rican; Pulse Pressure; Reporting; Research; Risk; Risk Factors; Role; Science; Serum Albumin; Source; Study Section; TNF gene; Testing; Time; Travel; Ultrafine; United States Environmental Protection Agency; Variant; Work; adverse outcome; air filtration; air monitoring; cardiovascular disorder risk; cohort; community based participatory research; density; design; experience; health disparity; indexing; inflammatory marker; interest; member; mortality; operation; particle; pollutant; programs; prospective; randomized trial; research study; residence; stem; success; therapy design; trafficking; ultrafine particle

We have analyzed cross sectional data from the Prospective Cohort of Older Puerto Ricans for the effects of proximity to major roadways and density of traffic near their residences. This analysis did not assess levels of pollution because the cohort study was not originally designed to assess this exposure. Still, using traffic as a proxy, we have demonstrated associations between traffic proximity and hypertension, blood pressure, C-reactive protein and serum albumin. To oiu- knowledge this is the first study to assess traffic exposure and cardiovascular disease (CVD) markers in a Puerto Rican population, a population that has high prevalence of risk factors and cardiovascular diseases. There is competing evidence that fine particulate matter (PM2.5) is associated with CVD. However, this fraction of PM is spread fairly evenly across geographic areas with variation within cities, but little increase next to heavy traffic. Ultrafine particulate pollution (UFP), which are extremely small particles have, however, been shown to be elevated locally near highways and heavily traveled roadways. Research besides ours also has shown associations between proximity to traffic and CVD. Thus, we will address both the role of traffic pollution in health disparities in the Puerto Rican population and develop evidence about whether there is a causal link between UFP and CVD. We propose three community-based participatory research studies that actively engage our community partners in the research process. Study one will build on our preliminary work and develop a model of UFP exposure across our study area in order to test associations of ambient UFP exposure with CVD in the core cohort (project 1 for the center). Study two will install HEPA air filtration in homes of 20 participants in the core cohort and assess whether reducing UFP in the home is associated with improvements in markers of inflammation, including C-reactive protein, IL6, fibrinogen and TNF-a. Study three will develop and disseminate educational materials about traffic-related pollution and CVD to the local Puerto Rican population.

我们分析了波多黎各老年人未来队列的横截面数据，以了解以下因素的影响 靠近主要道路以及住所附近的交通密度。该分析未评估水平 污染，因为队列研究最初并不是为了评估这种暴露而设计的。还是用流量 作为代理，我们证明了交通邻近度与高血压、血压、 C反应蛋白和血清白蛋白。据了解，这是第一项评估波多黎各人群交通暴露和心血管疾病（CVD）标志物的研究，波多黎各人群是危险因素和心血管疾病患病率较高的人群。有相互竞争的证据表明细颗粒物 (PM2.5) 与 CVD 相关。然而，这部分PM在各个地理区域的分布相当均匀，城市内部存在差异，但在交通繁忙的情况下几乎没有增加。然而，超细颗粒物污染（UFP）是极小的颗粒，已被证明在高速公路和交通繁忙的道路附近局部污染程度较高。我们的研究还表明，交通距离与心血管疾病之间存在关联。 因此，我们将解决交通污染在波多黎各人口健康差异中的作用，并就 UFP 和 CVD 之间是否存在因果关系提供证据。我们提出了三项基于社区的参与性研究，积极让我们的社区合作伙伴参与研究过程。研究一将以我们的前期工作为基础，开发整个研究区域的 UFP 暴露模型，以测试核心队列中环境 UFP 暴露与 CVD 的关联（中心项目 1）。研究二将在核心队列中的 20 名参与者的家中安装 HEPA 空气过滤器，并评估减少家中 UFP 是否与炎症标志物（包括 C 反应蛋白、IL6、纤维蛋白原和 TNF-a）的改善相关。研究三将发展并传播 向波多黎各当地居民提供有关交通相关污染和心血管疾病的教育材料。