A CBPR INVESTIGATION OF TRAFFIC POLLUTION AND CVD IN PUERTO RICAN ADULTS

波多黎各成年人交通污染和心血管疾病的 CBPR 调查

• 批准号: 7881853
• 负责人: Doug Brugge
• 金额: $ 22.75万
• 依托单位: NORTHEASTERN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-04-01 至 2015-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7881853
• 关键词: Address; Adult; Affect; Air; Air Pollutants; Air Pollution; Ankle; Area; Biological Markers; Blood Pressure; C-reactive protein; Caliber; Cardiovascular Diseases; Cardiovascular system; Cities; Cohort Studies; Commit; Communities; Cross-Sectional Studies; Data; Development; Disease Marker; Double-Blind Method; Educational Materials; Environmental Epidemiology; Environmental Exposure; Ethics; Exposure to; Fibrinogen; Geographic Locations; Goals; Health; High Prevalence; Home environment; Human; Hypertension; IL6 gene; Inflammatory; Intervention; Intervention Studies; Investigation; Knowledge; Laboratories; Link; Literature; Measures; Modeling; Monitor; Morbidity - disease rate; Nature; Participant; Particulate; Particulate Matter; Pathway interactions; Phase; Play; Pollution; Population; Population Study; Predisposition; Process; Proxy; Public Health; Puerto Rican; Pulse Pressure; Reporting; Research; Risk; Risk Factors; Role; Science; Serum Albumin; Source; Study Section; Testing; Time; Travel; Ultrafine; United States Environmental Protection Agency; Variant; Work; adverse outcome; air filtration; air monitoring; cohort; community based participatory research; density; design; experience; health disparity; indexing; inflammatory marker; interest; member; mortality; operation; particle; pollutant; programs; prospective; randomized trial; research study; residence; stem; success; therapy design; trafficking; ultrafine particle

We have analyzed cross sectional data from the Prospective Cohort of Older Puerto Ricans for the effects of proximity to major roadways and density of traffic near their residences. This analysis did not assess levels of pollution because the cohort study was not originally designed to assess this exposure. Still, using traffic as a proxy, we have demonstrated associations between traffic proximity and hypertension, blood pressure, C-reactive protein and serum albumin. To oiu- knowledge this is the first study to assess traffic exposure and cardiovascular disease (CVD) markers in a Puerto Rican population, a population that has high prevalence of risk factors and cardiovascular diseases. There is competing evidence that fine particulate matter (PM2.5) is associated with CVD. However, this fraction of PM is spread fairly evenly across geographic areas with variation within cities, but little increase next to heavy traffic. Ultrafine particulate pollution (UFP), which are extremely small particles have, however, been shown to be elevated locally near highways and heavily traveled roadways. Research besides ours also has shown associations between proximity to traffic and CVD. Thus, we will address both the role of traffic pollution in health disparities in the Puerto Rican population and develop evidence about whether there is a causal link between UFP and CVD. We propose three community-based participatory research studies that actively engage our community partners in the research process. Study one will build on our preliminary work and develop a model of UFP exposure across our study area in order to test associations of ambient UFP exposure with CVD in the core cohort (project 1 for the center). Study two will install HEPA air filtration in homes of 20 participants in the core cohort and assess whether reducing UFP in the home is associated with improvements in markers of inflammation, including C-reactive protein, IL6, fibrinogen and TNF-a. Study three will develop and disseminate educational materials about traffic-related pollution and CVD to the local Puerto Rican population.

我们已经分析了从旧波多黎各人的前瞻性队列的横截面数据，以实现 靠近其住宅附近的主要道路和交通密度。该分析没有评估水平 污染是因为队列研究最初不是为评估这种暴露而设计的。不过，使用流量 作为代理，我们已经证明了交通接近和高血压，血压， C反应蛋白和血清白蛋白。据了解，这是一项评估波多黎各人口中交通暴露和心血管疾病（CVD）标志物的研究，该人口患危险因素和心血管疾病的患病率很高。有相互竞争的证据表明细颗粒物（PM2.5）与CVD相关。但是，PM的这一小部分在城市内有差异的地理区域均匀分布，但交通繁忙。然而，非常小的颗粒的超铁颗粒污染（UFP）已被证明是在当地高速公路附近升高的，并且行驶时远。除我们的研究外，研究还显示了距交通近距离和CVD之间的关联。 因此，我们将解决波多黎各人口中交通污染在健康差异中的作用，并为UFP和CVD之间的因果关系提供证据。我们提出了三项基于社区的参与性研究，这些研究积极参与研究过程。研究将建立在我们的初步工作的基础上，并在我们的研究领域开发一个UFP暴露模型，以测试核心队列中与CVD的环境UFP暴露的关联（中心的项目1）。研究2将在核心队列中有20名参与者的家庭中安装HEPA空气过滤，并评估减少家居中的UFP是否与炎症标志物的改善有关，包括C反应蛋白，IL6，纤维蛋白原和TNF-A。研究三将发展和传播 有关交通相关污染和CVD的教育材料对当地波多黎各人口。