Sdl: a model for lymphocytic leukemia

Sdl：淋巴细胞白血病模型

• 批准号: 7589883
• 负责人: Lara S Collier
• 金额: $ 7.43万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-17 至 2010-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7589883
• 关键词: Affect; Biological Markers; Cells; Detection; Disease; Disease Progression; Drug Delivery Systems; Event; Gene Expression; Gene Expression Profiling; Genes; Genetic; Genetic Recombination; Genetic Transcription; Genomics; Global Change; Goals; Hematopoietic System; Human; Inherited; Laboratories; Lead; Life; Lymphoblastic Leukemia; Lymphocyte; Maps; Micro Array Data; Modeling; Molecular; Molecular Profiling; Mus; Mutant Strains Mice; Mutation; Oncogenes; Pathway interactions; Penetrance; Phenotype; Pre-Clinical Model; Publishing; Research; Risk Factors; Staging; T-Lymphocyte; Thymus Gland; Tumor Suppressor Genes; base; gain of function mutation; human data; leukemia; male; neoplastic; neoplastic cell; research study

DESCRIPTION (provided by applicant): We are elucidating the genetic basis of leukemia formation by studying the Spontaneous dominant leukemia (Sdl) mouse mutant. The Sdl mutation arose in the germline of a male breeder in our colony, and results in highly penetrant lymphocytic leukemia early in life in mice that inherit the mutation. The germline inheritance combined with disease penetrance approaching 100% in this model provides a unique situation that allows the pre-neoplastic state in the hematopoietic system of these mice to be analyzed. Early molecular changes in cells that will undergo transformation in Sdl mice could serve as biomarkers for the presence of early disease in humans. We hypothesize that studying the Sdl mouse will identify genetic events involved in lymphocytic leukemia initiation and progression and will potentially identify a new human leukemia oncogene.

描述（由申请人提供）： 我们通过研究自发性显性白血病（Sdl）小鼠突变体来阐明白血病形成的遗传基础。 Sdl 突变出现在我们群体中雄性饲养员的种系中，并导致遗传该突变的小鼠在生命早期患上高度渗透性淋巴细胞白血病。该模型中种系遗传与接近 100% 的疾病外显率相结合，提供了一个独特的情况，可以分析这些小鼠造血系统的肿瘤前状态。 Sdl 小鼠中将发生转化的细胞的早期分子变化可以作为人类早期疾病存在的生物标志物。我们假设研究 Sdl 小鼠将鉴定出与淋巴细胞白血病发生和进展有关的遗传事件，并有可能鉴定出一种新的人类白血病癌基因。