PILOT AND EXPLORATORY STUDIES CORE

试点和探索性研究核心

• 批准号: 8206048
• 负责人: GAIL A GREENDALE
• 金额: $ 13.6万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-15 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8206048
• 关键词: Address; Affect; Age; Aging; American; Award; Basic Science; Biological Markers; Bone Marrow; Bone Transplantation; Calculi; Caring; Cell Therapy; Cells; Clinical; Clinical Research; Clinical Sciences; Clinical Trials; Complex; Defect; Development; Diagnostic; Discipline; Doctor of Philosophy; Elderly; Environment; Faculty; Fostering; Funding; Gene Expression; Geriatrics; Goals; Grant; Health; Implantation procedure; Infusion procedures; Instruction; Interdisciplinary Study; Intervention; Laboratories; Lead; Leadership; Mammographic Density; Mandible; Manuscripts; Medicine; Menopause; Mentors; Mentorship; Methodology; Mitochondria; Modeling; Monitor; Muscle; Organ Transplantation; Osteoporosis; Outcome; Pathology; Patients; Peer Review; Physical Function; Pilot Projects; Play; Process; Psychosocial Factor; Reporting; Request for Proposals; Research; Research Infrastructure; Research Personnel; Role; Science; Scientist; Series; Staging; Stromal Cells; Translational Research; Translations; Work; age related; base; career; clinical practice; edentulism; evidence base; falls; functional loss; immunosenescence; improved; innovation; long bone; meetings; multidisciplinary; muscle form; novel; professor; programs; routine practice; sarcopenia; treatment strategy

Overview. The overarching purpose of the UCLA Pilot Exploratory Studies Core (PESC) is to promote innovative basic, clinical and translational research, conducted by collaborating teams of junior and senior investigators, that falls within the UCLA's research theme and carries out the Center's goals. These studies will have one or more of the following objectives: a) provide preliminary studies on which subsequent, larger basic or clinical investigations will be based, b) develop new basic or clinical methodologies that surmount critical barriers to progress in a given discipline, thus opening new research avenues; c) develop novel multidisciplinary research approaches to address complex geriatrics research questions; d) accomplish bidirectional basic and clinical sciences translation; and e) identify diagnostic and/or treatment strategies that bring discoveries to the bedside in order to improve health and optimize function of geriatric patients. Leadership. Gail A. Greendale, MD, Professor of Medicine/Geriatrics, who conducts research in menopause, mammographic density, osteoporosis, & physical functioning, will lead the PESC multidisciplinary team. The co-leaders will be Rita Effros, PhD, Professor of Pathology/Laboratory Medicine, who studies immunosenescence and Peifeng Hu, PhD, MD, Assoc. Professor of Medicine/Geriatrics, who studies relations among biomarkers, psychosocial factors and health outcomes in older adults. Pilot Processes. There will be clear processes for selection of full pilots, monitoring progress of pilots, and developing pilots into independently funded research awards. Selection will consist of a staged process that includes a request for proposals; request for full applications from meritorious applicants; and a series of reviews culminating with final selection by the Executive Committee, External Advisory Board and External Selection Panel. Each pilot will be monitored by a PESC liaison; monitoring will include monthly reports; quarterly meetings with the liaison; annual presentation at the OAIC Seminar Series; and annual presentation to the External Advisors. There will also be a rapid pilot program for which we have set aside $25K to make awards during year 1. The rapid pilot program will make fast-turn-around grants of up to $10,000, to allow the research of junior investigators to advance expediently. Pilots. Three full pilots are proposed. These are: 1) Gene expression analysis of age-related, focal muscle mitochondrial defects;2) Mandibular vs. long bone marrow stromal cell based therapy for implant placement; 3) How do new models of care for older adults spread into routine practice?

概述。 UCLA试点探索性研究核心（PESC）的总体目的是促进由Junior和高级研究人员合作团队进行的创新基础，临床和转化研究，该研究属于UCLA的研究主题，并实现了中心的目标。这些研究将具有以下一个或多个目标：a）提供初步研究，随后，更大的基本或临床研究将基于，b）开发新的基本或临床方法，以确保在给定学科中进步的关键障碍，从而开放新的研究途径； c）开发新型的多学科研究方法来解决复杂的老年医学研究问题； d）完成双向基础和临床科学翻译； e）确定将发现在床边发现的诊断和/或治疗策略，以改善健康患者的健康和优化功能。 领导。医学/老年医学教授Gail A. Greendale医学博士在更年期，乳房X线摄影密度，骨质疏松症和身体功能方面进行研究，将领导PESC多学科团队。共同领导者将是Rita Effros博士，病理学/实验室医学教授，研究Immunosenescence和Peifeng Hu博士，医学博士。医学/老年医学教授，研究老年人生物标志物，心理因素和健康成果之间的关系。 试点过程。将有明确的流程，以选择全面飞行员，监视飞行员的进度以及 将飞行员发展为独立资助的研究奖。选择将包括一个分阶段的过程，其中包括提案请求；请求有功申请人的全部申请；以及一系列评论，最终由执行委员会，外部顾问委员会和外部选择小组进行最终选择。每个飞行员将由PESC联络人监视；监控将包括每月报告；与联络人的季度会议； OAIC研讨会系列的年度演讲；以及向外部顾问的年度介绍。还将有一个快速的试点计划，我们为1年级预留了25000美元的奖励。 $ 10,000，以使初级调查人员的研究可以方便前进。 飞行员。提出了三个完整的飞行员。这些是：1）与年龄相关的局灶性肌肉线粒体缺陷的基因表达分析； 2）下颌与长骨髓基质细胞基于植入物的位置； 3）如何为老年人的新型护理模式扩散到常规练习中？