Colorado Adoption Project/Twin Study of Lifespan behavioral development & cognitive aging [CATSLife2]

科罗拉多州收养项目/终身行为发展的双胞胎研究

• 批准号: 10856816
• 负责人: CHANDRA A REYNOLDS
• 金额: $ 224.88万
• 依托单位: UNIVERSITY OF COLORADO
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-06-01 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10856816
• 关键词: Acceleration; Accounting; Address; Adolescence; Adolescent; Adoption; Adult; Affect; Age; Aging; Alzheimer' s Disease; Alzheimer' s disease risk; Behavioral; Biological Markers; Blood; Body mass index; Buffers; Child; Cognition; Cognitive; Cognitive aging; Colorado; DNA Methylation; Data; Data Collection; Dementia; Development; Disadvantaged; Education; England; Environment; Environmental Risk Factor; Epigenetic Process; Etiology; Exposure to; Follow-Up Studies; Foundations; Genes; Genetic; Genetic Risk; Genotype; Health; Health Services; Health behavior; Health education; Heritability; Human Herpesvirus 4; Immune; Individual; Individual Differences; Inflammatory; Life; Life Style; Light; Longevity; Maintenance; Measures; Mediating; Mediator; Methylation; Modeling; Neighborhoods; Neurotransmitters; Participant; Pathway interactions; Pattern; Performance; Positioning Attribute; Predictive Factor; Prevention; Risk; Risk Factors; Siblings; Signal Transduction; Site; Sleep; Speed; Stress; Testing; Twin Multiple Birth; Twin Studies; Urbanicity; Wales; Work; behavior prediction; cognitive ability; cognitive change; cognitive function; cognitive performance; cognitive reserve; contextual factors; cytokine; design; follow-up; genome-wide; improved; indexing; infancy; microbial; middle age; neurofilament; physical conditioning; predictive marker; proband; prospective; protective factors; resilience; resilience factor; sociodemographics; substance use; transcriptome; transmission process; walkability; young adult; Acceleration; Accounting; Address; Adolescence; Adolescent; Adoption; Adult; Affect; Age; Aging; Alzheimer' s Disease; Alzheimer' s disease risk; Behavioral; Biological Markers; Blood; Body mass index; Buffers; Child; Cognition; Cognitive; Cognitive aging; Colorado; DNA Methylation; Data; Data Collection; Dementia; Development; Disadvantaged; Education; England; Environment; Environmental Risk Factor; Epigenetic Process; Etiology; Exposure to; Follow-Up Studies; Foundations; Genes; Genetic; Genetic Risk; Genotype; Health; Health Services; Health behavior; Health education; Heritability; Human Herpesvirus 4; Immune; Individual; Individual Differences; Inflammatory; Life; Life Style; Light; Longevity; Maintenance; Measures; Mediating; Mediator; Methylation; Modeling; Neighborhoods; Neurotransmitters; Participant; Pathway interactions; Pattern; Performance; Positioning Attribute; Predictive Factor; Prevention; Risk; Risk Factors; Siblings; Signal Transduction; Site; Sleep; Speed; Stress; Testing; Twin Multiple Birth; Twin Studies; Urbanicity; Wales; Work; behavior prediction; cognitive ability; cognitive change; cognitive function; cognitive performance; cognitive reserve; contextual factors; cytokine; design; follow-up; genome-wide; improved; indexing; infancy; microbial; middle age; neurofilament; physical conditioning; predictive marker; proband; prospective; protective factors; resilience; resilience factor; sociodemographics; substance use; transcriptome; transmission process; walkability; young adult

Emerging evidence suggests that individual differences in cognitive aging unfold across a lifetime; however, relatively little is known as to how early life versus proximal influences accumulate to impact cognitive functioning across midlife. The Colorado Adoption/Twin Study of Lifespan behavioral development and cognitive aging (CATSLife) seeks a greater understanding of the environmental and genetic factors that drive increasing divergence in cognitive maintenance. CATSLife comprises the prospective Colorado Adoption Project (CAP) and parallel Longitudinal Twin Study (LTS), now tested at ages 28-45 years (CATSLife1). We propose a 5-year follow-up of 1400 adoptive and nonadoptive probands, siblings, and twins as they navigate the transition to midlife at ages 33-50 years (CATSLife2). Whereas CATSLife1 established baseline performance as participants prepare for transitions to midlife, CATSLife2 proposes to evaluate stability and change across the midlife transition. Further, we propose to integrate the prospective Twins Early Development Study (TEDS) with a new assessment of 5000 twins at age 28 years, allowing us to build on over 20 years of prior data collection, including genome-wide genotyping, to explore similar predictors of cognitive maintenance. As participants transition to midlife, we will leverage powerful design features and a wealth of prospective data collected from infancy through adulthood, including a full adoption design, to examine causal implications of early environmental risk and protective factors, and a twin design to examine environmental factors that may have causal influence on cognition, controlling for familial confounds. As we leverage data from prior assessments with CATSLife1, the opportunity to investigate the transition across midlife with CATSLife2 is ideal. We will use our twin/adoption design with polygenic score data (PGS), detailed cognitive batteries, physical health, proposed biomarkers of accelerated aging that may participate in immune- inflammatory and neurotransmitter pathways, and neighborhood features to shed light on risk-resilience factors that account for midlife cognitive stability and change. This integrated follow-up study of CATSLife and TEDS aims to: 1) Evaluate individual differences in stability and change of cognitive abilities in midlife, considering cognitive reserve pathways vis-a-vis genetic and genetically mediated environmental influences; 2) Evaluate genetic factors with lifestyle and health behaviors that predict cognitive stability and change, considering early life reserve and genetic moderation; 3) Evaluate biomarkers of accelerated aging as predictors and mediators of cognitive stability and change, uniquely characterizing biomarker patterns and change at the midlife transition; and 4) Evaluate stressful and buffering contextual factors that predict cognitive stability and change, addressing individual socio-demographics and neighborhood features, accounting for active (rGE) selection. The findings from this proposed CATSLife/TEDS follow-up study could substantially increase our understanding of the genetic and environmental etiologies of individual differences in cognitive aging.

新兴的证据表明，一生中认知衰老的个体差异；然而， 相对鲜为人知的是，早期生活与近端影响如何积累以影响认知 在中年运作。科罗拉多州的采用/双胞胎研究行为发展和 认知衰老（Catslife）寻求对驱动环境和遗传因素的更多了解 认知维持的差异增加。 Catslife包括潜在的科罗拉多州采用 项目（CAP）和平行纵向双胞胎研究（LTS），现年28-45岁（CATSLIFE1）进行了测试。我们 提议对1400种收养和非辅助概率，兄弟姐妹和双胞胎进行的5年随访。 33-50岁的中年过渡（Catslife2）。而CatsLife1建立了基线 作为参与者准备过渡到中年的表现，CatsLife2建议评估稳定性和 整个中年过渡的变化。此外，我们建议尽早整合潜在的双胞胎 开发研究（TEDS）在28岁时对5000个双胞胎进行了新的评估，使我们能够重复 20年的先前数据收集，包括全基因组基因分型，以探索认知的类似预测指标 维护。作为参与者过渡到中年，我们将利用强大的设计功能和丰富的 从婴儿期到成年期收集的前瞻性数据，包括完整的采用设计，以检查因果关系 早期环境风险和保护因素的含义，以及双重设计来检查环境 可能对认知有因果影响的因素，控制着家族混杂。当我们利用数据时 从对Catslife1进行的先前评估中，调查了中年过渡的机会 CatsLife2是理想的。我们将使用多基因分数数据（PG）使用双胞胎/采用设计，详细的认知 电池，身体健康，提出了加速衰老的生物标志物，可能参与免疫 炎症和神经递质途径，以及邻里的特征，以阐明风险耐力因素 这是中年认知稳定性和变化的原因。这项综合的猫科学家和TED的后续研究 目的是：1）评估中年稳定性和认知能力的变化的个体差异， 认知储备途径对遗传和遗传介导的环境影响； 2）评估 具有预测认知稳定性和变化的生活方式和健康行为的遗传因素，考虑早期 生命储备和遗传适中； 3）评估加速衰老的生物标志物作为预测因素和介体 认知稳定性和变化，唯一地表征了生物标志物模式和中年的变化 过渡; 4）评估预测认知稳定性和变化的压力和缓冲因素， 解决各个社会人口统计学和邻里特征，考虑到主动（RGE）选择。 这项拟议的猫科/TEDS随访研究的发现可能会大大增加我们的 了解认知衰老中个体差异的遗传和环境病因。