Pediatric Neurointensive Care and Resuscitation Research

儿科神经重症监护和复苏研究

• 批准号: 8277415
• 负责人: PATRICK M KOCHANEK
• 金额: $ 26.65万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-25 至 2016-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8277415
• 关键词: Caring; Childhood; Research; Resuscitation

DESCRIPTION (provided by applicant): Acute life-threatening insults in children such as traumatic brain injury (TBI) and cardiac arrest (CA) are leading causes of morbidity and mortality. Injury to the central nervous system from these insults is the key determinant of unfavorable outcome. These neurological and multi- system insults require a multidisciplinary and multi-departmental response that must be coordinated from the field through to rehabilitation. Research training in pediatric neurointensive care and resuscitation is best served by a parallel multidisciplinary and multi- departmental program. Our unique postdoctoral program at the Safar Center for Resuscitation Research, supported by a T32 since 2000, establishes important links across the continuum of care of brain injured infants and children and facilitates rigorous scientific investigation across the key disciplines including pediatric critical care medicine, child neurology, pediatric neurological surgery, pediatric emergency medicine, neonatology, pediatric radiology, and physical medicine and rehabilitation. We train fellows in these pediatric disciplines in basic and clinical research in neurointensive care and resuscitation, linking them to senior scientists. In this competitive renewal application, funds are requested to support 4 positions each yr. Since its inception, the program has filled every position with high-quality fellows who have published numerous peer-reviewed papers and abstracts, and have won many awards. In the last funding cycle, 4 of the 6 graduated fellows have already acquired 5 K awards (two K12s, two K08s, and one K23); many have received advanced degrees. They are highly sought after as faculty; all are in academic positions. The research focus is on injury mechanisms, novel therapies, and outcomes after TBI and CA. We use a bench-to-bedside approach supported by federally funded studies by our faculty. We capitalize on the unique interaction between the Safar Center and the training programs at Children's Hospital of Pittsburgh and the Univ. of Pittsburgh School of Medicine and also take advantages of many unique resources and a Clinical and Translational Science Institute. The director, co-director, and mentors are dedicated, qualified scientists and proven educators. The research areas of each mentor ask important questions, suitable for career development and hypothesis testing. We integrate a curriculum in neurointensive care and involvement on a unique pediatric neurocritical care clinical service. Graduates can formulate, execute, analyze, present and publish experiments designed to answer key questions and are trained in grantsmanship and research integrity. The program has had success in diversity recruitment, notably, in recruiting applicants with disabilities.

描述（由申请人提供）：儿童急性危及生命的损伤，例如创伤性脑损伤（TBI）和心脏骤停（CA）是发病和死亡的主要原因。这些侮辱对中枢神经系统的伤害是不利结果的关键决定因素。这些神经系统和多系统损伤需要多学科和多部门的响应，必须从现场到康复进行协调。儿科神经重症监护和复苏的研究培训最好通过并行的多学科和多部门计划来提供。我们在 Safar 复苏研究中心的独特博士后项目自 2000 年起就得到了 T32 的支持，在脑损伤婴儿和儿童的连续护理中建立了重要的联系，并促进了包括儿科重症监护医学、儿童神经病学在内的关键学科的严格科学研究、小儿神经外科、小儿急诊医学、新生儿学、小儿放射学以及物理医学和康复。我们对这些儿科学科的研究员进行神经重症监护和复苏基础和临床研究的培训，并将他们与资深科学家联系起来。在这个竞争性续约申请中，每年需要资金支持 4 个职位。自启动以来，该项目的各个职位都聘请了高素质的研究员，他们发表了许多同行评审的论文和摘要，并赢得了许多奖项。在上一个资助周期中，6名毕业生中有4人已经获得了5K奖项（2名K12、2名K08和1名K23）；许多人获得了高级学位。他们作为教师受到高度追捧；所有人都担任学术职务。研究重点是 TBI 和 CA 后的损伤机制、新疗法和结果。我们采用从实验室到临床的方法，并得到我们教师的联邦资助研究的支持。我们利用萨法尔中心与匹兹堡儿童医院和大学培训项目之间的独特互动。匹兹堡医学院，还利用许多独特的资源和临床和转化科学研究所。主任、联合主任和导师都是敬业、合格的科学家和久经考验的教育家。每位导师的研究领域都会提出适合职业发展和假设检验的重要问题。我们整合了神经重症监护课程并参与独特的儿科神经重症监护临床服务。毕业生可以制定、执行、分析、展示和发表旨在回答关键问题的实验，并接受资助和研究诚信方面的培训。该计划在多元化招聘方面取得了成功，特别是在招聘残疾申请人方面。