Neurointensive Care and Assessment Facility

神经重症监护和评估设施

基本信息

批准号：
8188836
负责人：
Glen N. Gaulton
金额：
$ 50万
依托单位：
UNIVERSITY OF PENNSYLVANIA
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-07-01 至 2015-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8188836
关键词：
Acute Animal Disease Models Animal Housing Animal Welfare Animals Applied Research Area Behavior assessment Behavioral Biosensor Cardiopulmonary Bypass Caring Cells Closed head injuries Cognitive Development Device or Instrument Development Engineering Ensure Faculty Family suidae Funding Goals Heart Arrest Housing Injury Intensive Care Intensive Care Units Laboratories Machine Learning Molecular Monitor Nervous System Physiology Nervous System Trauma Operative Surgical Procedures Procedures Publications Published Comment Research Research Personnel Safety Schools Security Stroke Technology Testing Therapeutic Intervention Translations Traumatic Brain Injury computerized data processing data integration guide for the care and use of laboratory animals medical schools meetings minimally invasive neurological recovery pre-clinical research research study response

项目摘要

DESCRIPTION (provided by applicant): The overall goal of this G20 proposal is to create a shared Neurointensive Care and Assessment Facility (NCAF) to study acute and long-term responses in large animal models of disease and injury to enable the development and translation of new treatments and technologies that promote and preserve neurological function. This revised proposal responds specifically and substantively to each comment raised in the initial review. The NCAF will be a one-of-a-kind shared porcine facility for the study of neurological injury and recovery after stroke, cardiac arrest, cardiopulmonary bypass, and traumatic brain injury in pigs/piglets d 25kg. The facility will consist of 5 components: (1) a non-sterile procedure room for closed head injuries and terminal procedures, (2) an intensive care housing room, (3) a cognitive and behavioral assessment laboratory, (4) a survival surgical room, and (5) animal prep area. Facilities will be upgraded to allow survival surgery on USDA-regulated species and meet requirements of the Guide for the Care and Use of Laboratory Animals (ILAR, 1996; pre-publication, 2010), and provide a state-of-the art intensive care unit for monitoring and housing animals. Additional space will be renovated to serve as procedural space for cognitive and behavioral assessment using a battery of porcine-specific tests developed by the Facility Director. Finally, the NCAF facility will be upgraded to meet federal and other regulatory requirements that ensure safety, sanitization, security, vermin control and environmental control for surgery, experimental procedure, intensive care housing and behavioral study areas. The NCAF will be used for the study of more than 800 piglets/pigs per year, and will be shared by 25 investigators spanning the School of Medicine (SOM) and School of Engineering and Applied Science (SEAS) with over $42, million in current and pending funding. Moreover, this new facility will be a unique opportunity to create synergy between SOM faculty investigating cell and molecular approaches to therapeutic interventions that preserve neurofunction, with SEAS faculty who are innovators in device development, data integration, data processing, machine learning, biosensors and minimally invasive surgical technology. Thus, these renovations will enhance PHS-funded research, will advance the conduct of animal welfare in experimental research, and will positively impact the scope and pace of the preclinical research at Penn.

描述（由申请人提供）：该G20提案的总体目标是创建共享的神经性护理和评估设施（NCAF），以研究大型疾病和损伤的急性和长期反应，以实现促进和维护神经系统功能的新治疗和技术的发展和翻译。该修订后的提案对初始审查中提出的每个评论进行了专门和实质性的回应。 NCAF将是一种共同的共享猪设施，用于研究中风后的神经系统损伤和康复，心脏骤停，心肺旁路和猪/仔猪D 25kg的脑损伤。该设施将由5个组成部分组成：（1）用于闭合头部受伤和终末程序的非紧密程序室，（2）重症监护室，（3）认知和行为评估实验室，（4）生存手术室，以及（5）动物准备区。将升级设施，以允许对USDA调节的物种进行生存手术，并符合实验动物的护理和使用指南的要求（Ilar，1996; Presublication，2010年），并为监测和住房动物提供了最先进的重症监护病房。将使用设施总监开发的一系列猪特异性测试来对额外的空间进行翻新，以作为认知和行为评估的程序空间。最后，将升级NCAF设施，以满足联邦和其他监管要求，以确保安全，消毒，安全，害虫控制和环境控制，以进行手术，实验程序，重症监护住房和行为研究领域。 NCAF每年将用于研究800多头猪/猪，并将由25名跨越医学院（SOM）和工程学和应用科学学院（SEA）的调查人员共享，目前和尚待资金供应超过42美元，超过4200万美元。此外，这一新设施将是一个独特的机会，可以在研究细胞的SOM教师和分子方法之间进行保留神经功能的干预措施之间的协同作用，而海洋教职员工是设备开发，数据整合，数据处理，机器学习，生物传感器，生物传感器和最小入侵性的外科手术技术的创新者。因此，这些翻新将增强PHS资助的研究，将推进实验研究中的动物福利的行为，并将积极影响宾夕法尼亚大学临床前研究的范围和节奏。