Neurointensive Care and Assessment Facility

神经重症监护和评估设施

基本信息

批准号：
8188836
负责人：
Glen N. Gaulton
金额：
$ 50万
依托单位：
UNIVERSITY OF PENNSYLVANIA
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-07-01 至 2015-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8188836
关键词：
Acute Animal Disease Models Animal Housing Animal Welfare Animals Applied Research Area Behavior assessment Behavioral Biosensor Cardiopulmonary Bypass Caring Cells Closed head injuries Cognitive Development Device or Instrument Development Engineering Ensure Faculty Family suidae Funding Goals Heart Arrest Housing Injury Intensive Care Intensive Care Units Laboratories Machine Learning Molecular Monitor Nervous System Physiology Nervous System Trauma Operative Surgical Procedures Procedures Publications Published Comment Research Research Personnel Safety Schools Security Stroke Technology Testing Therapeutic Intervention Translations Traumatic Brain Injury computerized data processing data integration guide for the care and use of laboratory animals medical schools meetings minimally invasive neurological recovery pre-clinical research research study response

项目摘要

DESCRIPTION (provided by applicant): The overall goal of this G20 proposal is to create a shared Neurointensive Care and Assessment Facility (NCAF) to study acute and long-term responses in large animal models of disease and injury to enable the development and translation of new treatments and technologies that promote and preserve neurological function. This revised proposal responds specifically and substantively to each comment raised in the initial review. The NCAF will be a one-of-a-kind shared porcine facility for the study of neurological injury and recovery after stroke, cardiac arrest, cardiopulmonary bypass, and traumatic brain injury in pigs/piglets d 25kg. The facility will consist of 5 components: (1) a non-sterile procedure room for closed head injuries and terminal procedures, (2) an intensive care housing room, (3) a cognitive and behavioral assessment laboratory, (4) a survival surgical room, and (5) animal prep area. Facilities will be upgraded to allow survival surgery on USDA-regulated species and meet requirements of the Guide for the Care and Use of Laboratory Animals (ILAR, 1996; pre-publication, 2010), and provide a state-of-the art intensive care unit for monitoring and housing animals. Additional space will be renovated to serve as procedural space for cognitive and behavioral assessment using a battery of porcine-specific tests developed by the Facility Director. Finally, the NCAF facility will be upgraded to meet federal and other regulatory requirements that ensure safety, sanitization, security, vermin control and environmental control for surgery, experimental procedure, intensive care housing and behavioral study areas. The NCAF will be used for the study of more than 800 piglets/pigs per year, and will be shared by 25 investigators spanning the School of Medicine (SOM) and School of Engineering and Applied Science (SEAS) with over $42, million in current and pending funding. Moreover, this new facility will be a unique opportunity to create synergy between SOM faculty investigating cell and molecular approaches to therapeutic interventions that preserve neurofunction, with SEAS faculty who are innovators in device development, data integration, data processing, machine learning, biosensors and minimally invasive surgical technology. Thus, these renovations will enhance PHS-funded research, will advance the conduct of animal welfare in experimental research, and will positively impact the scope and pace of the preclinical research at Penn.

描述（由申请人提供）：本 G20 提案的总体目标是创建一个共享的神经重症监护和评估设施 (NCAF)，以研究大型动物疾病和损伤模型的急性和长期反应，从而能够开发和转化促进和保护神经功能的新疗法和技术。该修订后的提案对初步审查中提出的每条意见做出了具体和实质性的回应。 NCAF 将成为一个独一无二的共享猪设施，用于研究猪/仔猪体重 25 公斤的神经损伤和中风、心脏骤停、体外循环和创伤性脑损伤后的恢复。该设施将由 5 个部分组成：(1) 用于闭合性头部损伤和临终手术的非无菌手术室，(2) 重症监护室，(3) 认知和行为评估实验室，(4) 生存手术室(5) 动物准备区。设施将进行升级，以允许对美国农业部监管的物种进行生存手术，并满足实验动物护理和使用指南（ILAR，1996 年；预出版，2010 年）的要求，并提供最先进的重症监护监测和饲养动物的单位。额外的空间将被翻新，作为认知和行为评估的程序空间，使用由设施主任开发的一系列猪专用测试。最后，NCAF 设施将进行升级，以满足联邦和其他监管要求，确保手术、实验程序、重症监护室和行为研究领域的安全、卫生、安保、害虫控制和环境控制。 NCAF 将用于每年超过 800 头仔猪/猪的研究，并将由医学院 (SOM) 和工程与应用科学学院 (SEAS) 的 25 名研究人员共享，当前资金超过 42,000 万美元和待定的资金。此外，这个新设施将是一个独特的机会，可以在研究细胞和分子治疗方法以保护神经功能的治疗干预的 SOM 教员与设备开发、数据集成、数据处理、机器学习、生物传感器和最小化领域的创新者 SEAS 教员之间建立协同作用。侵入性手术技术。因此，这些革新将加强 PHS 资助的研究，将促进实验研究中动物福利的实施，并将对宾夕法尼亚大学临床前研究的范围和步伐产生积极影响。