Translational Research at PENN: Advancing Cures through Interdisciplinary Science

PENN 的转化研究：通过跨学科科学推进治疗

• 批准号: 7879184
• 负责人: Glen N. Gaulton
• 金额: $ 1299.89万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-03-18 至 2013-03-17
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7879184
• 关键词: Address; Award; Basic Science; Behavior; Biology; Businesses; Cancer Biology; Cardiovascular system; Chronobiology; Clinical; Clinical Investigator; Development; Disease; Equipment; Extramural Activities; Extramural Research Facilities Construction Project; Faculty; Floor; Fostering; Funding; Grant; Health behavior; Housing; Human; Inpatients; Location; Medicine; Metabolism; Minority; Mission; Molecular; Occupations; Outpatients; Pennsylvania; Physicians; Physiology; Program Development; Research; Research Support; Schedule; Science; Scientist; Silver; Site; Translational Research; Translations; Universities; clinical application; clinical care; clinical practice; cost; design; gene discovery; improved; member; multidisciplinary; programs; research facility; square foot; technology/technique

DESCRIPTION (provided by applicant): The University of Pennsylvania proposes to catalyze the formation of the PENN Center for Chronobiology through construction of 46,204 gross square feet (gsf) of contiguous space in the Fisher Translational Research Building, thereby uniting basic scientists studying biology and physiology with clinical investigators addressing the impact of chronobiology on human behavior and health. The Fisher Building, a new 405,000 gsf translational research facility scheduled for completion in late 2010, will house multidisciplinary, disease- focused research initiatives in metabolism, cardiovascular biology and cancer. Directly connected to our main inpatient and outpatient clinical facilities, the site is the focal point for translational research led by PENN's CTSA, truly integrating clinical practice with bench science by bringing scientists and physicians together under one roof to exchange ideas on new discoveries, techniques, and technologies. Because of funding limitations, only three of five research floors of the new Fisher Building are currently approved for completion. This proposal seeks funds to complete one additional floor to be designed by and used in support of the Center for Chronobiology. This new Center will unite and augment PENN's outstanding team of interdisciplinary scientists and physicians who have a unique breadth of world-wide expertise in chronobiology. This expertise spans the discovery of genes and molecular mechanisms fundamental to clock function, and encompasses behavior as well as normal physiology and disease mechanisms. Awarding this project enables PENN to coalesce 18 center scholars in a single location, catalyzing formation of the Center and integrating the Center with other research and clinical programs in the Fisher Building. Overall, the proposal will support the research mission of 57 Center members with a total of $155M in active and pending extramural support. The Center will foster new interdisciplinary program and trainee development, target faculty recruitment and guide clinical application, thereby promoting the translation of basic science to improved clinical care. In support of the ARRA, construction on this LEED Silver certified project could initiate immediately upon award issue and design approval. 430 new jobs will be created, supporting both national and local businesses, with a commitment to engaging 20-27% minority company participation. As our highest institutional priority among C06 construction projects, PENN Medicine is prepared to match the C06 award with $18 million of institutional support in construction project costs beyond those provided by the grant, for expanded faculty recruitment and program development, and in moving and new equipment occupancy expenses.

描述（由申请人提供）：宾夕法尼亚大学提议通过在Fisher转化研究大楼内建造46,204平方英尺（GSF）的46,204平方英尺（GSF），从而催化宾夕法尼亚的年代生物学中心，从而使基础研究者与临床研究者进行研究，以解决对人类的影响和人类行为的影响。 Fisher Building是一项新的405,000 GSF转化研究机构，计划于2010年底完成，将在代谢，心血管生物学和癌症方面拥有多学科，以疾病为中心的研究计划。该站点直接连接到我们主要的住院和门诊临床设施，是宾夕法尼亚州CTSA领导的转化研究的焦点，它通过将科学家和医生聚集在一个屋顶下，将临床实践与基准科学真正融合在一起，以交换有关新发现，技术和技术的思想。由于资金限制，新费舍尔大楼的五个研究楼中只有三个被批准完成。该提案寻求资金来完成另一个楼层，以支持并支持计时生物学中心。这个新中心将团结和增强宾夕法尼亚州杰出的跨学科科学家和医生团队，他们在年代生物学方面拥有独特的全球专业知识。这种专业知识涵盖了基因和分子机制的发现，涵盖了时钟功能的基础，并包括行为以及正常的生理和疾病机制。授予该项目使宾夕法尼亚州能够在一个单一的地点结合18个中心学者，催化中心的形成，并将中心与费舍尔大楼中的其他研究和临床计划集成在一起。总体而言，该提案将支持57名中心成员的研究任务，总共有1.55亿美元的积极和未决的壁外支持。该中心将促进新的跨学科计划和受训者的发展，目标教师招聘和指导临床应用，从而促进将基础科学转化为改善临床护理。为了支持ARRA，该LEED银认证项目的建设可以在奖励问题和设计批准后立即启动。将创建430个新工作，以支持国家和地方企业，并致力于参与20-27％的少数民族公司参与。作为我们在C06建设项目中最高的机构优先事项，Penn Medicine准备与C06奖励与赠款超出赠款提供的建筑项目成本的1800万美元的机构支持，以扩大教师招聘和计划开发以及搬迁和新设备占用费用。