Translational Research at PENN: Advancing Cures through Interdisciplinary Science

PENN 的转化研究：通过跨学科科学推进治疗

• 批准号: 7879184
• 负责人: Glen N. Gaulton
• 金额: $ 1299.89万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-03-18 至 2013-03-17
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7879184
• 关键词: Address; Award; Basic Science; Behavior; Biology; Businesses; Cancer Biology; Cardiovascular system; Chronobiology; Clinical; Clinical Investigator; Development; Disease; Equipment; Extramural Activities; Extramural Research Facilities Construction Project; Faculty; Floor; Fostering; Funding; Grant; Health behavior; Housing; Human; Inpatients; Location; Medicine; Metabolism; Minority; Mission; Molecular; Occupations; Outpatients; Pennsylvania; Physicians; Physiology; Program Development; Research; Research Support; Schedule; Science; Scientist; Silver; Site; Translational Research; Translations; Universities; clinical application; clinical care; clinical practice; cost; design; gene discovery; improved; member; multidisciplinary; programs; research facility; square foot; technology/technique

DESCRIPTION (provided by applicant): The University of Pennsylvania proposes to catalyze the formation of the PENN Center for Chronobiology through construction of 46,204 gross square feet (gsf) of contiguous space in the Fisher Translational Research Building, thereby uniting basic scientists studying biology and physiology with clinical investigators addressing the impact of chronobiology on human behavior and health. The Fisher Building, a new 405,000 gsf translational research facility scheduled for completion in late 2010, will house multidisciplinary, disease- focused research initiatives in metabolism, cardiovascular biology and cancer. Directly connected to our main inpatient and outpatient clinical facilities, the site is the focal point for translational research led by PENN's CTSA, truly integrating clinical practice with bench science by bringing scientists and physicians together under one roof to exchange ideas on new discoveries, techniques, and technologies. Because of funding limitations, only three of five research floors of the new Fisher Building are currently approved for completion. This proposal seeks funds to complete one additional floor to be designed by and used in support of the Center for Chronobiology. This new Center will unite and augment PENN's outstanding team of interdisciplinary scientists and physicians who have a unique breadth of world-wide expertise in chronobiology. This expertise spans the discovery of genes and molecular mechanisms fundamental to clock function, and encompasses behavior as well as normal physiology and disease mechanisms. Awarding this project enables PENN to coalesce 18 center scholars in a single location, catalyzing formation of the Center and integrating the Center with other research and clinical programs in the Fisher Building. Overall, the proposal will support the research mission of 57 Center members with a total of $155M in active and pending extramural support. The Center will foster new interdisciplinary program and trainee development, target faculty recruitment and guide clinical application, thereby promoting the translation of basic science to improved clinical care. In support of the ARRA, construction on this LEED Silver certified project could initiate immediately upon award issue and design approval. 430 new jobs will be created, supporting both national and local businesses, with a commitment to engaging 20-27% minority company participation. As our highest institutional priority among C06 construction projects, PENN Medicine is prepared to match the C06 award with $18 million of institutional support in construction project costs beyond those provided by the grant, for expanded faculty recruitment and program development, and in moving and new equipment occupancy expenses.

描述（由申请人提供）：宾夕法尼亚大学提议通过在费舍尔转化研究大楼建造 46,204 总平方英尺 (gsf) 的连续空间来促进宾夕法尼亚大学时间生物学中心的形成，从而联合研究生物学和生理学的基础科学家与临床研究人员一起研究时间生物学对人类行为和健康的影响。费舍尔大楼是一座占地 405,000 gsf 的新转化研究设施，计划于 2010 年底竣工，将容纳代谢、心血管生物学和癌症领域的多学科、以疾病为重点的研究项目。该网站与我们主要的住院和门诊临床设施直接相连，是由 PENN 的 CTSA 领导的转化研究的焦点，通过将科学家和医生聚集在一个屋檐下，就新发现、技术、和技术。由于资金限制，新费舍尔大楼的五个研究楼层目前只有三层获批竣工。该提案寻求资金来完成一个额外的楼层，由时间生物学中心设计并用于支持该中心。这个新中心将团结并增强 PENN 由跨学科科学家和医生组成的杰出团队，他们在时间生物学方面拥有独特的全球专业知识。这种专业知识涵盖了时钟功能基础基因和分子机制的发现，并涵盖了行为以及正常生理学和疾病机制。授予该项目使 PENN 能够将 18 名中心学者聚集在一个地点，促进该中心的形成，并将该中心与费舍尔大楼的其他研究和临床项目整合起来。总体而言，该提案将为 57 名中心成员的研究任务提供总计 1.55 亿美元的积极和待定的外部支持。该中心将促进新的跨学科项目和学员发展、有针对性的师资招聘和指导临床应用，从而促进基础科学向改善临床护理的转化。为了支持 ARRA，这个 LEED 银级认证项目的建设可以在授予奖项和设计批准后立即启动。将创造 430 个新就业岗位，支持国家和地方企业，并承诺让 20-27% 的少数族裔公司参与其中。作为 C06 建设项目中我们机构的最高优先事项，PENN Medicine 准备为 C06 奖项提供 1800 万美元的机构支持，用于超出拨款范围的建设项目成本、扩大教师招聘和项目开发、以及搬迁和新设备占用费用。