Improving Animal Resources at the Clinical Research Bldg

改善临床研究大楼的动物资源

• 批准号: 7087200
• 负责人: Glen N. Gaulton
• 金额: $ 70万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-08-15 至 2009-08-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7087200
• 关键词: animal colony; clinical research; conditioning; housing; medicine; schools

DESCRIPTION (provided by applicant): The overall goals of this program are to increase the quality of animal care and to enhance the quantity of mouse housing space in the Clinical Research Building (CRB) vivarium at the University of Pennsylvania School of Medicine. The CRB is the second largest component of the School's vivaria (12,800 NSF), and supports the research efforts of 75 faculty with more than $90 million in direct costs for biomedical research. The project goal is accomplished through two closely linked specific aims: (1) Improve sanitation by replacing the existing, outmoded tunnel cagewasher and autoclave with new, larger capacity machines; and (2) Renovate ventilation of the rack washer rooms (soiled and clean) and the autoclave areas, thereby exhausting heat and steam to provide comfortable working conditions for facility staff. Penn Medicine is one of the nation's premier biomedical research institutions. Funding from the NIH alone totaled $359 million in FY03. This follows a decade of extraordinary growth (231%). As much of contemporary biomedical research is dependent upon rodent systems/models, it is not surprising that the murine animal colony expanded at >20% annually over this same period. Although Penn Medicine has dramatically expanded research facilities, with over 350,000 net square feet of new research space and animal facilities created since 1990, these increases have not kept pace with the funded research demands of the faculty. The current murine housing capacity is >85% in the CRB, which is operationally at saturation. As a result investigators have been required to restrict the size of their murine colony, which impedes research progress, and the colony of an individual lab is often housed in several locations, thereby increasing the probability of cross facility contamination. Our proposal represents the near-term component of a comprehensive seven-year plan to expand and upgrade the animal vivaria at Penn Medicine. Renovation of the CRB vivarium will have the following positive effects on the School's research programs: Provide state-of-the-art animal care facilities for the School's present and future programmatic needs, including Genetics, Obesity and Diabetes, Neurobiological Behavior, Neurodegenerative Diseases, and Transplantation; Provide enhanced laboratory animal facilities to retain and attract the best scientists to the School; Contribute to the School's ability to retain AAALAC, International accreditation.

描述（由申请人提供）： 该计划的总体目标是提高宾夕法尼亚大学医学院临床研究大楼 (CRB) 动物饲养场的动物护理质量并增加小鼠饲养空间的数量。 CRB 是学院 vivaria（12,800 NSF）的第二大组成部分，支持 75 名教员的研究工作，生物医学研究的直接费用超过 9000 万美元。该项目的目标是通过两个紧密相连的具体目标来实现的：（1）通过用新的、更大容量的机器替换现有的、过时的隧道式笼式清洗机和高压灭菌器来改善卫生条件； (2) 翻新架式清洗室（脏的和干净的）和高压灭菌器区域的通风，从而排出热量和蒸汽，为设施工作人员提供舒适的工作条件。 Penn Medicine 是美国首屈一指的生物医学研究机构之一。 2003 财年，仅 NIH 提供的资金就达 3.59 亿美元。在此之前的十年里，该公司实现了非凡的增长（231%）。由于当代生物医学研究大部分依赖于啮齿动物系统/模型，因此同期鼠科动物种群以每年 20% 以上的速度扩张也就不足为奇了。尽管 Penn Medicine 大幅扩展了研究设施，自 1990 年以来创建了超过 350,000 净平方英尺的新研究空间和动物设施，但这些增加并没有跟上教师资助研究的需求。目前 CRB 的鼠舍容量>85%，处于饱和状态。因此，研究人员被要求限制鼠群的大小，这阻碍了研究进展，而且单个实验室的鼠群通常分布在多个地点，从而增加了跨设施污染的可能性。我们的提案代表了宾夕法尼亚大学医学院扩大和升级动物饲养场的七年综合计划的近期组成部分。 CRB动物园的改造将对学院的研究项目产生以下积极影响： 为学校当前和未来的项目需求提供最先进的动物护理设施，包括遗传学、肥胖和糖尿病、神经生物学行为、神经退行性疾病和移植； 提供增强的实验动物设施，以保留和吸引最优秀的科学家到学校； 有助于学校保持 AAALAC 国际认证。