Increased Barrier Housing at the Clinical Research Building

增加临床研究大楼的隔离住房

基本信息

批准号：
7249064
负责人：
Glen N. Gaulton
金额：
$ 70万
依托单位：
UNIVERSITY OF PENNSYLVANIA
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-07-01 至 2012-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7249064
关键词：
Accreditation Address Adherence Air Andro-Diane Animal Experimentation Animal Housing Animal Welfare Animals Appendix Area Arts Back Behavior Behavioral Biological Models Biomedical Research Boxing Businesses Caring Censuses Clinical Research Clothing Commit Communicable Diseases Computers Condition Containment Core Facility Cryopreservation Custom DNA Development Plans Devices Diabetes Mellitus Direct Costs Discipline Disease Disease Outbreaks Duct (organ) structure Electronics Embryo Employee Ensure Enterobius Environmental air flow Equipment Facility Construction Funding Category Faculty Female Funding Future Gene Transfer Techniques Genetic Genomics Goals Grant Growth Health Home environment House mice Housing Human Resources Illinois Individual Infection Infectious Agent Institution International Intracytoplasmic Sperm Injections Knock-out Laboratories Laboratory Animals Laboratory Research Link Location Maintenance Measures Medicine Metabolic Diseases Metabolism Microinjections Modeling Monitor Mus National Center for Research Resources Neurobiology Neurodegenerative Disorders Neurosciences Numbers Obesity Occupational Safety Oocytes Operative Surgical Procedures Pennsylvania Phase Plexiglas Plexiglass Principal Investigator Probability Procedures Process Program Development Psychiatry Published Comment Purpose Rattus Recording of previous events Research Research Infrastructure Research Personnel Resources Risk Rodent Running Sanitation Schedule Schools Scientist Services Site Visit Sleep Soil Standards of Weights and Measures Strategic Planning Support of Research Surveys System Targeted Research Testing Time Transgenic Organisms Translating Translational Research Transplantation Transplantation Immunology United States National Institutes of Health Universities VX nerve gas Veterinary Medicine Veterinary Schools Vision Work Workplace animal care animal colony animal facility animal resource behavior test blastocyst care delivery cost density design design and construction desire digital disorder prevention embryonic stem cell exhaust experience falls foot improved interdisciplinary approach laboratory facility male medical schools member morris water maze particle planetary Atmosphere pressure prevent programs research and development research facility size sperm cell

Accreditation Address Adherence Air Andro-Diane Animal Experimentation Animal Housing Animal Welfare Animals Appendix Area Arts Back Behavior Behavioral Biological Models Biomedical Research Boxing Businesses Caring Censuses Clinical Research Clothing Commit Communicable Diseases Computers Condition Containment Core Facility Cryopreservation Custom DNA Development Plans Devices Diabetes Mellitus Direct Costs Discipline Disease Disease Outbreaks Duct (organ) structure Electronics Embryo Employee Ensure Enterobius Environmental air flow Equipment Facility Construction Funding Category Faculty Female Funding Future Gene Transfer Techniques Genetic Genomics Goals Grant Growth Health Home environment House mice Housing Human Resources Illinois Individual Infection Infectious Agent Institution International Intracytoplasmic Sperm Injections Knock-out Laboratories Laboratory Animals Laboratory Research Link Location Maintenance Measures Medicine Metabolic Diseases Metabolism Microinjections Modeling Monitor Mus National Center for Research Resources Neurobiology Neurodegenerative Disorders Neurosciences Numbers Obesity Occupational Safety Oocytes Operative Surgical Procedures Pennsylvania Phase Plexiglas Plexiglass Principal Investigator Probability Procedures Process Program Development Psychiatry Published Comment Purpose Rattus Recording of previous events Research Research Infrastructure Research Personnel Resources Risk Rodent Running Sanitation Schedule Schools Scientist Services Site Visit Sleep Soil Standards of Weights and Measures Strategic Planning Support of Research Surveys System Targeted Research Testing Time Transgenic Organisms Translating Translational Research Transplantation Transplantation Immunology United States National Institutes of Health Universities VX nerve gas Veterinary Medicine Veterinary Schools Vision Work Workplace animal care animal colony animal facility animal resource behavior test blastocyst care delivery cost density design design and construction desire digital disorder prevention embryonic stem cell exhaust experience falls foot improved interdisciplinary approach laboratory facility male medical schools member morris water maze particle planetary Atmosphere pressure prevent programs research and development research facility size sperm cell

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项目摘要

DESCRIPTION (provided by applicant): The overall goals of this program are to increase the quality of animal care and to enhance the quantity of mouse housing space in the Clinical Research Building (CRB) vivarium at the University of Pennsylvania School of Medicine. The CRB is the second largest component of the School's vivaria (13,727 SF), and supports the research efforts of 60 faculty with more than $75 million in direct costs for biomedical research. The project goal is accomplished through three closely linked specific aims: (1) Enhance CRB Housing Capacity through Conversion/Renovation of Neighboring Laboratories; (2) Improve Sanitization by Upgrading the CRB Ventilation System and Expanding the Barrier; and (3) Provide Working Conditions that Meet Optimal Occupational Safety Standards for Facility Staff. Penn Medicine is one of the nation's premier biomedical research institutions. Funding from the NIH alone totaled $393 million in FY04. This follows a decade of extraordinary growth (231%). As much of contemporary biomedical research is dependent upon rodent systems/models, it is not surprising that the murine animal colony expanded at >20%annually over this same period. Although Penn Medicine has dramatically expanded research facilities, with over 425,000 net square feet of new research space and animal facilities created since 1990, these increases have not kept pace with the funded research demands of the faculty. The current murine housing capacity is >85% in the CRB, which is operationally at saturation. As a result, investigators have been required to restrict the size of their murine colonies, which impedes research progress. In addition, the colony of an individual lab is often housed in several locations, thereby increasing the probability of cross facility contamination. Our proposal represents the short-term component of a comprehensive seven-year plan to expand and upgrade the animal vivaria at Penn Medicine. Renovation of the CRB vivarium will have the following positive effects on the School's research programs: * Provide state-of-the-art animal care facilities for the School's present and future programmatic needs, including Genetics, Obesity and Diabetes, Neurobiological Behavior, Neurodegenerative Diseases, and Transplantation. * Provide enhanced laboratory animal facilities to retain and attract the best scientists to the School * Contribute to the School's ability to retain AAALAC, International accreditation

描述（由申请人提供）：该计划的总体目标是提高动物护理的质量，并在宾夕法尼亚大学医学院的临床研究大楼（CRB）Vivarium中增加小鼠住房空间的数量。 CRB是学校Vivaria（13,727平方英尺）的第二大组成部分，并支持60位教师的研究工作，其直接成本超过7500万美元用于生物医学研究。项目目标是通过三个紧密相关的特定目标来实现的：（1）通过转换/翻新邻近实验室提高CRB住房能力；（2）通过升级CRB通风系统并扩大屏障来改善消毒；（3）提供符合设施人员最佳职业安全标准的工作条件。宾夕法尼亚医学是美国首屈一指的生物医学研究机构之一。仅NIH的资金在04财年总计3.93亿美元。这是十年的非凡增长（231％）。由于当代生物医学研究的大部分取决于啮齿动物系统/模型，因此同一时期每年每年以> 20％的范围扩展，这并不奇怪。尽管宾夕法尼亚医学已经大大扩展了研究设施，但自1990年以来创建了超过425,000平方英尺的新研究空间和动物设施，但这些增长并没有跟上教师资助的研究要求的步伐。当前的鼠住房容量在CRB中> 85％，在饱和上运行。结果，已经要求研究人员限制其鼠菌落的大小，这阻碍了研究的进展。此外，单个实验室的菌落通常位于多个位置，从而增加了跨设施污染的可能性。我们的建议代表了一项综合七年计划的短期组成部分，以扩大和升级宾夕法尼亚州的动物动物。 CRB Vivarium的翻新将对学校的研究计划产生以下积极影响： *为学校的当前和未来程序需求提供最先进的动物护理设施，包括遗传学，肥胖和糖尿病，神经生物学行为，神经退行性疾病和移植。 *提供增强的实验室动物设施，以保留并吸引最佳科学家进入学校 *有助于学校保留AAAALAC，国际认证的能力