YEAST SPINDLE ASSEMBLY

酵母主轴组件

• 批准号: 8171460
• 负责人: Trisha N. Davis
• 金额: $ 0.14万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-01 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8171460
• 关键词: Area; Cells; Chromosomes; Computer Retrieval of Information on Scientific Projects Database; Disease; Funding; Genetic Materials; Grant; Institution; Kinetochores; Lead; Malignant Neoplasms; Mitotic; Mitotic spindle; Molecular Machines; Pharmaceutical Preparations; Regulation; Research; Research Personnel; Resources; Signal Transduction; Site; Source; United States National Institutes of Health; Yeasts; cancer cell; cancer therapy; disability; success; transmission process

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Proper transmission of genetic material requires the correct assembly and function of a molecular machine called the mitotic spindle. Errors in spindle assembly result in missegregation of the chromosomes and can lead to disability and cancer. Some cancer cells over express components of the kinetochore. The kinetochore, critical for correct spindle assembly, is a site of regulation and checkpoint signaling. Because errors in spindle assembly result in disease, it is important to understand the precise function of each spindle component. Already, cancer therapies targeting mitotic cells have been used with great success. Continued research in this area will lead to new, more specific drugs, whose primary target is diseased cells.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此，可以在其他清晰的条目中表示。列出的机构是 对于中心，这不一定是调查员的机构。 正确的遗传物质需要正确的组装和功能，称为有丝分裂纺锤体。 主轴组装中的错误导致染色体的错误进行分析，并可能导致残疾和癌症。 某些癌细胞超过了动力学的表达成分。 动力学对于正确的主轴组件至关重要，是调节和检查点信号传导的位点。 由于主轴组件的误差会导致疾病，因此了解每个纺锤体成分的精确功能很重要。 靶向有丝分裂细胞的癌症疗法已经成功使用了。 在该领域的持续研究将导致新的，更具体的药物，其主要靶标是患病细胞。