International Retroviral Symposium: Assembly, Maturation and Uncoating

国际逆转录病毒研讨会：组装、成熟和脱壳

基本信息

批准号：
10762858
负责人：
Saveez Saffarian
金额：
$ 2.5万
依托单位：
UNIVERSITY OF UTAH
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-08-14 至 2024-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10762858
关键词：
Acquired Immunodeficiency Syndrome Antiviral Agents Area Australia Binding Biochemical Biochemistry Bioinformatics Biophysical Process Biophysics Boston Cells Chromosomes Collaborations Complex Country Development Discipline Disease Ensure Environment Enzymes Europe Exposure to Female Funding Genome Goals HIV-1 Human Infection Integrase International International Cooperation Life Cycle Stages Location Malignant Neoplasms Membrane Mentors Microscopy Nature Nucleocapsid Proteins Outcome Participant Persons Postdoctoral Fellow Principal Investigator Process Proteolytic Processing Proteomics RNA RNA-Directed DNA Polymerase Research Research Personnel Resolution Retroviridae Reverse Transcription Role Scientist Students System Techniques Time Training Translating Underrepresented Minority United States National Institutes of Health Utah Viral Virion Virus Virus Assembly broadening participation research combat gag-pol Fusion Proteins human disease male meetings minority scientist next generation novel strategies patient engagement programs symposium therapeutic target virology web site young woman

项目摘要

ABSTRACT During the past decades, the International Retroviral Symposium has focused on identifying key interactions essential for viral assembly and maturation with a particular focus on the nucleocapsid protein and its role. The last meeting of the international retroviral symposium was held in Boston at 2019 where we emphasized the role of NC/Gag in assembly highlighting what has been significant progress in this exciting area. In the 12th International Retroviral Symposium (IRS), we aim to expand the conference focus to include uncoating, and more broadly identify molecular interactions that connect various stages of assembly, maturation and uncoating. The conference has traditionally attracted a group of approximately 100 participants from around the globe. In the 12th IRS, we expect a slightly larger pool of participants, approximately 150, based on the broader focus of the symposium and the long period of time since the 11th symposium held in August 2019. Snowbird Utah provides an idyllic location due to its secluded nature and excellent conference support facility, which maximizes participant engagement. The goal of the 12th IRS is to provide a forum and facilitate identification of fundamental biophysical, biochemical, and virological principles governing retroviruses. These principles will in turn guide development of new antivirals, potent lentiviral systems, and better understanding of the role of retroviruses in human disease, all of which are within the focus of NIH. Our invited speakers are a mix of more junior and established principal investigators, represent countries with active retroviral research and include a significant number of female researchers. The majority of NIH funding will be used to broaden the participation of younger and less represented researchers within the symposium. NIH support is critical for training the next generation as well as injecting new ideas into the field. Conference website: https://ramm2023.utah.edu/

抽象的在过去的几十年中，国际逆转录病毒研讨会一直致力于确定关键对病毒组装和成熟至关重要的相互作用，特别关注Nucleocapsid 蛋白质及其作用。国际逆转录病毒研讨会的最后一次会议在波士顿举行 2019年，我们强调了NC/GAG在组装中的作用，强调了重要的在这个令人兴奋的地区进展。在第12届国际逆转录病毒研讨会（IRS）中，我们旨在扩展会议重点是包括脱衣，并更广泛地确定分子相互作用连接组装的各个阶段，成熟和脱涂层。传统上，该会议吸引了来自大约100名参与者的小组地球。在第12届美国国税局中，我们预计基于大约150的参与者池自第11届研讨会举行以来，研讨会和长时间的更广泛的重点 2019年8月。雪鸟犹他州由于其僻静的性质而提供了一个田园诗般的位置会议支持设施，最大化参与者的参与度。第十二国税局的目标是提供论坛并促进基本生物物理的识别，逆转录病毒的生化和病毒学原理。这些原则又将指南开发新的抗病毒药，有效的慢病毒系统，并更好地理解人类疾病中的逆转录病毒，所有这些都属于NIH的重点。我们受邀的演讲者是更多初级和成熟的首席调查员的组合，代表有积极的逆转录病毒研究的国家，包括大量女性研究人员。这大多数NIH资金将用于扩大年轻人的参与研讨会中的研究人员。 NIH支持对于培训下一代和将新想法注入现场。会议网站：https：//ramm2023.utah.edu/