Animal Tumor Models

动物肿瘤模型

基本信息

批准号：
8181101
负责人：
Ruby Yanru Chen-Tsai
金额：
$ 15.32万
依托单位：
STANFORD UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-09-15 至 2015-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8181101
关键词：
Animal Experimentation Animal Model Animals Antineoplastic Agents Area Arts Brain Calendar Cancer Center Complex Consultations Cost Savings Data Data Collection Databases Development Embryo Etiology Funding Future Genes Goals Histology Histopathology Human Immunohistochemistry Individual Journals Kidney Neoplasms Knockout Mice Malignant Neoplasms Medicine Microinjections Modality Modeling Mus Mutate Neoplasm Metastasis Pancreas Pathology Peer Review Pharmaceutical Preparations Procedures Process Production Prostate Publications Research Research Personnel Resource Sharing Running Scientific Advances and Accomplishments Screening procedure Services Slide Speed Staining method Stains System Technology Testing Therapeutic Tissues Toxic effect Transgenic Mice Transgenic Organisms Universities cancer prevention comparative cost effective design embryonic stem cell in vivo medical schools meetings member mouse genome mouse model new technology oncology oncology service pre-clinical programs protein expression tissue processing tool treatment strategy tumor tumor growth

项目摘要

The Animal Tumor Models Shared Resource provides services in three major areas including transgenic and knockout mice, preclinical oncology and animal histopathology services. The transgenic and knockout mouse production services were established in 1996 at the School of Medicine with the overall objective of providing genetically modified mouse models and supporting technologies to Stanford investigators at cost-effective rates. The Veterinary Service Center (VSC) in the Department of Comparative Medicine runs the animal histopathology service component of the Shared Resource. Major services include tumor analysis by histology, immunohistochemistry, and pathological interpretation. The preclinical oncology services are new additions to the Animal Tumor Models Shared Resource. These services were funded and established by the Cancer Center to support the development and testing of new compounds and to better meet the growing needs of the Cancer Center members for preclinical animal models and therapeutics. The objectives of the Shared Resource are: ¿ Consultation in all aspects of animal tumor models, including creation and analysis of tumor models and providing a database of tumor models in use by Stanford investigators ¿ Production of transgenic and knockout mice by embryo and embryonic stem cell manipulation and microinjection ¿ Full histopathology services for tissue processing, staining and pathological interpretation ¿ Preclinical oncology services for tumor induction, drug administration, toxicity studies, data collection and analysis Substantial cost savings, efficiencies and scientific advances accrue from providing these services through a centralized facility. The Shared Resource has generated over 500 transgenic and knockout mouse models in the last 5 years, each with multiple independent lines. Over 24,000 histology slides or tissue blocks were processed and over 670 pathology procedures were performed in 2008. The Shared Resource's services were acknowledged or co-authored in hundreds of publications in peer-reviewed journals. In calendar year 2008, Cancer Center members representing nine out of ten Programs utilized the Shared Resource. Future plans for the Shared Resource include implementation of tetraploid complementation to speed up knockout mouse production, expansion of the capacity of histopathology services, and offer services on complex tumor models such as orthotopic brain, prostate, pancreatic or renal tumor models.

动物肿瘤模型共享资源在包括转基因在内的三个主要领域提供服务和淘汰小鼠，临床前肿瘤学和动物组织病理学服务。转基因和淘汰小鼠生产服务于1996年在医学院建立为斯坦福提供一般修改的鼠标模型和支持技术的目的调查人员以具有成本效益的价格。部门的兽医服务中心（VSC）比较医学运行共享资源的动物组织病理学服务部分。主要的服务包括通过组织学，免疫组织化学和病理解释进行肿瘤分析。这临床前肿瘤学服务是动物肿瘤模型共享资源的新补充。这些服务是由癌症中心资助和建立的，以支持开发和测试新化合物，以更好地满足临床前癌症中心成员不断增长的需求动物模型和治疗。共享资源的对象是： »在动物肿瘤模型的各个方面进行咨询，包括创建和分析肿瘤模型并提供斯坦福调查人员使用的肿瘤模型数据库 �通过胚胎和胚胎干细胞操纵以及显微注射 �用于组织加工，染色和病理解释的全部组织病理学服务 �临床前肿瘤诱导，药物管理，毒性研究，数据收集和分析通过提供这些服务的大量成本节省，效率和科学进步。集中设施。共享资源生成了500多个转基因和淘汰鼠标模型在过去的5年中，每种都有多个独立线路。超过24,000个组织学载玻片或组织块是 2008年进行了处理和超过670个病理程序。共享资源的服务在同行评审的期刊中，在数百份出版物中得到了认可或合着。在日历中 2008年，代表十分之九的癌症中心成员利用共享资源。共享资源的未来计划包括实施四倍体完成以加快速度淘汰鼠标生产，组织病理学服务能力的扩展，并提供服务复杂的肿瘤模型，例如原位脑，前列腺，胰腺或肾肿瘤模型。