PREVALENCE OF CORONARY ARTERY CALCIUM IN YOUNG ADULTS

年轻人冠状动脉钙化的患病率

• 批准号: 8174494
• 负责人: CATHERINE S MAO
• 金额: $ 0.37万
• 依托单位: LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-12-01 至 2010-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8174494
• 关键词: Accounting; Adult; Arteries; Blood; Blood Glucose; Blood Pressure; Calcium; Characteristics; Child; Cholesterol; Computer Retrieval of Information on Scientific Projects Database; Coronary artery; Deposition; Diabetes Mellitus; Disease; Elderly; Family history of; Funding; Future; Grant; Heart; Heart Diseases; Inflammation; Institution; Medical; Myocardial Infarction; Non-Insulin-Dependent Diabetes Mellitus; Prevalence; Prevention; Prevention Guidelines; Research; Research Personnel; Resources; Risk; Smoking; Source; United States National Institutes of Health; age group; base; design; heart disease risk; heart imaging; middle age; young adult

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. People with diabetes are more likely to die from heart disease than people without diabetes. In fact, their risk is the same as that of people without diabetes who have already had a heart attack. Therefore, people with diabetes are treated for prevention as aggressively as those with previous heart attacks. Type 2 diabetes (DM2)was previously thought to be an adult disease, but now up to 30% of children with diabetes have DM2. When they develop heart disease is not known and no prevention guidelines exist for children. The risk for heart disease in people with diabetes cannot be accounted for based only on blood sugar and cholesterol levels, family history of heart disease, smoking and blood pressure. Middle-aged and older adults are known to have other characteristics that can predict risk, such as signs of inflammation in the blood, and calcium deposits in the arteries around the heart (seen by heart scans). Not enough is known about heart disease risk in younger people who have DM2. This study will investigate newer characteristics of heart disease risk in young adults with DM2. Signs of inflammation in the blood and calcium deposits in the arteries around the heart will be compared between young adults with DM2 and healthy young adults. If these characteristics in young adults with DM2 show increased risk of heart disease, then future studies can be designed to evaluate medical therapy in this age group and to examine the same characteristics in children with DM2.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 糖尿病患者比没有糖尿病的人更有可能死于心脏病。 实际上，他们的风险与没有糖尿病的人相同。 因此，患有糖尿病患者的预防患者与先前心脏病发作的人一样积极地进行预防。 2型糖尿病（DM2）以前被认为是一种成人疾病，但现在多达30％的糖尿病儿童患有DM2。 当他们发展心脏病时，尚不清楚，并且没有针对儿童的预防准则。 糖尿病患者心脏病的风险不能仅基于血糖和胆固醇水平，心脏病，吸烟和血压的家族病史。 已知中年和老年人具有可以预测风险的其他特征，例如血液中炎症的迹象，以及心脏周围动脉的钙沉积物（可见心脏扫描）。 对于患有DM2的年轻人的心脏病风险还不够。 这项研究将研究DM2年轻人心脏病风险的新特征。 在患有DM2和健康的年轻人的年轻人之间，将比较心脏周围动脉的血液和钙沉积物中炎症的迹象。 如果DM2年轻人的这些特征显示出患心脏病的风险增加，则可以将未来的研究设计用于评估该年龄段的药物治疗，并检查DM2儿童的相同特征。