PREVALENCE OF CORONARY ARTERY CALCIUM IN YOUNG ADULTS

年轻人冠状动脉钙化的患病率

• 批准号: 7952255
• 负责人: CATHERINE S MAO
• 金额: $ 0.37万
• 依托单位: LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-12-01 至 2009-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7952255
• 关键词: Accounting; Adult; Arteries; Blood; Blood Glucose; Blood Pressure; Calcium; Characteristics; Child; Cholesterol; Clinical Research; Computer Retrieval of Information on Scientific Projects Database; Coronary artery; Deposition; Diabetes Mellitus; Disease; Elderly; Family history of; Funding; Future; Grant; Heart; Heart Diseases; Inflammation; Institution; Medical; Myocardial Infarction; Non-Insulin-Dependent Diabetes Mellitus; Prevalence; Prevention; Prevention Guidelines; Research; Research Personnel; Resources; Risk; Smoking; Source; United States National Institutes of Health; age group; base; design; heart disease risk; heart imaging; middle age; young adult

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. People with diabetes are more likely to die from heart disease than people without diabetes. In fact, their risk is the same as that of people without diabetes who have already had a heart attack. Therefore, people with diabetes are treated for prevention as aggressively as those with previous heart attacks. Type 2 diabetes (DM2)was previously thought to be an adult disease, but now up to 30% of children with diabetes have DM2. When they develop heart disease is not known and no prevention guidelines exist for children. The risk for heart disease in people with diabetes cannot be accounted for based only on blood sugar and cholesterol levels, family history of heart disease, smoking and blood pressure. Middle-aged and older adults are known to have other characteristics that can predict risk, such as signs of inflammation in the blood, and calcium deposits in the arteries around the heart (seen by heart scans). Not enough is known about heart disease risk in younger people who have DM2. This study will investigate newer characteristics of heart disease risk in young adults with DM2. Signs of inflammation in the blood and calcium deposits in the arteries around the heart will be compared between young adults with DM2 and healthy young adults. If these characteristics in young adults with DM2 show increased risk of heart disease, then future studies can be designed to evaluate medical therapy in this age group and to examine the same characteristics in children with DM2.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 患有糖尿病的人比没有糖尿病的人更有可能死于心脏病。 事实上，他们的风险与患有心脏病但未患糖尿病的人相同。 因此，糖尿病患者与心脏病患者一样要积极接受预防治疗。 2 型糖尿病 (DM2) 以前被认为是一种成人疾病，但现在高达 30% 的糖尿病儿童患有 DM2。 他们何时患上心脏病尚不清楚，也没有针对儿童的预防指南。 糖尿病患者患心脏病的风险不能仅根据血糖和胆固醇水平、心脏病家族史、吸烟和血压来解释。 众所周知，中老年人具有其他可以预测风险的特征，例如血液中的炎症迹象以及心脏周围动脉中的钙沉积（通过心脏扫描看到）。 对于患有 DM2 的年轻人患心脏病的风险知之甚少。 这项研究将调查患有 DM2 的年轻人心脏病风险的新特征。 将比较患有 DM2 的年轻人和健康年轻人之间的血液炎症迹象和心脏周围动脉的钙沉积。 如果患有 DM2 的年轻人的这些特征显示出患心脏病的风险增加，那么未来的研究可以设计为评估该年龄组的药物治疗，并检查患有 DM2 的儿童的相同特征。