EARLY HYPOPITUITARISM AFTER TRAUMATIC BRAIN INJURY IN CHILDREN
儿童脑外伤后早期垂体机能减退
基本信息
- 批准号:7606175
- 负责人:
- 金额:$ 1万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2007
- 资助国家:美国
- 起止时间:2007-02-01 至 2007-11-30
- 项目状态:已结题
- 来源:
- 关键词:AccountingAcuteAdrenal gland hypofunctionCaringCase StudyCephalicCerebrovascular CirculationChildChildhoodChildhood InjuryComputer Retrieval of Information on Scientific Projects DatabaseControl GroupsCraniocerebral TraumaEtiologyEvaluationFundingGlandGrantHormonalHypopituitarismInjuryInstitutionIntracranial HypertensionLocationMechanicsNon-accidentalPatientsPilot ProjectsPituitary GlandProspective StudiesResearchResearch PersonnelResourcesRiskRisk FactorsScoreSeverity of illnessShockSourceSystemTBI PatientsTraumaTraumatic Brain InjuryUnited States National Institutes of HealthVascular blood supplybiological adaptation to stresshypothalamic pituitary axismortality
项目摘要
This subproject is one of many research subprojects utilizing the
resources provided by a Center grant funded by NIH/NCRR. The subproject and
investigator (PI) may have received primary funding from another NIH source,
and thus could be represented in other CRISP entries. The institution listed is
for the Center, which is not necessarily the institution for the investigator.
Pituitary function is rarely considered in the care of pediatric patients with traumatic brain injury (TBI). TBI poses significant risk to pituitary function given the gland's location within the sella tucica and a vulnerable vascular supply. The mechanism by which damage may be sustained may result from direct mechanical trauma, or low cerebral blood flow states associated with shock or intracranial hypertension. Numerous case reports have noted abnormalities in the hypothalamic-pituitary axis (HPA) in children after craniocerebral injury whether it is acquired perinatally or from accidental or non-accidental trauma. There have been no prospective studies regarding the occurrence of acute post-traumatic hormonal deficits and associated risk factors. This is a pilot study examining the occurrence of unrecognized secondary or tertiary acute adrenal insufficiency (AAI) in children who are subjected to moderate and/or severe TBI of any etiology. To account for the hormonal stress response, the TBI children will be compared to a control group of children with extra-cranial injuries. A secondary evaluation will be made between accidental and non-accidental head trauma patients. For severity of illness comparison PRISM (Pediatric Risk of Mortality) scores are calculated for all children entered into the study. A scoring system will be employed to quantify risk factors, and an attempt to determine a relationship between the derived score and presence of AAI will be undertaken.
该副本是利用众多研究子项目之一
由NIH/NCRR资助的中心赠款提供的资源。子弹和
调查员(PI)可能已经从其他NIH来源获得了主要资金,
因此可以在其他清晰的条目中代表。列出的机构是
对于中心,这不一定是调查员的机构。
在儿科患者脑损伤(TBI)的儿科患者的护理中很少考虑垂体功能。鉴于腺体在塞拉·图西卡(Sella Tucica)和脆弱的血管供应中,TBI对垂体功能构成了重大风险。可能受到损害的机制可能是由直接的机械创伤引起的,或与休克或颅内高血压相关的低脑血流状态。大量病例报告指出,无论是围绕颅脑损伤还是因偶然或非事故创伤,颅骨损伤后儿童下丘脑垂体(HPA)异常。关于急性创伤后激素缺陷和相关危险因素的发生的前瞻性研究。这是一项试点研究,研究了未经识别的次级或高等急性肾上腺功能不全(AAI)的发生,这些儿童受到任何病因的中度和/或严重TBI的发生。为了考虑激素应力反应,将将TBI儿童与颅外伤害对照组进行比较。意外和非事故的头部外伤患者将进行次要评估。为了使疾病的严重程度比较棱镜(死亡率的小儿风险)分数均计算为研究的所有儿童。将采用评分系统来量化风险因素,并尝试确定派生得分与存在AAI之间的关系。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
CATHERINE S MAO其他文献
CATHERINE S MAO的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('CATHERINE S MAO', 18)}}的其他基金
EARLY HYPOPITUITARISM AFTER TRAUMATIC BRAIN INJURY IN CHILDREN
儿童脑外伤后早期垂体机能减退
- 批准号:
8174477 - 财政年份:2009
- 资助金额:
$ 1万 - 项目类别:
METABOLIC PHENOTYPE IN CHILDREN AND ADOLESCENTS AT-RISK FOR TYPE 2 DIABETES (DM)
有 2 型糖尿病 (DM) 风险的儿童和青少年的代谢表型
- 批准号:
8174487 - 财政年份:2009
- 资助金额:
$ 1万 - 项目类别:
PREVALENCE OF CORONARY ARTERY CALCIUM IN YOUNG ADULTS
年轻人冠状动脉钙化的患病率
- 批准号:
8174494 - 财政年份:2009
- 资助金额:
$ 1万 - 项目类别:
METABOLIC PHENOTYPE IN CHILDREN AND ADOLESCENTS AT-RISK FOR TYPE 2 DIABETES (DM)
有 2 型糖尿病 (DM) 风险的儿童和青少年的代谢表型
- 批准号:
7952246 - 财政年份:2008
- 资助金额:
$ 1万 - 项目类别:
PREVALENCE OF CORONARY ARTERY CALCIUM IN YOUNG ADULTS
年轻人冠状动脉钙化的患病率
- 批准号:
7952255 - 财政年份:2008
- 资助金额:
$ 1万 - 项目类别:
EARLY HYPOPITUITARISM AFTER TRAUMATIC BRAIN INJURY IN CHILDREN
儿童脑外伤后早期垂体机能减退
- 批准号:
7952228 - 财政年份:2008
- 资助金额:
$ 1万 - 项目类别:
METABOLIC PHENOTYPE IN CHILDREN AND ADOLESCENTS AT-RISK FOR TYPE 2 DIABETES (
有 2 型糖尿病风险的儿童和青少年的代谢表型(
- 批准号:
7606173 - 财政年份:2007
- 资助金额:
$ 1万 - 项目类别:
GLUTAMINE THERAPY IN PEDIATRIC DIABETIC KETOACIDOSIS
谷氨酰胺治疗小儿糖尿病酮症酸中毒
- 批准号:
7606158 - 财政年份:2007
- 资助金额:
$ 1万 - 项目类别:
METABOLIC PHENOTYPE IN CHILDREN AND ADOLESCENTS AT-RISK FOR TYPE 2 DIABETES (DM)
有 2 型糖尿病 (DM) 风险的儿童和青少年的代谢表型
- 批准号:
7606208 - 财政年份:2007
- 资助金额:
$ 1万 - 项目类别:
GLUTAMINE THERAPY IN PEDIATRIC DIABETIC KETOACIDOSIS
谷氨酰胺治疗小儿糖尿病酮症酸中毒
- 批准号:
7376055 - 财政年份:2005
- 资助金额:
$ 1万 - 项目类别:
相似国自然基金
用于急性出血控制的硅酸钙复合海绵的构建及其促凝血性能和机制研究
- 批准号:32301097
- 批准年份:2023
- 资助金额:30 万元
- 项目类别:青年科学基金项目
AF9通过ARRB2-MRGPRB2介导肠固有肥大细胞活化促进重症急性胰腺炎发生MOF的研究
- 批准号:82300739
- 批准年份:2023
- 资助金额:30 万元
- 项目类别:青年科学基金项目
代谢工程化MSC胞外囊泡靶向调控巨噬细胞线粒体动力学改善急性肾损伤的作用及机制研究
- 批准号:32371426
- 批准年份:2023
- 资助金额:50 万元
- 项目类别:面上项目
DUSP2介导自噬调控气管上皮细胞炎症在急性肺损伤中的机制研究
- 批准号:82360379
- 批准年份:2023
- 资助金额:32 万元
- 项目类别:地区科学基金项目
超声射频信号神经回路策略模型定量肌肉脂肪化评估慢加急性肝衰竭预后
- 批准号:82302221
- 批准年份:2023
- 资助金额:30 万元
- 项目类别:青年科学基金项目
相似海外基金
PREOPERATIVE BEXAROTENE TREATMENT FOR CUSHING'S DISEASE
库欣病术前贝沙罗汀治疗
- 批准号:
8167193 - 财政年份:2010
- 资助金额:
$ 1万 - 项目类别:
EARLY HYPOPITUITARISM AFTER TRAUMATIC BRAIN INJURY IN CHILDREN
儿童脑外伤后早期垂体机能减退
- 批准号:
8174477 - 财政年份:2009
- 资助金额:
$ 1万 - 项目类别:
EARLY HYPOPITUITARISM AFTER TRAUMATIC BRAIN INJURY IN CHILDREN
儿童脑外伤后早期垂体机能减退
- 批准号:
7952228 - 财政年份:2008
- 资助金额:
$ 1万 - 项目类别:
PATHOGENESIS AND THERAPY OF AUTOIMMUNE THYROID DISEASE
自身免疫性甲状腺疾病的发病机制和治疗
- 批准号:
7670775 - 财政年份:1980
- 资助金额:
$ 1万 - 项目类别:
PATHOGENESIS AND THERAPY OF AUTOIMMUNE THYROID DISEASE
自身免疫性甲状腺疾病的发病机制和治疗
- 批准号:
7234441 - 财政年份:1980
- 资助金额:
$ 1万 - 项目类别: