METABOLIC PHENOTYPE IN CHILDREN AND ADOLESCENTS AT-RISK FOR TYPE 2 DIABETES (

有 2 型糖尿病风险的儿童和青少年的代谢表型（

• 批准号: 7606173
• 负责人: CATHERINE S MAO
• 金额: $ 0.07万
• 依托单位: LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-02-01 至 2007-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7606173
• 关键词: Adolescent; Adult; Affect; Age; Blood Tests; Caucasians; Caucasoid Race; Child; Chronic Disease; Computer Retrieval of Information on Scientific Projects Database; Detection; Development; Diabetes Mellitus; Diet; Eating; Environment; Environmental Risk Factor; Event; Fatty acid glycerol esters; Food; Funding; Future; Grant; Infant; Institution; Insulin Resistance; Metabolic; Mexican Americans; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Onset of illness; Patients; Phenotype; Purpose; Research; Research Personnel; Resources; Risk; Siblings; Source; Time; United States National Institutes of Health; non-diabetic; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Mexican-Americans are more likely to get type 2 diabetes compared to Caucasians. Some people who eventually get diabetes have abnormal blood test or response to diet long before they develop diabetes. In fact, type 2 diabetes is seen at a younger age than before, especially in Mexican-American children. At the same time, an increase in obesity has been seen in these children. While it is not understood why type 2 diabetes has been occurring in younger children, it may be that environmental factors (such as the type and quantity of food eaten and the environment in which the child was raised) affect how type 2 diabetes is expressed. Intrauterine events or exposures may also impact later development of chronic disease including obesity, insulin resistance and diabetes mellitus. The purpose of this study is to determine if the type of irregularities seen in adults with type 2 diabetes are also found in children with diabetes and to determine if the body's response to high fat in the diet contributes to the development of diabetes. We also plan to determine if a "metabolic phenotype" of DM2 can be detected in infants and children which identify those at greatest risk for future DM2. The detection of such "metabolic phenotype" in non-diabetic siblings of children with type 2 diabetes may help to identify those at greatest risk for future development of type 2 diabetes. Early preventative strategies by modifying the environmental factors may delay the onset of disease in such a group of patients.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此，可以在其他清晰的条目中表示。列出的机构是 对于中心，这不一定是调查员的机构。 与高加索人相比，墨西哥裔美国人更有可能患2型糖尿病。一些最终患有糖尿病的人在患糖尿病之前很早就对饮食进行了异常的血液检查或对饮食的反应。实际上，比以前更年轻的年龄，尤其是在墨西哥裔美国人的儿童中，发现2型糖尿病。同时，在这些孩子中也发现了肥胖症的增加。虽然尚不清楚为什么年龄较小的孩子发生2型糖尿病，但可能是环境因素（例如，食用的食物类型和数量以及养育儿童的环境）会影响2型糖尿病的表达方式。宫内事件或暴露也可能影响以后的慢性疾病发展，包括肥胖，胰岛素抵抗和糖尿病。这项研究的目的是确定在糖尿病儿童中还发现了2型糖尿病的成年人中发现的不规则类型，并确定饮食中人体对高脂肪的反应是否有助于糖尿病的发展。我们还计划确定在婴儿和儿童中是否可以检测到DM2的“代谢表型”，这些儿童确定那些对未来DM2的风险最大的人。在患有2型糖尿病的儿童的非糖尿病兄弟姐妹中检测这种“代谢表型”可能有助于识别那些最大风险的2型糖尿病患者的风险。通过修改环境因素来提早预防策略可能会延迟此类患者的疾病发作。